{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:32:24Z","timestamp":1777941144568,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Department of Research and Development, Division of Emergencies and Critical Care, Oslo University Hospital","award":["PhD grant"],"award-info":[{"award-number":["PhD grant"]}]},{"name":"Department of Gastroenterological Surgery, Oslo University Hospital","award":["Grant"],"award-info":[{"award-number":["Grant"]}]},{"name":"Fondsstiftelsen, Oslo University Hospital","award":["Grant"],"award-info":[{"award-number":["Grant"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technol Cancer Res Treat"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>\n                    Despite extensive treatment with surgery and chemotherapy many patients with peritoneal metastases from colorectal cancer experience intraperitoneal disease relapse. The \u03b1-emitting\n                    <jats:sup>224<\/jats:sup>\n                    radium-labelled microparticle radionuclide therapeutic Radspherin\u00ae is being explored as a novel treatment option for these patients. Radspherin\u00ae is specially designed to give local radiation to the surface of the peritoneal cavity and potentially kill remaining attached micrometastases as well as free-floating cancer cells, thus preventing future relapse. The effect of Radspherin\u00ae on the immune system is not known. Systemic and local inflammatory responses were analyzed in plasma, intraperitoneal fluid and urine collected prospectively as part of a phase 1 dose-escalation study of intraperitoneal instillation of the \u03b1-emitting therapeutic radiopharmaceutical Radspherin\u00ae, at baseline and the first 7 postoperative days from nine patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. All patients additionally received intraperitoneal instillation of Radspherin\u00ae on postoperative day 2. Complement activation products C3bc and the terminal complement complex were analyzed using enzyme-linked immunosorbent assay. Cytokines ( n\u2009=\u200927), including interleukins, chemokines, interferons and growth factors, were analyzed using multiplex technique. The time course and magnitude of the postoperative cytokine response after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy displayed a modest systemic response in plasma, in contrast to a substantial local intraperitoneal response. After administration of Radspherin\u00ae, a significant increase ( P\u2009&lt;\u20090.05) in TNF and MIP-1\u03b2 was observed in both plasma and peritoneal fluid, whereas IL-9 increased only in plasma and IFN\u03b3 and IL1-RA only in peritoneal fluid. Only minor changes were seen for the majority of the inflammatory markers after Radspherin\u00ae administration. Our study showed a predominately local rather than systemic inflammatory response to cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Radspherin\u00ae had overall modest impact on the inflammation.\n                  <\/jats:p>","DOI":"10.1177\/15330338231192902","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T03:14:37Z","timestamp":1691982877000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Intraperitoneal\n                    <sup>224<\/sup>\n                    Radium-Labelled Microparticles on Compartmentalized Inflammation After Cytoreductive Surgery and Hypertherm Intraperitoneal Chemotherapy"],"prefix":"10.1177","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6264-9436","authenticated-orcid":false,"given":"Ebbe Billmann","family":"Thorgersen","sequence":"first","affiliation":[{"name":"Department of Gastroenterological Surgery, Oslo University Hospital, The Radium Hospital, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9781-5315","authenticated-orcid":false,"given":"J\u00f8rund","family":"Asvall","sequence":"additional","affiliation":[{"name":"Department of Research and Development, Division of Emergencies and Critical Care, Oslo University Hospital, Oslo, Norway"},{"name":"Institute of Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla","family":"Schjalm","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Oslo, Oslo, Norway"},{"name":"Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin Ekholt","family":"McAdam","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Oslo, Oslo, Norway"},{"name":"Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d8yvind Sverre","family":"Bruland","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Oslo, Oslo, Norway"},{"name":"Department of Oncology, Oslo University Hospital, The Radium Hospital, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stein Gunnar","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Oslo University Hospital, The Radium Hospital, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom Eirik","family":"Mollnes","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Oslo, Oslo, Norway"},{"name":"Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway"},{"name":"Research Laboratory, Nordland Hospital, Bod\u00f8, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,8,14]]},"reference":[{"key":"bibr1-15330338231192902","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.9285"},{"key":"bibr2-15330338231192902","doi-asserted-by":"publisher","DOI":"10.1016\/S1055-3207(03)00048-6"},{"key":"bibr3-15330338231192902","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24290"},{"key":"bibr4-15330338231192902","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1070362"},{"key":"bibr5-15330338231192902","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1058914"},{"key":"bibr6-15330338231192902","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-021-10022-0"},{"key":"bibr7-15330338231192902","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9635-x"},{"key":"bibr8-15330338231192902","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181afde41"},{"key":"bibr9-15330338231192902","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1988.tb02354.x"},{"key":"bibr10-15330338231192902","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1985.tb01871.x"},{"key":"bibr11-15330338231192902","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2013.05.221"},{"key":"bibr12-15330338231192902","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.9.6346"},{"key":"bibr13-15330338231192902","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0903613106"},{"key":"bibr14-15330338231192902","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2008.05.017"},{"key":"bibr15-15330338231192902","doi-asserted-by":"publisher","DOI":"10.1038\/nature07201"},{"key":"bibr16-15330338231192902","doi-asserted-by":"publisher","DOI":"10.1126\/science.abi5200"},{"key":"bibr17-15330338231192902","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxaa078"},{"key":"bibr18-15330338231192902","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2005.01.006"},{"key":"bibr19-15330338231192902","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-6516-2"},{"key":"bibr20-15330338231192902","doi-asserted-by":"publisher","DOI":"10.2174\/13816128113199990449"},{"key":"bibr21-15330338231192902","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2015.06.017"},{"key":"bibr22-15330338231192902","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-017-6112-z"},{"key":"bibr23-15330338231192902","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.807539"},{"key":"bibr24-15330338231192902","doi-asserted-by":"publisher","DOI":"10.1080\/02656736.2017.1293304"},{"key":"bibr25-15330338231192902","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2018-000099"},{"key":"bibr26-15330338231192902","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12332"},{"key":"bibr27-15330338231192902","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2004.02.005"},{"key":"bibr28-15330338231192902","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.09.011"},{"key":"bibr29-15330338231192902","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.31750"},{"key":"bibr30-15330338231192902","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"bibr31-15330338231192902","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2015.1069938"},{"key":"bibr32-15330338231192902","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2011.06.012"},{"key":"bibr33-15330338231192902","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.995325"}],"container-title":["Technology 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