{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:26:44Z","timestamp":1793320004874,"version":"4.5.0"},"reference-count":51,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"the Second Batch of Scientific Research Projects of Dengfeng Plan","award":["DFJH201913"],"award-info":[{"award-number":["DFJH201913"]}]},{"name":"the Research Fund of CSCO-Hansoh Oncology","award":["Y-HS2019\/2-050"],"award-info":[{"award-number":["Y-HS2019\/2-050"]}]},{"name":"the Medical Scientific Research Foundation of Guangdong Province","award":["A2020019"],"award-info":[{"award-number":["A2020019"]}]},{"name":"the Science and Technology Plan of Guangzhou","award":["202102080230"],"award-info":[{"award-number":["202102080230"]}]},{"name":"the Research Fund of CSCO-Roche Oncology","award":["Y-2019Roche-190"],"award-info":[{"award-number":["Y-2019Roche-190"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technol Cancer Res Treat"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Background: Anterior resection is a common surgical approach used in rectal cancer surgery; however, this procedure is known to cause bowel injury and dysfunction. Neoadjuvant therapy is widely used in patients with locally advanced rectal cancer. In this study, we determined the effect of preoperative radiotherapy on long-term bowel function in patients who underwent anterior resection for treatment of rectal cancer. Methods: We performed a comprehensive literature search of the PubMed, Embase, Web of Science, and the Cochrane Library databases. A random-effects model was used in the meta-analysis by the Review Manager software, version 5.3. Results: This systematic review and meta-analysis included 12 studies, which used low anterior resection syndrome score with a total of 2349 patients. Based on them, we concluded that low anterior resection syndrome was significantly more common in the preoperative radiotherapy group (odds ratio 3.59, 95% confidence interval 2.68-4.81, P\u2009&lt;\u2009.00001) and that major low anterior resection syndrome also occurred significantly more frequently in the preoperative radiotherapy group (odds ratio 3.28, 95% confidence interval 2.05-5.26, P\u2009&lt;\u2009.00001). Subgroup analyses of long-course radiation, total mesorectal excision, and non-metastatic tumors were performed, and the results met the conclusions of the primary outcomes. Conclusions: Preoperative radiotherapy negatively affects long-term bowel function in patients who undergo anterior resection for rectal cancer.<\/jats:p>","DOI":"10.1177\/15330338221105156","type":"journal-article","created":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T12:49:42Z","timestamp":1655902182000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Effects of Preoperative Radiotherapy on Long-Term Bowel Function in Patients With Rectal Cancer Treated With Anterior Resection: A Systematic Review and Meta-analysis"],"prefix":"10.1177","volume":"21","author":[{"given":"Zongyu","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery, Department of General Surgery, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People\u2019s Republic of China"},{"name":"Guangdong Provincial People\u2019s Hospital Ganzhou Hospital (Ganzhou Municipal Hospital), Ganzhou, People\u2019s Republic of China"},{"name":"Shantou University Medical College, Shantou, Guangdong Province, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaojun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Department of General Surgery, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People\u2019s Republic of China"},{"name":"Guangdong Provincial People\u2019s Hospital Ganzhou Hospital (Ganzhou Municipal Hospital), Ganzhou, People\u2019s Republic of China"},{"name":"School of Medicine, South China University of Technology, Guangzhou, Guangdong, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deqing","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Department of General Surgery, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengzhi","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Department of General Surgery, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People\u2019s Republic of China"},{"name":"Guangdong Provincial People\u2019s Hospital Ganzhou Hospital (Ganzhou Municipal Hospital), Ganzhou, People\u2019s Republic of China"},{"name":"School of Medicine, South China University of Technology, Guangzhou, Guangdong, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Department of General Surgery, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People\u2019s Republic of China"},{"name":"Guangdong Provincial People\u2019s Hospital Ganzhou Hospital (Ganzhou Municipal Hospital), Ganzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixian","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Department of General Surgery, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Department of General Surgery, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People\u2019s Republic of China"},{"name":"Shantou University Medical College, Shantou, Guangdong Province, People\u2019s Republic of China"},{"name":"School of Medicine, South China University of Technology, Guangzhou, Guangdong, People\u2019s Republic of China"},{"name":"The Second School of Clinical Medicine, Southern Medical University, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyu","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Department of General Surgery, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People\u2019s Republic of China"},{"name":"Shantou University Medical College, Shantou, Guangdong Province, People\u2019s Republic of China"},{"name":"The Second School of Clinical Medicine, Southern Medical University, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0570-7585","authenticated-orcid":false,"given":"Xueqing","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Department of General