{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:53:10Z","timestamp":1781484790046,"version":"3.54.1"},"reference-count":67,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Qingdao University Clinical+X-plan Project","award":["QDFY+X2023104"],"award-info":[{"award-number":["QDFY+X2023104"]}]},{"name":"Qingdao Medical and Health Excellent Youth Talent Training Project"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technol Cancer Res Treat"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>This retrospective case series evaluated the feasibility, safety, and potential clinical role of high-intensity focused ultrasound (HIFU) as local consolidative therapy (LCT) in patients with initially unresectable colorectal liver metastases (CRLM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed five patients with CRLM between 2019-2023 who underwent HIFU ablation in addition to systemic chemotherapy. Tumor response was assessed by contrast-enhanced MRI using modified Response Evaluation Criteria in Solid Tumors (mRECIST). Adverse events, conversion to resectability, and survival outcomes were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All five patients underwent R0 resection after treatment incorporating systemic chemotherapy, HIFU, and surgery (median HIFU-to-surgery interval 383 days; range 17\u20131361 days), suggesting potential utility of HIFU both as immediate consolidation and as a long-term bridge-to-resection therapy. Only mild, self-limiting adverse events (transient liver enzyme (AST\/ALT) elevation and local edema) were observed; no severe complications occurred. Median overall survival (OS) from diagnosis of liver metastases was 63.8 months, with 1-, 2-, 3-, and 5-year OS rates of 100%, 100%, 80%, and 60%, respectively. Median OS from the date of first HIFU treatment was 51.4 months (1-, 2-, 3-, and 5-year rates: 100%, 100%, 80%, and 60%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HIFU appears to be a safe local ablative technique and may be integrated into multimodal management of initially unresectable CRLM, and may support conversion to curative-intent resection with encouraging survival outcomes in this small series. Larger prospective studies are warranted to validate these findings and define optimal patient selection and treatment sequencing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15330338261461451","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T12:39:36Z","timestamp":1781181576000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The Role of High-Intensity Focused Ultrasound as a Local Consolidative Therapy in Multimodal Conversion Treatment for Colorectal Liver Metastases: A Case Series"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7045-7273","authenticated-orcid":false,"given":"Guangtan","family":"Du","sequence":"first","affiliation":[{"name":"Affiliated Hospital of Qingdao University"},{"name":"Qingdao 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