{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:34:10Z","timestamp":1777941250203,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technol Cancer Res Treat"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Current evidence from evidence-based medicine is limited regarding the efficacy and safety of immunotherapy in elderly patients aged 75 years and older with malignant solid tumors. PRaG therapy, which combines PD-1\/PD-L1 inhibitors, radiotherapy, and granulocyte-macrophage colony-stimulating factor (GM-CSF), aims to treat patients with advanced, refractory tumors. Preliminary findings indicate that patients aged 75 years and older can benefit from this treatment and can tolerate it well.\n                    <jats:bold>Objective:<\/jats:bold>\n                    This study aims to evaluate the efficacy and safety of the PRaG regimen in elderly patients with advanced malignant solid tumors to provide evidence-based support for immunotherapy in this population.\n                    <jats:bold>Methods and Analysis:<\/jats:bold>\n                    This study involves a multicenter, prospective, single-arm phase II clinical trial designed to enroll 29 patients aged 75 years and older with either newly diagnosed or recurrent metastatic advanced solid tumors that are histologically confirmed. All of the eligible patients will have had to receive at least two cycles of PRaG therapy until disease progression or intolerable adverse effects occurred. The study protocol was approved on September 12, 2023, by the Ethics Committee of the Second Affiliated Hospital of Soochow University (JD-LK-2023-082-I01) and by the ethics committees of all of the participating centers (Trial Registration Number: NCT06112041).\n                  <\/jats:p>","DOI":"10.1177\/15330338251400412","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T18:10:36Z","timestamp":1764267036000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of PRaG Therapy in Elderly Patients with Advanced Malignant Tumors: A Prospective, Multicenter Clinical Study Protocol (PRaG 9.0 Study)"],"prefix":"10.1177","volume":"24","author":[{"given":"Xiangrong","family":"Zhao","sequence":"first","affiliation":[{"name":"The Second Af\ufb01liated Hospital of Soochow University"},{"name":"Soochow University"},{"name":"Soochow University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MengMeng","family":"Yang","sequence":"additional","affiliation":[{"name":"The Second Af\ufb01liated Hospital of Soochow University"},{"name":"Soochow University"},{"name":"Soochow University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junjun","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Second Af\ufb01liated Hospital of Soochow University"},{"name":"Soochow University"},{"name":"Soochow University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuehong","family":"Kong","sequence":"additional","affiliation":[{"name":"The Second Af\ufb01liated Hospital of Soochow University"},{"name":"Soochow University"},{"name":"Soochow University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiling","family":"Xu","sequence":"additional","affiliation":[{"name":"The Second Af\ufb01liated Hospital of Soochow University"},{"name":"Soochow University"},{"name":"Soochow University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongzheng","family":"Chen","sequence":"additional","affiliation":[{"name":"The Second Af\ufb01liated Hospital of Soochow University"},{"name":"Soochow University"},{"name":"Soochow University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Yin","sequence":"additional","affiliation":[{"name":"The Second Af\ufb01liated Hospital of Soochow University"},{"name":"Soochow University"},{"name":"Soochow University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumeng","family":"Wang","sequence":"additional","affiliation":[{"name":"The Second Af\ufb01liated Hospital of Soochow University"},{"name":"Soochow University"},{"name":"Soochow University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangqiang","family":"Chen","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Soochow University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengfei","family":"Xing","sequence":"additional","affiliation":[{"name":"The Second Af\ufb01liated Hospital of Soochow University"},{"name":"Soochow University"},{"name":"Soochow University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7469-1743","authenticated-orcid":false,"given":"Liyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Second Af\ufb01liated Hospital of Soochow University"},{"name":"Soochow University"},{"name":"Soochow University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,11,27]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.952066"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.01625"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.926740"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1078915"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v30.i9.1237"},{"issue":"44","key":"e_1_3_3_7_2","first-page":"3584","article-title":"PRag treatment for a case of advanced refractory non-small cell lung cancer with resistance to PD-1 and PD-L1 inhibitors","volume":"103","author":"Xu M","year":"2023","unstructured":"Xu M, Zhang C, Xing P, Zhang L. 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