{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:33:20Z","timestamp":1777941200708,"version":"3.51.4"},"reference-count":51,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013058","name":"Jiangsu Provincial Key Research and Development Program","doi-asserted-by":"publisher","award":["BE2017696"],"award-info":[{"award-number":["BE2017696"]}],"id":[{"id":"10.13039\/501100013058","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation, China","doi-asserted-by":"crossref","award":["81871234"],"award-info":[{"award-number":["81871234"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation, China","doi-asserted-by":"crossref","award":["82172763"],"award-info":[{"award-number":["82172763"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation, China","doi-asserted-by":"crossref","award":["82272824"],"award-info":[{"award-number":["82272824"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technol Cancer Res Treat"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Background: To evaluate the efficacy and safety of allogenic CD8\u2009+\u2009natural killer T (CD8+ NKT) immunotherapy combined with gefitinib in the treatment of advanced or metastatic EGFR mutant non-small cell lung cancer (NSCLC). Methods: This study is prospective. The NSCLC patients with exon 19 (Ex19del) or exon 21 L858R point mutations, and response to gefitinib treatment were enrolled into the trial to be randomly assigned into the gefitinib arm and the gefitinib\/NKT arm. Allogenic CD8+ NKT cells were cultured in vitro and adaptive transferred into the patients via vein in the gefitinib\/NKT arm. The primary endpoint was progression-free survival (PFS). Secondary endpoint analysis included time to disease progression (TTP), overall survival (OS), levels of serum tumour markers for carcinoembryonic antigen (CEA) and alanine aminotransferase (ALT) in the blood, the response rate and safety. From July 2017 to June 2021, 19 patients were randomly assigned to the gefitinib arm (n\u2009=\u20098) and the gefitinib\/NKT arm (n\u2009=\u200911). Results: The estimated median survival PFS in the gefitinib\/NKT arm was significantly longer than that of the gefitinib arm (12 months vs 7 months). Similar results were also observed for the median TTP. Moreover, the gefitinib\/NKT arm had better CEA control than the gefitinib arm. Clinical grade 3 adverse reactions occurred in 64% and 39% of patients in the gefitinib\/NKT arm and the gefitinib arm, respectively. The most common grade 3 adverse events in the gefitinib\/NKT arm included abnormal liver function in 8 cases (73%) and diarrhoea in 1 case (9%), both of which resolved after drug intervention. Conclusion: The PFS of EGFR-mutated advanced NSCLC treated with allogenic CD8+ NKT cells combined with gefitinib was longer than that of gefitinib alone. No obvious serious adverse reactions occurred, and the patients compliance and survival status were good.<\/jats:p>","DOI":"10.1177\/15330338241273198","type":"journal-article","created":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T20:29:18Z","timestamp":1724272158000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["EGFR-TKIs Combined with Allogeneic CD8+ NKT Cell Immunotherapy to Treat Patients with Advanced EGFR-Mutated Lung Cancer"],"prefix":"10.1177","volume":"23","author":[{"given":"Fei","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Pharmacy, School of Pharmacy, Jiangsu University, Zhenjiang, China"},{"name":"Department of pharmacy, The Affiliated Hospital of Jiangsu University, Zhenjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Yuan","sequence":"additional","affiliation":[{"name":"Institute of Oncology, The Affiliated Hospital of Jiangsu University, Zhenjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanjun","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yali","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaoming","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqin","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Oncology, The Affiliated Hospital of Jiangsu University, Zhenjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Respiratory, The Affiliated Hospital of Jiangsu University, Zhenjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunhua","family":"Dai","sequence":"additional","affiliation":[{"name":"Institute of Oncology, The Affiliated Hospital of Jiangsu University, Zhenjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fenhong","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Respiratory, The Affiliated Hospital of Jiangsu University, Zhenjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junrong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Medicine, Jiangsu University, Zhenjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiujuan","family":"Fan","sequence":"additional","affiliation":[{"name":"Institute of Oncology, The Affiliated Hospital of Jiangsu University, Zhenjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuepeng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Oncology, The Affiliated Hospital of Jiangsu University, Zhenjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongfang","family":"Dai","sequence":"additional","affiliation":[{"name":"Institute