{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:33:37Z","timestamp":1777941217501,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technol Cancer Res Treat"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:p>\n                    <jats:bold>Objectives<\/jats:bold>\n                    : The contemporary concept of carcinogenesis summarizes the role of hypoxia, neoangiogenesis, and hemostasis, including in the stage of progression and metastasis of the tumor process. Metastatic disease is a serious therapeutic challenge for any oncological condition. The purpose of this study was to evaluate the dynamics of specific indicators of neoangiogenesis and hypoxia as potential biomarkers for therapeutic efficacy or risk of disease progression in patients with brain metastases (BM) undergoing robotic stereotactic radiosurgery.\n                    <jats:bold>Methods:<\/jats:bold>\n                    Two groups of patients (lung cancer and other types of cancers) with oligometastatic disease and brain metastases were included. The patients (n=66) were treated with CyberKnife system. Human Angiopoietin-2, Hypoxia inducible factor 1 \u03b1 (HIF-1\u03b1) and human Vascular Endothelial Growth Factor-\u0410 (VEGF-\u0410) were measured in this prospective longitudinal study.\n                    <jats:bold>Results:<\/jats:bold>\n                    Analysis of human Angiopoietin-2, HIF-1\u03b1, human VEGF-A in the post-treatment period showed a statistically significant decrease between the baseline and the 6 months post-treatment time point in both patient groups. The baseline value of serum VEGF-\u0410 in the group with lung cancer decreased by 40%, \u0410ngiopoietin-2-by 48%, HIF-1\u03b1 -by 43%. In the group with other types of cancers, VEGF-\u0410 decreased by 54.75%, \u0410ngiopoietin-2-by 52%, HIF-1\u03b1 -by 39.5%. Despite the significant reduction, the levels remained significantly higher in both groups than in healthy controls.\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    This study underscores the potential of integrating molecular markers like VEGF-A, Angiopoietin-2, and HIF-1\u03b1 into clinical decision-making to enhance outcomes for patients with brain metastases undergoing RSRS.\n                  <\/jats:p>","DOI":"10.1177\/15330338251313945","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T03:38:18Z","timestamp":1736739498000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Dynamics of VEGF-\u0410, \u0410ngiopoietin-2 and HIF-1\u03b1 Levels in Patients with Brain Metastases Treated with Cyberknife Radiosurgery"],"prefix":"10.1177","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6423-9665","authenticated-orcid":false,"given":"Veselin","family":"Popov","sequence":"first","affiliation":[{"name":"Medical University of Plovdiv"},{"name":"UMHAT \u201cSv. Georgi\u201d- Plovdiv"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Raycheva","sequence":"additional","affiliation":[{"name":"Medical University of Plovdiv"},{"name":"UMHAT \u201cSv. Georgi\u201d- Plovdiv"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanet","family":"Grudeva-Popova","sequence":"additional","affiliation":[{"name":"Medical University of Plovdiv"},{"name":"UMHAT \u201cSv. Georgi\u201d- Plovdiv"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0055-y"},{"key":"e_1_3_3_3_2","unstructured":"American Cancer Society. 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Future Oncol (Future Medicine). 2015;11(24):3233\u20133242. doi:10.2217\/fon.15.207","journal-title":"Future Oncol (Future Medicine)"},{"issue":"1","key":"e_1_3_3_14_2","first-page":"622","article-title":"Predictive potential of markers of coagulation, fibrinolysis and angiogenesis in cancer patients","volume":"100","author":"Beleva \u0415","year":"2015","unstructured":"Beleva \u0415, Deneva \u0422, Karaslavova \u0415, Popov V, Grudeva-Popova Z. Predictive potential of markers of coagulation, fibrinolysis and angiogenesis in cancer patients. 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