{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T03:19:45Z","timestamp":1778901585110,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Changzhou Social Development Program","award":["No. CE20235063"],"award-info":[{"award-number":["No. CE20235063"]}]},{"name":"the National Natural Science Foundation of Jiangsu","award":["No. BK20231190"],"award-info":[{"award-number":["No. BK20231190"]}]},{"name":"Jiangsu Provincial Medical Key Discipline Cultivation Unit of Oncology Therapeutics","award":["No. JSDW202237"],"award-info":[{"award-number":["No. JSDW202237"]}]},{"name":"Jiangsu Provincial Key Research and Development Program Social Development Project","award":["No. BE2022720"],"award-info":[{"award-number":["No. BE2022720"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No. 62371243"],"award-info":[{"award-number":["No. 62371243"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technol Cancer Res Treat"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Multiple targets with varying distances are common in radiotherapy. Reducing treatment time in the plan design helps minimize patient movement and discomfort during the treatment process. This retrospective study aimed to investigate the impact of varying intertarget distances (ITDs) on the dosimetric differences and delivery efficiency of two single-isocenter techniques.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>ITDs for 15 patients with dual-site vertebral metastases undergoing volume-modulated arc therapy (VMAT) were modified using Matlab 2019a. Distances of 2, 4, 6, 8, and 10 cm were considered. The VMAT plans were designed with a prescription dose of 40 Gy\/20f on Infinity Linac and Monaco 5.40.01. Single-isocenter with jaw tracking (VMAT1) and fixed jaw (VMAT2) were compared in terms of dosimetry and delivery efficiency under different ITDs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Results showed that both VMAT plans exhibited dosimetric parameters meeting clinical requirements. The conformity index (CI) of VMAT1 plans was smaller than that of VMAT2 at ITD\u2009=\u20094, 6, and 8 cm (P\u2009=\u20090.007, 0.020, and 0.039, respectively), with no significant differences in other planning target volume dosimetry parameters. In terms of delivery efficiency, the treatment time of VMAT1 increased significantly when ITD\u2009&gt;\u20092 cm compared with that at ITD\u2009=\u20092 cm (P\u2009=\u20090.000). Conversely, VMAT2 exhibited no significant change in treatment time at different ITDs (P\u2009=\u20090.073). For ITD\u2009=\u20092 cm, the treatment time of VMAT1 was shorter than that of VMAT2, with a median difference of 77 s. For ITD\u2009&gt;\u20092 cm, the treatment time of VMAT2 was shorter than that of VMAT1, with a median difference ranging from 65 s to 121 s.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The experimental results showed that the single-isocenter with jaw tracking is recommended in the planning design when ITDs are less than 2 cm. However, for ITDs greater than 2 cm, the single-isocenter with fixed jaw demonstrates high delivery efficiency.5075<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15330338251332386","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T03:57:36Z","timestamp":1744343856000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Intertarget Distances on Single-Isocenter Radiotherapy Plans with jaw-Tracking and jaw-Fixed Techniques for Vertebral Metastases"],"prefix":"10.1177","volume":"24","author":[{"given":"Ling","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Radiotherapy Oncology, The Affiliated Changzhou NO.2 People's Hospital of Nanjing Medical University, Changzhou, China"},{"name":"Jiangsu Province Engineering Research Center of Medical Physics, Changzhou, 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