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Almost all patients with multiple myeloma eventually have a relapse. Many studies have demonstrated the importance of the various genomic mutations that characterize multiple myeloma as a complex heterogeneous disease. In recent years, next-generation sequencing has been used to identify the genomic mutation landscape and clonal heterogeneity of multiple myeloma. This is the first study, a prospective observational study, to identify somatic mutations in plasma cell disorders in the Thai population using targeted next-generation sequencing. Twenty-seven patients with plasma cell disorders were enrolled comprising 17 cases of newly diagnosed multiple myeloma, 5 cases of relapsed\/refractory multiple myeloma, and 5 cases of other plasma cell disorders. The pathogenic mutations were found in 17 of 27 patients. Seventy percent of those who had a mutation (12\/17 patients) habored a single mutation, whereas the others had more than one mutation. Fifteen pathogenic mutation genes were identified: ATM, BRAF, CYLD, DIS3, DNMT3A, FBXW7, FLT3, GNA13, IRF4, KMT2A, NRAS, SAMHD1, TENT5C, TP53, and TRAF3. Most have previously been reported to be involved in the RAS\/MAPK pathway, the nuclear factor kappa B pathway, the DNA-repair pathway, the CRBN pathway, tumor suppressor gene mutation, or an epigenetic mutation. However, the current study also identified mutations that had not been reported to be related to myeloma: GNA13 and FBXW7. Therefore, a deep understanding of molecular genomics would inevitably improve the clinical management of plasma cell disorder patients, and the increased knowledge would ultimately result in better outcomes for the patients.<\/jats:p>","DOI":"10.1177\/15330338221111228","type":"journal-article","created":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T02:39:40Z","timestamp":1656556780000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparison of Clinical Characteristics and Genetic Aberrations of Plasma Cell Disorders in Thailand Population"],"prefix":"10.1177","volume":"21","author":[{"given":"Chutirat","family":"Jirabanditsakul","sequence":"first","affiliation":[{"name":"Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand"},{"name":"Department of Clinical Microscopy, Faculty of Medical Technology, Mahidol University, Nakhon Pathom, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumana","family":"Dakeng","sequence":"additional","affiliation":[{"name":"Department of Clinical Microscopy, Faculty of Medical Technology, Mahidol University, Nakhon Pathom, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chutima","family":"Kunacheewa","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaowalak","family":"U-pratya","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1262-2005","authenticated-orcid":false,"given":"Weerapat","family":"Owattanapanich","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,6,29]]},"reference":[{"key":"bibr1-15330338221111228","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204641"},{"key":"bibr2-15330338221111228","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-11-568881"},{"key":"bibr3-15330338221111228","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-011110-130249"},{"key":"bibr4-15330338221111228","doi-asserted-by":"publisher","DOI":"10.1002\/9780470015902.a0004030.pub2"},{"key":"bibr5-15330338221111228","doi-asserted-by":"publisher","DOI":"10.5772\/55855"},{"key":"bibr6-15330338221111228","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.46"},{"key":"bibr7-15330338221111228","doi-asserted-by":"publisher","DOI":"10.1016\/j.disamonth.2014.08.002"},{"key":"bibr8-15330338221111228","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60493-1"},{"key":"bibr9-15330338221111228","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70404-2"},{"key":"bibr10-15330338221111228","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1011442"},{"key":"bibr11-15330338221111228","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2005.01.008"},{"key":"bibr12-15330338221111228","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-0866"},{"key":"bibr13-15330338221111228","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2015.1.272"},{"key":"bibr14-15330338221111228","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-631200"},{"key":"bibr15-15330338221111228","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-018-0018-y"},{"key":"bibr16-15330338221111228","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-112017-091045"},{"key":"bibr17-15330338221111228","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19123924"},{"key":"bibr18-15330338221111228","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-0625"},{"key":"bibr19-15330338221111228","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2017.1.508"},{"key":"bibr20-15330338221111228","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0362-z"},{"key":"bibr21-15330338221111228","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12805"},{"key":"bibr22-15330338221111228","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-10-567370"},{"key":"bibr23-15330338221111228","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2016.02.025"},{"key":"bibr24-15330338221111228","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3997"},{"key":"bibr25-15330338221111228","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2013.814637"},{"key":"bibr26-15330338221111228","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2016.122"},{"key":"bibr27-15330338221111228","unstructured":"\u00a9Agilent Technologies, Inc. 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