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On one hand, endogenous mechanical cues, such as matrix stiffness, fluid shear stress(FSS), and mechanical strain, have been shown to promote tumor cell malignant phenotypes, including proliferation, migration, 4 invasion, and drug resistance. These activities are primarily through mechano-transduction pathways involving integrin\u2013FAK and YAP\/TAZ. Meanwhile, mechanical microenvironment was also found to influence immune cell activity and tumor immune evasion. On the other hand, exogenous mechanical stimuli, such as magnetic fields and ultrasound, can be harnessed for therapeutic purposes by altering the tumor mechanical microenvironment in situ to enhance drug delivery or directly induce cell apoptosis. Furthermore, mechanical interventions exhibit synergistic effects when combined with conventional therapies like radiotherapy and chemotherapy, thereby amplifying antitumor efficacy. 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