{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T01:27:25Z","timestamp":1789522045048,"version":"build-2803163510"},"reference-count":22,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073335"],"award-info":[{"award-number":["82073335"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Key Specialty program of Natural Science Foundation of Beijing Municipality","award":["Z20008"],"award-info":[{"award-number":["Z20008"]}]},{"name":"the Special Fund of National Clinical Key Specialty Construction Program of China","award":["2021"],"award-info":[{"award-number":["2021"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technol Cancer Res Treat"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the clinical outcomes of volumetric modulated arc therapy (VMAT) followed by brachytherapy (BT), combined with chemotherapy, and local hyperthermia (HT) on locally advanced cervical cancer (LACC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In total, 40 patients with FIGO stage IB1-IVB cervical cancer from January 2016 to December 2018 were selectively enrolled in this study. All patients were treated with VMAT (50.4\u2005Gy\/1.8\u2005Gy\/28\u2005f) concurrent with cisplatin-based chemotherapy (40\u2005mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , q1w, 6 cycles) and local HT (40.5-41\u00b0C for 60\u2005min, BIW). BT (30-36 y\/5-6 f, 2 f\/w) was conducted after VMAT. Objective response rate (ORR), local control (LC) time, LC rate, progression-free survival (PFS) rate, cancer-specific survival (CSS) rate, overall survival (OS), median time to tumor progression and treatment-related toxicity were evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median follow-up time was 31 months (8-48). The ORR was 100% at 3 months after treatment and 92.1% at 6 months, respectively. The 1-year, 2-year, and 3-year LC rates were 87.4%, 81.9%, and 70.9%, respectively. The average LC time was 31.50\u2009\u00b1\u20091.89 months (95% CI 27.79-35.21). The 1-year, 2-year, and 3-year PFS rates were 75.85%, 61.2%, and 51.3%, respectively, while the median PFS was 27.07 months. The 1-year, 2-year, and 3-year OS rates were 95%, 84%, and 79.6%, respectively. In total, 12(30%) patients had grade 3\/4 bone marrow suppression. One patient had grade 4 leukopenia. In total, 17 patients had grade 1\/2 bone marrow suppression. Two patients had grade 3 nausea and grade 3 vomiting reaction, respectively. No grade 3\/4 proctitis and bladder reaction were observed. In the late period of treatment, 1 patient had a rectal hemorrhage. In total, 13 patients had vaginal stenosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>VMAT concurrent with chemotherapy, BT, and local HT had a favorable short-term efficacy and acceptable toxicity on cervical cancer, which was an alternative option for LACC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15330338231185013","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T03:54:52Z","timestamp":1687751692000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["The Efficacy of Volumetric Modulated Arc Therapy Combined With Chemotherapy, Brachytherapy, and Local Hyperthermia on Patients with Locally Advanced Cervical Cancer: A Retrospective Study"],"prefix":"10.1177","volume":"22","author":[{"given":"Ping","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Peking University 3rd Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhua","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Peking University 3rd Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Peking University 3rd Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Peking University 3rd Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijuan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Peking University 3rd Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Peking University 3rd Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2264-6745","authenticated-orcid":false,"given":"Junjie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Peking University 3rd Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,6,26]]},"reference":[{"key":"bibr1-15330338231185013","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"bibr2-15330338231185013","doi-asserted-by":"publisher","DOI":"10.1118\/1.2818738"},{"key":"bibr3-15330338231185013","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199904153401502"},{"key":"bibr4-15330338231185013","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2020.03.006"},{"key":"bibr5-15330338231185013","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.8.1606"},{"key":"bibr6-15330338231185013","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199904153401501"},{"key":"bibr7-15330338231185013","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199904153401503"},{"key":"bibr8-15330338231185013","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.5.1339"},{"key":"bibr9-15330338231185013","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2021-002473"},{"key":"bibr10-15330338231185013","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.07.2348"},{"key":"bibr11-15330338231185013","doi-asserted-by":"publisher","DOI":"10.1080\/02656736.2016.1213430"},{"key":"bibr12-15330338231185013","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"bibr13-15330338231185013","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.4368"},{"key":"bibr14-15330338231185013","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.06.052"},{"key":"bibr15-15330338231185013","doi-asserted-by":"publisher","DOI":"10.3109\/02656736.2012.674622"},{"key":"bibr16-15330338231185013","doi-asserted-by":"publisher","DOI":"10.3109\/02656736.2012.673047"},{"key":"bibr17-15330338231185013","doi-asserted-by":"publisher","DOI":"10.3109\/02656736.2012.732251"},{"key":"bibr18-15330338231185013","doi-asserted-by":"publisher","DOI":"10.1080\/02656730500271668"},{"key":"bibr19-15330338231185013","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02059-6"},{"issue":"3","key":"bibr20-15330338231185013","first-page":"Cd006377","volume":"2010","author":"Lutgens L","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr21-15330338231185013","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.12.020"},{"key":"bibr22-15330338231185013","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27652"}],"container-title":["Technology in Cancer Research &amp; 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