{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:34:13Z","timestamp":1777941253247,"version":"3.51.4"},"reference-count":50,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100014481","name":"Kite Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014481","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technol Cancer Res Treat"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin-lymphoma. Although it can be cured in many patients, a significant proportion of patients fail the primary treatment and require second-line treatment. Currently, only limited data on real-world outcomes with standard therapies in Austrian patients with DLBCL are available, and while novel therapies are emerging, no historical benchmarks have been established to serve as a reference for these novel treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective, single-center analysis of patients with DLBCL diagnosed between 2010 and 2018 who had been treated with standard therapies. To establish efficacy benchmarks for novel therapies, we applied both clinical-trial and real-world-derived criteria to analyze the outcomes of patients potentially eligible for novel or future treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Although many patients can be cured with frontline therapy, outcomes are poor, especially in high-risk patients. Patients failing frontline therapy, especially those fulfilling the chimeric antigen-receptor (CAR) T-cell eligibility criteria, had dismal outcomes, and very few patients achieved long-term remission. Our data provide benchmark outcomes for patients eligible for novel treatments such as antibody-drug-conjugate (ADC) or CAR T-cell therapy-based treatments for potential future comparative analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with DLBCL treated in Austria showed comparable outcomes to those reported in other real-world studies. Overall, standard chemotherapy-based approaches provide unsatisfactory outcomes in high-risk patients and patients in whom frontline therapy fails. Because many patients are now eligible for alternative first- and second-line treatments, such as ADC-based or CAR T-cell therapy, our efficacy benchmarks can serve for the future evaluation of these therapies in the Austrian healthcare environment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15330338251410356","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T17:57:42Z","timestamp":1767895062000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Historic Real-World Outcomes and Future Benchmarks for Patients with Diffuse Large B-Cell Lymphoma Receiving First- and Second-Line Therapy in Austria \u2013 a Large Single-Center Experience"],"prefix":"10.1177","volume":"25","author":[{"given":"Michael","family":"Leisch","sequence":"first","affiliation":[{"name":"Paracelsus Medical University Hospital"},{"name":"Salzburg Cancer Research Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8204-0334","authenticated-orcid":false,"given":"Dominik","family":"Kiem","sequence":"additional","affiliation":[{"name":"Paracelsus Medical University Hospital"},{"name":"Salzburg Cancer Research Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Grabmer","sequence":"additional","affiliation":[{"name":"Paracelsus Medical University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton","family":"Kugler","sequence":"additional","affiliation":[{"name":"Paracelsus Medical University Salzburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianfranco","family":"Pocobelli","sequence":"additional","affiliation":[{"name":"Salzburg Cancer Research Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayer","family":"Marie-Christina","sequence":"additional","affiliation":[{"name":"Paracelsus Medical University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0485-1462","authenticated-orcid":false,"given":"Bernd","family":"Sch\u00f6pf","sequence":"additional","affiliation":[{"name":"Kite, a Gilead Company"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Egle","sequence":"additional","affiliation":[{"name":"Paracelsus Medical University Hospital"},{"name":"Salzburg Cancer Research Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Greil","sequence":"additional","affiliation":[{"name":"Paracelsus Medical University Hospital"},{"name":"Salzburg Cancer Research Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Melchardt","sequence":"additional","affiliation":[{"name":"Paracelsus Medical University Hospital"},{"name":"Salzburg Cancer Research Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2027612"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12254-022-00859-w"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdp145"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2022.102443"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2115304"},{"key":"e_1_3_4_7_2","unstructured":"Lenz GC Gla\u00df B Keil F et al. 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