{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:01:01Z","timestamp":1792800061765,"version":"4.5.0"},"reference-count":28,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"the Medical Scientific Research Project of Jiangsu Provincial Commission Health and Family Planning","award":["H2017048"],"award-info":[{"award-number":["H2017048"]}],"id":[{"id":"https:\/\/ror.org\/01rr3tg72","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technol Cancer Res Treat"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Objective: Finding biomarkers related to non-small cell lung cancer (NSCLC) is helpful for the diagnosis and precise treatment of lung cancer. The relationship between serum tumor M2-pyruvate kinase (TuM2-PK), carcinoembryonic antigen (CEA), and cytokeratin 19 fragment (CYFRA21-1) and NSCLC was analyzed. Methods: The serum levels of TuM2-PK, CEA, and CYFRA21-1 in 184 patients with the NSCLC group, 60 patients with the benign lung disease (BLD) group, and 90 healthy controls (HC) group were detected. The levels of TuM2-PK were measured by using an enzyme-linked immunosorbent assay. The detection methods of CEA and CYFRA21-1 were electrochemiluminescence. The receiver operating characteristic (ROC) curve was drawn to evaluate the diagnostic value of TuM2-PK, CEA, and CYFRA21-1 on NSCLC. The Kaplan\u2013Meier survival curve was drawn to evaluate the survival status in NSCLC patients with different serum levels of TuM2-PK, CEA, and CYFRA21-1. Results: Serum levels of TuM2-PK, CEA, and CYFRA21-1 in the NSCLC group were significantly higher than those in the BLD group and the HC group ( P\u2009&lt;\u2009.01). Serum levels of TuM2-PK, CEA, and CYFRA21-1 in NSCLC patients were associated with the tumor lymph node metastasis stage ( P\u2009&lt;\u2009.05), lymph node metastasis ( P\u2009&lt;\u2009.05), and distant metastasis ( P\u2009&lt;\u2009.05). The ROC curve showed that the area under the curve of serum levels of TuM2-PK, CEA, and CYFRA21-1 was 0.814, 0.638, and 0.719, respectively, and that the combination of the above 3 was 0.918. The Kaplan\u2013Meier survival curve showed that the 1-, 3- and 5-year survival rate in NSCLC patients with positive TuM2-PK, CEA, and CYFRA21-1 was significantly lower than that in NSCLC patients with negative TuM2-PK, CEA, and CYFRA21-1, respectively ( P\u2009&lt;\u2009.05). Conclusions: Serum TuM2-PK, CEA, and CYFRA21-1 levels have high clinical values in the diagnosis of NSCLC, and can effectively judge the prognosis of patients.<\/jats:p>","DOI":"10.1177\/15330338241265983","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T18:08:49Z","timestamp":1721758129000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["The Diagnostic and Prognostic Value of the Combination of Tumor M2-Pyruvate Kinase, Carcinoembryonic Antigen, and Cytokeratin 19 Fragment in Non-Small Cell Lung Cancer"],"prefix":"10.1177","volume":"23","author":[{"given":"Li","family":"Li","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, Affiliated to Nanjing Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu, China"},{"name":"Department of Respiratory Medicine, Affiliated to Nanjing Chest Hospital, Southeast University, Nanjing, Jiangsu, 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Medical Imaging Department II, Affiliated to Nanjing Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3224-4195","authenticated-orcid":false,"given":"Chunhua","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Affiliated to Nanjing Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu, China"},{"name":"Department of Respiratory Medicine, Affiliated to Nanjing Chest Hospital, Southeast University, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,7,23]]},"reference":[{"key":"bibr1-15330338241265983","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21654"},{"key":"bibr2-15330338241265983","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2010.01892.x"},{"key":"bibr3-15330338241265983","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15518"},{"key":"bibr4-15330338241265983","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"bibr5-15330338241265983","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2018.05.008"},{"key":"bibr6-15330338241265983","doi-asserted-by":"publisher","DOI":"10.1002\/pro.505"},{"key":"bibr7-15330338241265983","doi-asserted-by":"publisher","DOI":"10.4318\/tjg.2013.0607"},{"key":"bibr8-15330338241265983","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-015-0490-2"},{"key":"bibr9-15330338241265983","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-018-1360-3"},{"key":"bibr10-15330338241265983","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2011.11.012"},{"key":"bibr11-15330338241265983","doi-asserted-by":"publisher","DOI":"10.31557\/APJCP.2019.20.10.2979"},{"issue":"5","key":"bibr12-15330338241265983","first-page":"1417","volume":"18","author":"Akinci 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