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This study addresses the gap by comparing two mainstream radiotherapy systems for non-coplanar VMAT (NCVMAT) with flattening filter-free (FFF) and flattened (FF) beams.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective dosimetric cohort study was conducted on 22 consecutive patients. Four plan types were created: MC-NCVMAT (Elekta Infinity\/Monaco) FFF\/FF and UT-NCVMAT (UIH uRT-linac 506c\/uRT-TPOIS) FFF\/FF. Dosimetry, organ-at-risk (OAR) sparing, efficiency, and plan quality metric (PQM) were evaluated. Identical constraints were applied across platforms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>UT-NCVMAT showed significantly better homogeneity, conformity, and OAR sparing than MC-NCVMAT. FFF beams outperformed FF in hippocampal protection. UT-NCVMAT reduced beam-on time and planning time by 44%. The 16-item PQM score was significantly higher in the UIH group. Post-hoc power analysis confirmed sample adequacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The UIH uRT-TPOIS system with NCVMAT FFF may offer superior dosimetry, efficiency, and clinical feasibility for HA-WBRT. The PQM model may serve as a reliable tool for standardized plan evaluation. Further multi-center validation is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15330338261467841","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T06:06:27Z","timestamp":1783749987000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A Comprehensive Dosimetric and Plan Quality Evaluation of Non-coplanar VMAT With Flattening Filter-free Versus Flattened Beams for Hippocampal-Avoidance Whole-Brain Radiotherapy: A Multi-Platform Study on Elekta Infinity and UIH uRT-Linac Systems"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4219-2172","authenticated-orcid":false,"given":"Xiao-long","family":"Cheng","sequence":"first","affiliation":[{"name":"Zhejiang Cancer Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[{"name":"The First People\u2019s Hospital of Aksu Prefecture"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Sun","sequence":"additional","affiliation":[{"name":"Zhejiang Cancer Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-liang","family":"Yu","sequence":"additional","affiliation":[{"name":"Quzhou City People\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.75.9589"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.00011"},{"key":"e_1_3_7_4_2","first-page":"301","article-title":"Hippocampal sparing in brain radiotherapy","volume":"66","author":"Konopka FM","year":"2016","unstructured":"Konopka FM, Sierko E, Wojtukiewicz MZ. 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