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In-depth understanding of molecular pathways associated with increased aerobic glycolysis in TNBCs could provide key insights into the drivers of TNBC progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      \u03b2-catenin and glycolytic proteins (PFKP, LDHA, MCT1) were assessed by Immunohistochemistry (IHC) in TNBC patients (n\u2009=\u200998), with prognostic value evaluated by Kaplan-Meier and Cox regression.\n                      <jats:italic toggle=\"yes\">In vitro<\/jats:italic>\n                      , the \u03b2-catenin inhibitor ie, XAV939 was tested for suppressing \u03b2-catenin-driven aerobic glycolysis in TNBC models using MTT for proliferation, Western blotting for protein expression, and wound healing, droplet invasion, and colony formation assays for physiological changes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      \u03b2-catenin and glycolytic markers (PFKP, LDHA, MCT1) were overexpressed in &gt;50% of TNBCs. Kaplan-Meier and Cox regression analyses showed that combined expression of \u03b2-catenin with glycolytic markers correlated with reduced survival.\n                      <jats:italic toggle=\"yes\">In vitro<\/jats:italic>\n                      , XAV939 suppressed \u03b2-catenin-driven aerobic glycolysis in TNBC cells, downregulating \u03b2-catenin and glycolytic proteins, reducing glycolytic activity, and impairing aggressive phenotypes (proliferation, migration, invasion, clonogenicity).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Overall, our results highlight the crucial role of \u03b2-catenin in controlling aerobic glycolysis via regulation of key glycolytic proteins, thereby positively driving the progression and metastasis of TNBCs. Additionally, our data strongly establish that XAV939 effectively inhibits glycolytic phenotype, thereby suggesting its therapeutic potential in TNBC patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15330338261425407","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T14:35:48Z","timestamp":1771338948000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["\u03b2-Catenin\u2013Facilitated Glycolytic Reprogramming Fuels TNBC Progression: Therapeutic Blockade with XAV939"],"prefix":"10.1177","volume":"25","author":[{"given":"Sheikh Mohammad","family":"Umar","sequence":"first","affiliation":[{"name":"Dr BRA IRCH, AIIMS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shruti","family":"Kahol","sequence":"additional","affiliation":[{"name":"AIIMS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep R.","family":"Mathur","sequence":"additional","affiliation":[{"name":"AIIMS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Gogia","sequence":"additional","affiliation":[{"name":"Dr BRA IRCH, AIIMS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.V.S.","family":"Deo","sequence":"additional","affiliation":[{"name":"Dr BRA IRCH, AIIMS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivam","family":"Pandey","sequence":"additional","affiliation":[{"name":"AIIMS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4911-7483","authenticated-orcid":false,"given":"Chandra Prakash","family":"Prasad","sequence":"additional","affiliation":[{"name":"Dr BRA IRCH, AIIMS"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,17]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2024.102993"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2020.5135"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1405491"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.1060495"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1091779"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-021-06414-w"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-022-02851-6"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2022.10.001"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2017.08.009"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-024-09694-0"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/oncsis.2017.14"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-020-0440-y"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117097"},{"issue":"5","key":"e_1_3_4_15_2","first-page":"5285","article-title":"Co-activation of hedgehog and Wnt signaling pathways is associated with poor outcomes in triple negative breast cancer","volume":"14","author":"Arnold K","year":"2017","unstructured":"Arnold K, Pohlig R, Sims-Mourtada J. 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