of Oncology, The Affiliated Hospital of Jiangsu University, Zhenjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deqiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Oncology, The Affiliated Hospital of Jiangsu University, Zhenjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Oncology, The Affiliated Hospital of Jiangsu University, Zhenjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0663-6988","authenticated-orcid":false,"given":"Sheng","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minghui","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Medicine, Tsinghua University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,8,21]]},"reference":[{"issue":"1","key":"bibr1-15330338241273198","doi-asserted-by":"crossref","DOI":"10.3322\/caac.21708","volume":"72","author":"Siegel RL","year":"2022","journal-title":"CA Cancer J Clin."},{"key":"bibr2-15330338241273198","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000002108"},{"issue":"4","key":"bibr3-15330338241273198","volume":"29","author":"Planchard D","year":"2018","journal-title":"Annals of Oncology : Official Journal of the European Society for Medical Oncology"},{"key":"bibr4-15330338241273198","author":"Zhao C","year":"2014","journal-title":"Nat Rev Cancer."},{"issue":"22","key":"bibr5-15330338241273198","doi-asserted-by":"crossref","first-page":"6770","DOI":"10.1158\/0008-5472.CAN-13-1145","volume":"73","author":"Cho J","year":"2013","journal-title":"Cancer Res."},{"issue":"37","key":"bibr6-15330338241273198","volume":"113","author":"Han B","year":"2017","journal-title":"Lung Cancer"},{"key":"bibr7-15330338241273198","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000033"},{"issue":"3","key":"bibr8-15330338241273198","doi-asserted-by":"crossref","DOI":"10.1016\/j.cllc.2019.12.003","volume":"21","author":"Shah R","year":"2020","journal-title":"Clin Lung Cancer."},{"key":"bibr9-15330338241273198","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr.2016.12.02"},{"key":"bibr10-15330338241273198","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2019.10.019"},{"issue":"8","key":"bibr11-15330338241273198","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1158\/1078-0432.CCR-19-2027","volume":"26","author":"Isomoto K","year":"2020","journal-title":"Clinical Cancer Research : An Official Journal of the American Association for Cancer Research"},{"key":"bibr12-15330338241273198","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2018.11.021"},{"issue":"7","key":"bibr13-15330338241273198","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1007\/s00262-017-1986-y","volume":"66","author":"Okita R","year":"2017","journal-title":"Cancer Immunology, Immunotherapy : CII"},{"key":"bibr14-15330338241273198","doi-asserted-by":"crossref","first-page":"102085","DOI":"10.1016\/j.ctrv.2020.102085","volume":"89","author":"Passaro A","year":"2020","journal-title":"Cancer Treat Rev."},{"issue":"2","key":"bibr15-15330338241273198","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.jtho.2016.10.007","volume":"12","author":"Lee CK","year":"2017","journal-title":"J Thorac Oncol."},{"key":"bibr16-15330338241273198","doi-asserted-by":"crossref","unstructured":"Ji M, Liu Y, Li Q, et al. PD-1\/PD-L1 expression in non-small-cell lung cancer and its correlation with EGFR\/KRAS mutations. Cancer Biol Ther. 2016;17(4):407\u2010413. doi:https:\/\/doi.org\/10.1080\/15384047.2016.1156256","DOI":"10.1080\/15384047.2016.1156256"},{"issue":"3","key":"bibr17-15330338241273198","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1158\/1078-0432.CCR-18-1102","volume":"25","author":"Michael O","year":"2019","journal-title":"Clin Cancer Res."},{"issue":"12","key":"bibr18-15330338241273198","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/S2213-2600(15)00464-6","volume":"3","author":"Gourd K","year":"2015","journal-title":"Lancet Respir Med."},{"issue":"5","key":"bibr19-15330338241273198","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.jtho.2019.02.001","volume":"14","author":"Yang JC","year":"2019","journal-title":"Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer"},{"key":"bibr20-15330338241273198","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2018.05.015"},{"issue":"9","key":"bibr21-15330338241273198","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.297","volume":"7","author":"Dominguez C","year":"2016","journal-title":"Cell Death Dis."},{"key":"bibr22-15330338241273198","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/1479-5876-11-186","volume":"11","author":"He S","year":"2013","journal-title":"J Transl Med."},{"issue":"9","key":"bibr23-15330338241273198","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1158\/2326-6066.CIR-21-0751","volume":"10","author":"Nishii K","year":"2022","journal-title":"Cancer Immunol Res."