{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:30:48Z","timestamp":1777984248515,"version":"3.51.4"},"reference-count":60,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Bionirs Arg SA"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technol Cancer Res Treat"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This work introduces MamoRef, an innovative whole-field, near infrared spectroscopy based device for adjunctive breast examination, aiming to help classify benign and malignant lesions in women. Utilizing low-power, non-ionizing red and near-infrared lasers, it provides metabolic information to aid physicians in characterizing lesions in BI-RADS II to IV patients, offering a non-invasive screening alternative.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Approach<\/jats:title>\n                    <jats:p>Clinical studies were conducted, benchmarking MamoRef against conventional imaging and core biopsies. The device generates 2D maps of relative oxyhemoglobin, deoxyhemoglobin, and oxygen saturation. NIRS-specialized professionals, with basic clinical training, independently scored MamoRef images using a 6-point scale analog to BI-RADS. Scores were averaged and normalized for biopsy comparison.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main results<\/jats:title>\n                    <jats:p>The studied clinical cases show promising outcomes. For neoproliferative lesions, MamoRef images reveals high deoxygenated hemoglobin and diffuse high oxygenated\/total hemoglobin, suggesting neovascularization around necrotic tissue. Preliminary receiver operating characteristic analysis yielded an area under the curve of 0.77. At a 0.6 threshold, MamoRef showed 70% accuracy and 74% specificity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Preliminary results suggest MamoRef can potentially differentiate benign from malignant lesions detected by standard imaging. Trained clinicians might detect and characterize lesions using these metabolic maps. Further larger-scale studies are needed to validate these findings and improve the technology, positioning MamoRef as a potential low-cost, accessible adjunctive screening tool.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15330338261417262","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T17:30:55Z","timestamp":1770399055000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Whole-Field Continuous Wave Diffuse Reflectance Imaging for Breast Lesion Characterization: Clinical Results"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5452-1165","authenticated-orcid":false,"given":"Nicol\u00e1s A.","family":"Carbone","sequence":"first","affiliation":[{"name":"Centro de Investigaciones en F\u00edsica e Ingenier\u00eda del Centro de la Provincia de Buenos Aires (CIFICEN, UNCPBA - CICPBA - CONICET), Tandil, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6788-888X","authenticated-orcid":false,"given":"Demi\u00e1n A.","family":"Vera","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones en F\u00edsica e Ingenier\u00eda del Centro de la Provincia de Buenos Aires (CIFICEN, UNCPBA - CICPBA - CONICET), Tandil, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9888-7740","authenticated-orcid":false,"given":"M. Victoria","family":"Waks-Serra","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones en F\u00edsica e Ingenier\u00eda del Centro de la Provincia de Buenos Aires (CIFICEN, UNCPBA - CICPBA - CONICET), Tandil, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5142-7149","authenticated-orcid":false,"given":"H\u00e9ctor A.","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones en F\u00edsica e Ingenier\u00eda del Centro de la Provincia de Buenos Aires (CIFICEN, UNCPBA - CICPBA - CONICET), Tandil, Argentina"},{"name":"Thayer School of Engineering at Dartmouth College, Hanover, NH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela I.","family":"Iriarte","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones en F\u00edsica e Ingenier\u00eda del Centro de la Provincia de Buenos Aires (CIFICEN, UNCPBA - CICPBA - CONICET), Tandil, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan A.","family":"Pomarico","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones en F\u00edsica e Ingenier\u00eda del Centro de la Provincia de Buenos Aires (CIFICEN, UNCPBA - CICPBA - CONICET), Tandil, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4893-3374","authenticated-orcid":false,"given":"Nora","family":"Fuentes","sequence":"additional","affiliation":[{"name":"Hospital Privado de la Comunidad, Mar del Plata, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda E.","family":"Renati","sequence":"additional","affiliation":[{"name":"Hospital Privado de la Comunidad, Mar del Plata, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo H.","family":"Capellino","sequence":"additional","affiliation":[{"name":"Hospital Privado de la Comunidad, Mar del Plata, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romina","family":"Osses","sequence":"additional","affiliation":[{"name":"Hospital Privado de la Comunidad, Mar del Plata, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela A.","family":"Pardini","sequence":"additional","affiliation":[{"name":"Bionirs Arg SA, Tandil, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In\u00e9s","family":"Hope","sequence":"additional","affiliation":[{"name":"Bionirs Arg SA, Tandil, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"key":"e_1_3_4_2_2","unstructured":"International Agency for Research in Cancer. 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