{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:52:21Z","timestamp":1790272341581,"version":"4.1.0"},"reference-count":50,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100010223","name":"Stiftelsen Jubileumsklinikens Forskningsfond mot Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010223","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Marsha Rivkin Center for Ovarian Cancer Research"},{"DOI":"10.13039\/501100011727","name":"Stockholm l\u00e4ns landsting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011727","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technol Cancer Res Treat"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Ovarian cancer is a major global concern. Due to late detection, it is one of the few malignancies for which the five-year survival rate continues to be low without appreciable improvement in recent decades. Screening methods are needed that non-invasively, without ionizing radiation, detect early-stage ovarian cancer with clear distinction from benign lesions. Magnetic resonance spectroscopy (MRS) could be a key contributor to early ovarian cancer detection, insofar as data analysis and interpretation after appropriate signal processing are implemented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The derivative non-parametric and parametric fast Pad\u00e9 transform (dFPT) and the derivative fast Fourier transform (dFFT: optimized, unoptimized) are applied to proton MRS time signals encoded from the ovary. These include in vivo MRS for a borderline cyst, and in vitro MRS for serous cystic adenoma and serous cystic adenocarcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>On a broad chemical shift axis (aliphatic and aromatic), over 300 thin, clearly-delineated peaks are baseline-resolved and displayed in a readily amenable form for clinical interpretation. This is from the in vivo encoding. Clearly quantifiable peaks include cancer biomarkers: total choline components (phosphocholine, glycerophosphocholine, free choline) and the lactate doublet, as well as other diagnostically-relevant metabolites in spectrally-crowded regions. Concordance among three algorithms (parametric and non-parametric dFPT as well as optimized dFFT) provides cross-validation, essential for clinical trustworthiness of derivative MRS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>With these results that help benchmark derivative MRS for clinical applications in oncology, the time is deemed ripe to implement the stated advances. More effective early detection of ovarian cancer should be among the most urgent priorities for this upgrade.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15330338251410459","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T10:16:25Z","timestamp":1767089785000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["The Potential for Enhanced Ovarian Cancer Diagnostics Through Optimized Derivative Magnetic Resonance Spectroscopy"],"prefix":"10.1177","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6795-7793","authenticated-orcid":false,"given":"D\u017eevad","family":"Belki\u0107","sequence":"first","affiliation":[{"name":"Karolinska Institute"},{"name":"Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Belki\u0107","sequence":"additional","affiliation":[{"name":"Karolinska Institute"},{"name":"Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden"},{"name":"School of Community and Global Health, Claremont Graduate University, Claremont, California, USA"},{"name":"Institute for Prevention Research, School of Medicine, University of Southern California, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,12,30]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.34002"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-19-0184"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1515\/hmbci-2019-0038"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gore.2024.101376"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3182755e14"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00731-5"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2016.0122"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1503523"},{"issue":"4","key":"e_1_3_4_10_2","article-title":"The Angelina Jolie effect in Jewish law: Prophylactic mastectomy and oophorectomy in BRCA carriers","volume":"6","author":"Grossman SG","year":"2015","unstructured":"Grossman SG. The Angelina Jolie effect in Jewish law: Prophylactic mastectomy and oophorectomy in BRCA carriers. Rambam Maimonides Med J. 2015;6(4).","journal-title":"Rambam Maimonides Med J"},{"key":"e_1_3_4_11_2","first-page":"567","article-title":"Handling individuals with high cancer risk: One size doesn't fit all","volume":"18","author":"Rennert G","year":"2016","unstructured":"Rennert G. Handling individuals with high cancer risk: One size doesn't fit all. Isr Med Assoc J. 2016;18:567-568.","journal-title":"Isr Med Assoc J"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980501)82:9<1731::AID-CNCR20>3.0.CO;2-4"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0b013e31821690ef"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10910-016-0694-8"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1201\/9781439806456"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20842"},{"key":"e_1_3_4_17_2","unstructured":"Ojo AC. The Analysis and Automatic Classification of Nuclear Magnetic Resonance Signals. PhD Thesis The University of Edinburgh (2010). Edinburgh Research Archive (http:\/\/ hdl.handle.net\/1842\/4109)."},{"key":"e_1_3_4_18_2","unstructured":"Zhang JM. Human brain glutamate glutamine \u03b3-aminobutyric acid: Proton magnetic resonance spectral quantification with the fast Pad\u00e9 transform. PhD Thesis. University of California Los Angeles (2013). (scholarship.org\/uc\/item\/1np12339)."},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.18383\/j.tom.2016.00154"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.3233\/THC-181535"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.7785\/tcrt.2012.500401"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nima.2017.07.034"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10910-019-01001-8"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.aiq.2021.05.001"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.aiq.2022.08.001"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10910-025-01733-w"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1090\/S0025-5718-1965-0178586-1"},{"key":"e_1_3_4_28_2","article-title":"STARD 2015: An updated list of essential items for reporting diagnostic accuracy studies","volume":"351","author":"Bossuyt PM","year":"2015","unstructured":"Bossuyt PM, Reitsma JB, Bruns DE, et al. STARD 2015: An updated list of essential items for reporting diagnostic accuracy studies. Br Med J. 2015;351:h5527.","journal-title":"Br Med J."},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-012799"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1137\/0134048"},{"key":"e_1_3_4_31_2","volume-title":"Numerical Recipes in FORTRAN. The Art of Scientific Computing","author":"Press WH","year":"2007","unstructured":"Press WH, Teukolsy SA, Vetterling WT, Flannery BP. Numerical Recipes in FORTRAN. The Art of Scientific Computing. 3rd edition. Cambridge University Press; 2007.","edition":"3"},{"key":"e_1_3_4_32_2","unstructured":"MATLAB version: 9. 13. 0 (R2022b). Natick Massachusetts: The MathWorks Inc 2022."},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1417"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/1099-1492(200008)13:5<297::AID-NBM648>3.0.CO;2-I"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6891"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/174019"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2023-004610"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.26541"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2016.00153"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-53632-7.00324-5"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1162\/1535350042973517"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4112"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20190134"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10910-024-01597-6"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-12-39"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.3892\/or.2012.2071"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202101993RR"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12551-020-00758-6"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol31120592"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0b013e318251cbc2"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-018-5314-5"}],"container-title":["Technology in Cancer Research &amp; Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15330338251410459","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15330338251410459","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15330338251410459","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T06:17:27Z","timestamp":1777702647000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15330338251410459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":50,"alternative-id":["10.1177\/15330338251410459"],"URL":"https:\/\/doi.org\/10.1177\/15330338251410459","relation":{},"ISSN":["1533-0346","1533-0338"],"issn-type":[{"value":"1533-0346","type":"print"},{"value":"1533-0338","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]},"article-number":"15330338251410459"}}