{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T21:20:30Z","timestamp":1789075230810,"version":"build-2803163510"},"reference-count":43,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"National Key R&D Program of China, Ministry of Science and Technology of the People\u2019s Republic of China","award":["2022YFC2407100"],"award-info":[{"award-number":["2022YFC2407100"]}]},{"name":"National Key R&D Program of China, Ministry of Science and Technology of the People\u2019s Republic of China","award":["2022YFC2407101"],"award-info":[{"award-number":["2022YFC2407101"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["2025-PUMCH-A-029"],"award-info":[{"award-number":["2025-PUMCH-A-029"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technol Cancer Res Treat"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>To assess the impact of cisplatin cycles on overall survival (OS) and disease-free survival (DFS) in cervical cancer (CC) patients undergoing concurrent chemoradiotherapy (CCRT), and to build a nomogram-based prognostic stratification to identify CC patients who might benefit from \u2265 5 cycles of cisplatin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study retrospectively analyzed data from 918 patients who were treated with external beam radiotherapy and brachytherapy. Weekly cisplatin was the concurrent regimen. The difference in survival outcomes between the &lt; 5 cycles and \u2265 5 cycles groups were compared. Subgroup analysis was further conducted. Univariate and multivariate Cox regression analyses were performed in the &lt;5 cycles, and a nomogram was developed accordingly. The patients were divided into two risk subgroups and the survival outcomes were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The 5-year OS and DFS were 76.7% and 86.1% (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.002), 68.7% and 78.3% (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.0016) for the &lt; 5 and \u2265 5 cycles, respectively. In subgroup analysis, the survival benefit of \u2265 5 cycles could be maintained in patients with &gt; 50 years old, squamous disease, squamous cell carcinoma antigen (SCC Ag) &gt; 1.5 ng\/mL, tumor size &gt; 4 cm, International Federation of Gynecology and Obstetrics (FIGO) stage I\/II, and no para-aortic metastatic lymph nodes, whereas no significant benefit was observed in FIGO stage III\/IV. A nomogram incorporating size, SCC Ag, and stage was constructed, and patients were divided into two risk groups (low-risk and high-risk). Receiving \u2265 5 cycles showed superiority in OS (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.0025) and DFS (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.008) over &lt; 5 cycles in the low-risk subgroup.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Receiving \u2265 5 cycles of cisplatin was associated with OS and DFS in patients with CC who received CCRT. A nomogram was constructed and the newly defined low-risk patients might gain significant OS and DFS benefit from receiving \u2265 5 cycles\n                      <jats:bold>.<\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15330338261446498","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T06:56:58Z","timestamp":1776841018000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Cisplatin Cycles on Prognosis for Cervical Cancer Patients Treated With Concurrent Chemoradiotherapy: A Retrospective Cohort Study"],"prefix":"10.1177","volume":"25","author":[{"given":"Zheng","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xilin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoliang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2624-9869","authenticated-orcid":false,"given":"Junfang","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1079-5137","authenticated-orcid":false,"given":"Ke","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuquan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21820"},{"key":"e_1_3_6_3_2","volume-title":"NCCN Clinical Practice Guidelines in Oncology:Cervical Cancer","author":"Network NCC","year":"2024","unstructured":"Network NCC. NCCN Clinical Practice Guidelines in Oncology:Cervical Cancer. National Comprehensive Cancer Network; 2024. Version 2."},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199904153401501"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199904153401502"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.5179"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01808-7"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2025.06.003"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0000000000001079"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2017.141"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01438-7"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14102449"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2022.100565"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2023-004429"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prro.2020.04.002"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2019.7289"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-023-03151-3"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol31050188"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12067"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70155-X"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0000000000000507"},{"key":"e_1_3_6_23_2","volume-title":"Cervical Cancer: A Comprehensive Guide","author":"Smith JA","year":"2020","unstructured":"Smith JA, Robert BD. Cervical Cancer: A Comprehensive Guide. Medical Publishing House; 2020."},{"key":"e_1_3_6_24_2","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2024.35.e10"},{"key":"e_1_3_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.05.028"},{"key":"e_1_3_6_26_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.02769"},{"key":"e_1_3_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2013.01.037"},{"key":"e_1_3_6_28_2","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2022-003766"},{"key":"e_1_3_6_29_2","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2024-005419"},{"key":"e_1_3_6_30_2","doi-asserted-by":"publisher","DOI":"10.5603\/RPOR.a2023.0031"},{"key":"e_1_3_6_31_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics14010005"},{"key":"e_1_3_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2019.09.003"},{"key":"e_1_3_6_33_2","doi-asserted-by":"publisher","DOI":"10.1177\/17588359231165974"},{"key":"e_1_3_6_34_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-019-1355-4"},{"key":"e_1_3_6_35_2","doi-asserted-by":"publisher","DOI":"10.1177\/15330338211044626"},{"key":"e_1_3_6_36_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-024-12358-8"},{"key":"e_1_3_6_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.currproblcancer.2018.01.016"},{"key":"e_1_3_6_38_2","doi-asserted-by":"publisher","DOI":"10.17305\/bjbms.2022.7859"},{"key":"e_1_3_6_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2019.04.013"},{"key":"e_1_3_6_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(23)00147-X"},{"key":"e_1_3_6_41_2","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2019.30.e82"},{"key":"e_1_3_6_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.06.011"},{"key":"e_1_3_6_43_2","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2018.29.e91"},{"key":"e_1_3_6_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2021.06.002"}],"container-title":["Technology in Cancer Research &amp; Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15330338261446498","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15330338261446498","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15330338261446498","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T06:18:06Z","timestamp":1777702686000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15330338261446498"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":43,"alternative-id":["10.1177\/15330338261446498"],"URL":"https:\/\/doi.org\/10.1177\/15330338261446498","relation":{"has-review":[{"id-type":"doi","id":"10.1177\/15330338261446498\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/15330338261446498\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/15330338261446498\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/15330338261446498\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/15330338261446498\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/15330338261446498\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/15330338261446498\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/15330338261446498\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/15330338261446498\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/15330338261446498\/v3\/decision1","asserted-by":"object"}]},"ISSN":["1533-0346","1533-0338"],"issn-type":[{"value":"1533-0346","type":"print"},{"value":"1533-0338","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"article-number":"15330338261446498"}}