{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:15:55Z","timestamp":1787508955102,"version":"build-2736575974"},"reference-count":48,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"A special medicine development grant of the Jilin Provincial Department of Science and Technology","award":["20191102031YY"],"award-info":[{"award-number":["20191102031YY"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technol Cancer Res Treat"],"published-print":{"date-parts":[[2021,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Cancer is associated with genetic variants of DNA repair genes that alter DNA repair capacity. The aim of this meta-analysis was to evaluate the relations between the rs13181 and rs1799793 XPD gene polymorphisms and risk for hepatocellular carcinoma (HCC) and gastric cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Relevant publications were systematically sought from Web of Science, Pubmed, and China Academic Journals Full-text Database. The selection of eligible studies was performed by 2 independent authors. A total of 32 case-control studies were included. Meta-analyses were undertaken in all study participants and each ethnic group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The risk of HCC was significantly increased with the XPD rs13181 G allele (P = 0.028, pooled odds ratio (OR) = 1.36, 95% confidence interval (CI) = 1.03-1.80) in all study participants. A subgroup analysis by ethnicity showed that the association was significant in Chinese (P = 0.009, pooled OR = 1.49, 95% CI = 1.11-2.02), but not in Caucasians (P = 0.619, pooled OR = 1.17, 95% CI = 0.64-2.13). Meta-analysis of the XPD rs1799793 polymorphism and HCC showed an association between its variant T allele and increased HCC risk in all study participants (P = 0.017, pooled OR = 1.23, 95% CI = 1.04-1.46, all Chinese). Our results showed no associations between the XPD rs13181 G allele and rs1799793 T allele and gastric cancer risk (rs13181: P = 0.298, pooled OR = 1.10, 95% CI = 0.92-1.31; rs1799793: P = 0.068, pooled OR = 1.31, 95% CI = 0.98-1.74).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This meta-analysis demonstrated that the XPD rs13181 G allele and rs1799793 T allele have significant associations with HCC and may be risk factors for HCC in the Chinese population. Current evidence indicated that they are not related to gastric cancer risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1533033821990046","type":"journal-article","created":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T04:58:37Z","timestamp":1612155517000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["XPD Polymorphisms and Risk of Hepatocellular Carcinoma and Gastric Cancer: A Meta-Analysis"],"prefix":"10.1177","volume":"20","author":[{"given":"Qiang","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Hepatology, The First Hospital of Jilin University, Changchun, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary Surgery, The First Hospital of Jilin University, Changchun, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijia","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary Surgery, The First Hospital of Jilin University, Changchun, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary Surgery, The First Hospital of Jilin University, Changchun, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary Surgery, The First Hospital of Jilin University, Changchun, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2933-0356","authenticated-orcid":false,"given":"Kai","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary Surgery, The First Hospital of Jilin University, Changchun, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,2,1]]},"reference":[{"key":"bibr1-1533033821990046","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12041050"},{"key":"bibr2-1533033821990046","doi-asserted-by":"publisher","DOI":"10.1101\/gad.859501"},{"key":"bibr3-1533033821990046","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2009.08.002"},{"key":"bibr4-1533033821990046","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11101450"},{"key":"bibr5-1533033821990046","doi-asserted-by":"publisher","DOI":"10.1080\/14737159.2019.1660645"},{"key":"bibr6-1533033821990046","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1193"},{"key":"bibr7-1533033821990046","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"bibr8-1533033821990046","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh075"},{"key":"bibr9-1533033821990046","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyi191"},{"key":"bibr10-1533033821990046","unstructured":"Xie WM. 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