{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:43:46Z","timestamp":1793295826827,"version":"4.5.0"},"reference-count":49,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technol Cancer Res Treat"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Blood perfusion insufficiency and hypoxia are the main causes of drug resistance to chemotherapy in breast cancer. Increasing blood perfusion can improve drug delivery. This study aimed to investigate the effects of ultrasound-stimulated microbubbles (USMBs) on hemoperfusion in invasive breast cancer (IBC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this prospective clinical trial, 36 patients diagnosed with IBC were enrolled sequentially. The treatment group (n\u2009=\u200918, enrolled from June 2022 to April 2025) were treated with SonoVue\n                      <jats:sup>\u00ae<\/jats:sup>\n                      microbubbles (MBs) stimulated by ultrasound, with a mechanical index (MI) of 0.2\u20130.3: 1\u2005mL of SonoVue\n                      <jats:sup>\u00ae<\/jats:sup>\n                      MBs was injected at 3.5-min intervals three times for a USMB treatment lasting 10\u2005min. The control group (n\u2009=\u200918, enrolled from May to November 2025) received identical MB injections without ultrasound stimulation. Contrast-enhanced ultrasound (CEUS) was used to evaluate the changes in blood perfusion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the treatment group, in comparison with the pre-treatment findings, the tumor perfusion area expanded (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001) and the time to peak (TTP) increased (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.05) after USMB treatment. For regions exhibiting low enhancement inside the lesion on CEUS before USMB treatment, the area under the curve (AUC) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001) and mean transit time (MTT) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.05) both increased following therapy. In the control group, none of the parameters showed statistically significant differences after the MB injections.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>USMB treatment can improve blood perfusion in IBC, especially by enhancing the AUC and MTT in hypoperfused regions. These findings highlight the potential of USMB treatment as a noninvasive technique to enhance intratumoral drug delivery, although further validation of this approach is required.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Clinical trial registration number:<\/jats:bold>\n                      NCT06158217.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15330338261423051","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T05:23:19Z","timestamp":1770614599000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Ultrasound Combined with Microbubbles on Blood Perfusion in Invasive Breast Cancer\u2014A Prospective Clinical 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