{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T09:14:38Z","timestamp":1783242878452,"version":"3.54.6"},"reference-count":45,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Hubei Province key research and development project","award":["2022BCA016; 2023BCB146"],"award-info":[{"award-number":["2022BCA016; 2023BCB146"]}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People\u2019s Republic of China","doi-asserted-by":"crossref","award":["2022YFF1203300"],"award-info":[{"award-number":["2022YFF1203300"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National NaturalScience Foundation of China","award":["No.82270110"],"award-info":[{"award-number":["No.82270110"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technol Cancer Res Treat"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Clinical prediction models for response to epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) therapy in patients with advanced non-small cell lung cancer (NSCLC) with bone metastasis (BoM) and EGFR mutations are lacking. This study evaluated predictors of response to the EGFR-TKI icotinib in patients with NSCLC and BoM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analysed patients with EGFR-mutated NSCLC and BoM treated with icotinib at Wuhan Union Hospital. Least absolute shrinkage and selection operator and multivariate Cox regression analyses identified independent predictors of progression-free survival (PFS). A prognostic nomogram was developed, and its effectiveness was assessed using receiver operating characteristic (ROC) curves, a decision curve analysis (DCA), and calibration curves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 194 patients (106 with and 88 without BoM), median PFS in the BoM group was 9.8 months, with a 35.8% overall response rate, and 66.0% disease control rate. In univariate and multivariate Cox regression analyses, BoM was an independent predictor of PFS in the overall cohort (hazard ratio [HR], 2.12; 95% confidence interval [CI], 1.34\u20133.07; P &lt; 0.001). In the BoM subgroup, albumin (HR: 0.36; 95% CI: 0.21\u20130.62; P &lt; 0.001), lactate dehydrogenase (LDH) (HR: 1.99; 95% CI: 1.21\u20133.28; P = 0.007), and the platelet\u2013lymphocyte ratio (PLR) (HR: 1.85; 95% CI: 1.05\u20133.25; P = 0.033) were independently associated with PFS. A nomogram predicting 3-, 6-, and 12-month PFS achieved time-dependent areas under the ROC curve of 0.765, 0.743, and 0.724, respectively. Calibration plots and DCA demonstrated acceptable performance and potential clinical relevance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Albumin, LDH, and PLR predict PFS in EGFR-mutated NSCLC with BoM treated with icotinib. The proposed nomogram may assist in preliminary risk stratification in this specific population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15330338261456855","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T08:46:16Z","timestamp":1783068376000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Survival Prediction in Patients With Epidermal Growth Factor Receptor-Mutated Non-small Cell Lung Cancer With Bone Metastases Receiving Icotinib Therapy: A Retrospective Observational Study"],"prefix":"10.1177","volume":"25","author":[{"given":"Yanling","family":"Ma","sequence":"first","affiliation":[{"name":"Tongji Medical College, Huazhong University of Science and Technology"},{"name":"Tongji Medical College, Huazhong University of Science and Technology"},{"name":"Tongji Medical College"},{"name":"Huazhong University of Science and 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