Surgery, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People\u2019s Republic of China"},{"name":"Guangdong Provincial People\u2019s Hospital Ganzhou Hospital (Ganzhou Municipal Hospital), Ganzhou, People\u2019s Republic of China"},{"name":"Shantou University Medical College, Shantou, Guangdong Province, People\u2019s Republic of China"},{"name":"School of Medicine, South China University of Technology, Guangzhou, Guangdong, People\u2019s Republic of China"},{"name":"The Second School of Clinical Medicine, Southern Medical University, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,6,22]]},"reference":[{"key":"bibr1-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-021-04008-3"},{"key":"bibr2-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1007\/BF02050593"},{"key":"bibr3-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2018.06.031"},{"key":"bibr4-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2354.2005.00647.x"},{"key":"bibr5-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1007\/BF02049473"},{"key":"bibr6-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2006.00992.x"},{"key":"bibr7-15330338221105156","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.15438"},{"key":"bibr8-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1111\/ans.15552"},{"key":"bibr9-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-021-02436-5"},{"key":"bibr10-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-021-06326-2"},{"key":"bibr11-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1586\/14737140.2014.911090"},{"key":"bibr12-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2010.02.007"},{"key":"bibr13-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1111\/jebm.12427"},{"key":"bibr14-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-019-04901-2"},{"key":"bibr15-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2015.07.003"},{"issue":"9","key":"bibr16-15330338221105156","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1111\/codi.12244","volume":"15","author":"Bregendahl S","year":"2013","journal-title":"Colorectal Dis"},{"key":"bibr17-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1111\/ans.14749"},{"key":"bibr18-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9223"},{"key":"bibr19-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000801"},{"key":"bibr20-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-016-2659-6"},{"key":"bibr21-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-018-07096-8"},{"key":"bibr22-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(20)30832-X"},{"key":"bibr23-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1080\/08941939.2020.1864684"},{"key":"bibr24-15330338221105156","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10040768"},{"key":"bibr25-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1111\/codi.15095"},{"key":"bibr26-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1159\/000490899"},{"key":"bibr27-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3182138e79"},{"key":"bibr28-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1016\/j.clcc.2014.12.007"},{"key":"bibr29-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000001228"},{"key":"bibr30-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1136\/jim-2016-000229"},{"key":"bibr31-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-016-4268-1"},{"key":"bibr32-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2018.02.009"},{"key":"bibr33-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1007\/BF02050307"},{"key":"bibr34-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31824f1c21"},{"key":"bibr35-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2012.02.002"},{"key":"bibr36-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-015-0479-4"},{"key":"bibr37-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2015.03.038"},{"key":"bibr38-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2006.01002.x"},{"key":"bibr39-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.14.779"},{"key":"bibr40-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-020-08974-w"},{"key":"bibr41-15330338221105156","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18030573"},{"key":"bibr42-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/921435"},{"key":"bibr43-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2019.10.010"},{"issue":"4","key":"bibr44-15330338221105156","first-page":"688","volume":"67","author":"Battersby NJ","year":"2018","journal-title":"Gut"},{"key":"bibr45-15330338221105156","doi-asserted-by":"publisher","DOI":"10.23922\/jarc.2021-033"},{"key":"bibr46-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1093\/bjs\/znab388"},{"key":"bibr47-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-018-4003-7"},{"key":"bibr48-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1016\/j.asjsur.2021.02.010"},{"key":"bibr49-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1016\/j.clcc.2019.07.001"},{"key":"bibr50-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2020.01.005"},{"key":"bibr51-15330338221105156","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000001646"}],"container-title":["Technology in Cancer Research &amp; Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15330338221105156","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15330338221105156","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15330338221105156","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T06:10:45Z","timestamp":1777702245000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15330338221105156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":51,"alternative-id":["10.1177\/15330338221105156"],"URL":"https:\/\/doi.org\/10.1177\/15330338221105156","relation":{},"ISSN":["1533-0346","1533-0338"],"issn-type":[{"value":"1533-0346","type":"print"},{"value":"1533-0338","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"article-number":"15330338221105156"}}