},{"key":"bibr24-15330338241273198","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32191"},{"key":"bibr25-15330338241273198","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01869"},{"key":"bibr26-15330338241273198","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3389\/fimmu.2018.00367","volume":"9","author":"Dani?Lle K","year":"2018","journal-title":"Front Immunol"},{"key":"bibr27-15330338241273198","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-043737"},{"key":"bibr28-15330338241273198","doi-asserted-by":"crossref","first-page":"620374","DOI":"10.3389\/fimmu.2020.620374","volume":"11","author":"Stevens D","year":"2021","journal-title":"Front Immunol."},{"issue":"8","key":"bibr29-15330338241273198","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1007\/s00262-019-02363-3","volume":"68","author":"Li Z","year":"2019","journal-title":"Cancer Immunology, Immunotherapy : CII"},{"key":"bibr30-15330338241273198","author":"Gaafar RM, Surmont VF, Scagliotti GV","year":"2011","journal-title":"Eur J Cancer."},{"key":"bibr31-15330338241273198","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909530"},{"issue":"1","key":"bibr32-15330338241273198","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1186\/s12885-021-08590-1","volume":"21","author":"Yu W","year":"2021","journal-title":"BMC Cancer"},{"key":"bibr33-15330338241273198","doi-asserted-by":"crossref","unstructured":"Schulz KF, Altman DG, Moher D, et al. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. Br Med J. 2010 Mar 23:340\u2010332.","DOI":"10.1136\/bmj.c332"},{"issue":"2","key":"bibr34-15330338241273198","doi-asserted-by":"crossref","first-page":"0","DOI":"10.1016\/j.ejca.2008.10.026","volume":"45","author":"Eisenhauer EA","year":"2009","journal-title":"Eur J Cancer."},{"key":"bibr35-15330338241273198","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2947"},{"issue":"1","key":"bibr36-15330338241273198","doi-asserted-by":"crossref","DOI":"10.1136\/esmoopen-2017-000168","volume":"2","author":"Patil VM","year":"2017","journal-title":"Esmo Open"},{"key":"bibr37-15330338241273198","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12278"},{"issue":"16","key":"bibr38-15330338241273198","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.2165\/10489100-000000000-00000","volume":"69","author":"Sanford M","year":"2009","journal-title":"Drugs"},{"key":"bibr39-15330338241273198","doi-asserted-by":"crossref","unstructured":"To KKW, Fong W, Cho WCS. Immunotherapy in treating EGFR-mutant lung cancer: Current challenges and new strategies. Front Oncol. 2021 May 25;11:635007. doi:https:\/\/doi.org\/10.3389\/fonc.2021.635007","DOI":"10.3389\/fonc.2021.635007"},{"issue":"6","key":"bibr40-15330338241273198","first-page":"910","volume":"10","author":"Chen N","year":"2015","journal-title":"J Thorac Oncol Official Publ Int Assoc Study Lung Cancer"},{"issue":"1","key":"bibr41-15330338241273198","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/bjc.2014.555","volume":"112","author":"D'Incecco MA A","year":"2015","journal-title":"Br J Cancer."},{"issue":"5","key":"bibr42-15330338241273198","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/s41388-021-02124-6","volume":"41","author":"Lu Y","year":"2022","journal-title":"Oncogene"},{"key":"bibr43-15330338241273198","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2011.11.012"},{"key":"bibr44-15330338241273198","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/978-3-319-91442-8_16","volume":"211","author":"Justyna Rawluk CFW","year":"2018","journal-title":"Recent Results Cancer Res"},{"issue":"8","key":"bibr45-15330338241273198","first-page":"1303","volume":"68","author":"Li Z","year":"2019","journal-title":"Springer Open Choice"},{"key":"bibr46-15330338241273198","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00191"},{"key":"bibr47-15330338241273198","volume":"15","author":"Zhang H","journal-title":"J Thorac Oncol"},{"key":"bibr48-15330338241273198","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2020.04.004"},{"issue":"5","key":"bibr49-15330338241273198","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.4103\/jcrt.JCRT_1205_21","volume":"19","author":"Kolluri S","year":"2023","journal-title":"J Cancer Res Ther"},{"key":"bibr50-15330338241273198","doi-asserted-by":"crossref","DOI":"10.1016\/j.lungcan.2019.09.017","volume":"137","author":"Gelatti A","year":"2019","journal-title":"Lung Cancer"},{"issue":"5","key":"bibr51-15330338241273198","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.jtho.2018.02.022","volume":"13","author":"Spigel DR","year":"2018","journal-title":"Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer"}],"container-title":["Technology in Cancer Research &amp; Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15330338241273198","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15330338241273198","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15330338241273198","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T06:15:18Z","timestamp":1777702518000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15330338241273198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":51,"alternative-id":["10.1177\/15330338241273198"],"URL":"https:\/\/doi.org\/10.1177\/15330338241273198","relation":{},"ISSN":["1533-0346","1533-0338"],"issn-type":[{"value":"1533-0346","type":"print"},{"value":"1533-0338","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"article-number":"15330338241273198"}}