{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:32:30Z","timestamp":1777941150863,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technol Cancer Res Treat"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>\n                    Introduction: Recurrence after stage III lung cancer treatment usually appears with a poor prognosis, and salvage therapy for these patients is challenging, with limited data for reirradiation. Materials and Methods: Fifteen patients with recurrent stage III lung cancer treated with stereotactic body radiotherapy (SABR) between October 2013 and December 2017 were retrospectively evaluated for local control as a first endpoint; overall survival, disease-free survival, and treatment-related toxicity were secondary endpoints. Results: The median age was 68 (IQR: 50-71) years, and the median tumor size was 3.3\u2005cm (IQR: 3.0-4.5). The radiation field was all within the previous radiation (previous 80%-90% isodose line), and the median dose was 66\u2005Gy\/(2\u2005Gy\u2009\u00d7\u200933 standard fractionation) . For SABR, the median biologically effective dose at an \u03b1\/\u03b2 ratio of 10 (BED\n                    <jats:sub>10<\/jats:sub>\n                    ) was 60.0\u2005Gy (IQR: 39.38-85.0) and given in 3 to 5 fractions. Three patients experienced grade 3 or 4 toxicity but none experienced grade 5. The median follow-up period was 14 (IQR: 10-23) months. The local control rate was found as 86.7% in the first year, 80% in the second year, and 80% in the third year. The median disease-free survival was 8 (IQR: 6-20) months and the median overall survival was 14 (IQR: 10-23) months. The rate of overall survival was 66.6% for the first year and 33.3% for the second and third years. The disease-free survival rate was 46.6% for the first year and 40% for the second and third years. Nine patients who received doses of BED\n                    <jats:sub>10<\/jats:sub>\n                    \u2009\u2265\u200950\u2005Gy developed no local recurrence ( P\u2009\u2009=\u2009\u2009.044). Discussion: In local local\u2013regional recurrence of lung cancer, radiosurgery as reirradiation can be used at doses of BED\n                    <jats:sub>10<\/jats:sub>\n                    \u2009\u2265\u200950\u2005Gy and above to provide local control for radical or palliative purposes. SABR is an important and relatively safe treatment option in such recurrences.\n                  <\/jats:p>","DOI":"10.1177\/15330338231208616","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T06:33:21Z","timestamp":1718087601000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Stereotactic Body Radiotherapy Reirradiation Is Safe in Patients With Lung Cancer With In-Field Enlarged Tumor Recurrence"],"prefix":"10.1177","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4087-4760","authenticated-orcid":false,"given":"Tanju","family":"Berber","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Okmeydani Training and Research Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berna Akku\u015f","family":"Y\u0131ld\u0131r\u0131m","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Okmeydani Training and Research Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6zge","family":"Kandemir G\u00fcrsel","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Okmeydani Training and Research Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,6,11]]},"reference":[{"key":"bibr1-15330338231208616","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000749"},{"key":"bibr2-15330338231208616","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx222"},{"key":"bibr3-15330338231208616","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djr325"},{"key":"bibr4-15330338231208616","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/87.3.198"},{"key":"bibr5-15330338231208616","doi-asserted-by":"publisher","DOI":"10.1097\/01243894-200611000-00021"},{"key":"bibr6-15330338231208616","doi-asserted-by":"publisher","DOI":"10.1007\/s13566-014-0175-2"},{"key":"bibr7-15330338231208616","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.09.070"},{"key":"bibr8-15330338231208616","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-8-99"},{"key":"bibr9-15330338231208616","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-5542-3"},{"key":"bibr10-15330338231208616","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-005-0501-1"},{"key":"bibr11-15330338231208616","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(01)02644-X"},{"key":"bibr12-15330338231208616","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2003.09.087"},{"key":"bibr13-15330338231208616","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.01.069"},{"key":"bibr14-15330338231208616","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.7469"},{"key":"bibr15-15330338231208616","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2020.11.009"},{"key":"bibr16-15330338231208616","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2012.02.020"},{"key":"bibr17-15330338231208616","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S360766"},{"key":"bibr18-15330338231208616","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2009.05.039"},{"key":"bibr19-15330338231208616","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2016.03.081"},{"key":"bibr20-15330338231208616","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21388"},{"key":"bibr21-15330338231208616","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.3.205"},{"key":"bibr22-15330338231208616","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-016-3297-9"},{"key":"bibr23-15330338231208616","doi-asserted-by":"publisher","DOI":"10.1118\/1.3438081"},{"key":"bibr24-15330338231208616","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2014.07.030"},{"key":"bibr25-15330338231208616","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.01162"},{"key":"bibr26-15330338231208616","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70345-6"},{"key":"bibr27-15330338231208616","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(03)00768-5"},{"key":"bibr28-15330338231208616","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0000000000000709"},{"key":"bibr29-15330338231208616","first-page":"643","volume":"20","author":"Berber T","year":"2022","journal-title":"Int J Radiat Res"},{"key":"bibr30-15330338231208616","doi-asserted-by":"publisher","DOI":"10.1016\/j.canrad.2021.02.003"},{"key":"bibr31-15330338231208616","doi-asserted-by":"publisher","DOI":"10.1016\/j.adro.2021.100653"},{"key":"bibr32-15330338231208616","doi-asserted-by":"publisher","DOI":"10.3857\/roj.2015.33.4.265"},{"key":"bibr33-15330338231208616","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-83210-3"},{"key":"bibr34-15330338231208616","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol28030170"}],"container-title":["Technology in Cancer Research &amp; 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