{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:34:29Z","timestamp":1777941269417,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81860595"],"award-info":[{"award-number":["81860595"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100012547","name":"Natural Science Foundation of Guangxi Zhuang Autonomous Region","doi-asserted-by":"publisher","award":["2025GXNSFAA069044"],"award-info":[{"award-number":["2025GXNSFAA069044"]}],"id":[{"id":"10.13039\/100012547","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technol Cancer Res Treat"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>We introduce a standardized necrosis rate\u2014percent reduction in enhancing tumor diameter normalized by baseline tumor diameter\u2014with a threshold of \u226530%. This endpoint is derived from the mRECIST partial response criteria but is normalized to mitigate tumor size-dependent bias. A clinical\u2013radiomics model was developed to assess necrosis in hepatocellular carcinoma (HCC) patients treated with transarterial chemoembolization (TACE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospectively, 95 HCC patients undergoing TACE were included. Radiomics features were selected via LASSO regression, and clinical variables via logistic regression. Separate radiomics and clinical models were developed, and a combined model was constructed using multivariable logistic regression. The cohort was randomly split into training (70%) and validation (30%) sets, with all preprocessing, feature selection, and model training confined to the training set to prevent data leakage. Model performance was evaluated using discrimination (AUC), calibration, clinical utility (decision curve analysis), and a nomogram.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 1,316 extracted radiomics features, six were retained for Rad-score calculation. Key clinical predictors included hepatitis group, standardized viable tumor ratio, and vascular invasion. The integrated model achieved AUCs of 0.865 (95% CI: 0.768\u20130.961) in training and 0.853 (95% CI: 0.716\u20130.990) in validation (n=29), outperforming the clinical model (AUCs: 0.808 (95% CI: 0.695-0.922) and 0.666 (95% CI: 0.465-0.866), respectively). Decision curve analysis and calibration plots confirmed the combined model\u2019s superior performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The radiomics\u2013clinical nomogram, based on a standardized necrosis rate, may enable early prediction of TACE response, offering potential insights for therapeutic decision-making, risk stratification, and liver transplantation management. External validation is warranted before clinical application.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15330338261444986","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T09:39:31Z","timestamp":1776505171000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A Clinical\u2013Radiomics Nomogram Predicts Early Tumor Necrosis After Transarterial Chemoembolization for Hepatocellular Carcinoma"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1890-6326","authenticated-orcid":false,"given":"Xiang-ling","family":"Wu","sequence":"first","affiliation":[{"name":"Guangxi Medical University"},{"name":"Guangxi Zhuang Autonomous Region Center for Disease Prevention and Control (Guangxi Zhuang Autonomous Region Academy of Preventive Medicine)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing-Zhi","family":"Duan","sequence":"additional","affiliation":[{"name":"Tongren Second People\u2019s Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Hua","family":"Jiang","sequence":"additional","affiliation":[{"name":"Guangxi Zhuang Autonomous Region Center for Disease Prevention and Control (Guangxi Zhuang Autonomous Region Academy of Preventive Medicine)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan-shan","family":"Zeng","sequence":"additional","affiliation":[{"name":"The Second People\u2019s Hospital of China Three Gorges University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo-cheng","family":"Lin","sequence":"additional","affiliation":[{"name":"The Second People\u2019s Hospital of China Three Gorges University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong-liao","family":"Fang","sequence":"additional","affiliation":[{"name":"Guangxi Medical University"},{"name":"Guangxi Zhuang Autonomous Region Center for Disease Prevention and Control (Guangxi Zhuang Autonomous Region Academy of Preventive Medicine)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,4,18]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17050893"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ags3.12622"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2024.101216"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2023.0385"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-6265-1"},{"key":"e_1_3_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.03.007"},{"key":"e_1_3_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2018.02.013"},{"key":"e_1_3_8_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1354964"},{"key":"e_1_3_8_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-024-12049-4"},{"issue":"10","key":"e_1_3_8_11_2","first-page":"4956","article-title":"Complete response at first transarterial chemoembolization predicts favorable outcome in hepatocellular carcinoma","volume":"11","author":"Peng CW","year":"2021","unstructured":"Peng CW, Teng W, Lui KW, et al. 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