{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T09:07:00Z","timestamp":1789117620622,"version":"build-2803163510"},"reference-count":25,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004377","name":"Hong Kong Polytechnic University","doi-asserted-by":"publisher","award":["P0048845"],"award-info":[{"award-number":["P0048845"]}],"id":[{"id":"10.13039\/501100004377","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004377","name":"Hong Kong Polytechnic University","doi-asserted-by":"publisher","award":["P0056738"],"award-info":[{"award-number":["P0056738"]}],"id":[{"id":"10.13039\/501100004377","id-type":"DOI","asserted-by":"publisher"}]},{"name":"General Research Fund of Research Grants Council","award":["15102524"],"award-info":[{"award-number":["15102524"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technol Cancer Res Treat"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The influence of ultrasound imaging plane on the diagnostic performance of artificial intelligence-based computer-aided diagnosis systems for thyroid nodules remains unclear. This study evaluated S-Detect in transverse and longitudinal ultrasound planes and compared four plane-based interpretation strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective cross-sectional study included 157 patients with 207 surgically confirmed thyroid nodules. Each nodule was independently analyzed by S-Detect in transverse (S-Detect_T) and longitudinal (S-Detect_L) planes. Four diagnostic strategies were evaluated: transverse-plane assessment, longitudinal-plane assessment, a serial strategy classifying a nodule as possibly malignant only when both planes indicated possible malignancy, and a parallel strategy classifying a nodule as possibly malignant when either plane indicated possible malignancy. Diagnostic performance, agreement, and interplane discordance were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 207 nodules, 140 were malignant and 67 were benign. S-Detect_L showed numerically higher sensitivity and specificity than S-Detect_T (93.6% vs 92.1% and 62.7% vs 59.7%, respectively), but neither difference was statistically significant. Transverse- and longitudinal-plane classifications agreed in 89.4% of nodules, whereas 10.6% showed interplane discordance. The parallel strategy achieved the highest sensitivity (97.9%) and negative predictive value (92.5%) but the lowest specificity (55.2%). The serial strategy achieved the highest specificity (67.2%) and the lowest false-positive rate (32.8%) but had lower sensitivity (87.9%). Compared with the serial strategy, the parallel strategy identified 14 additional malignant nodules while producing eight additional false-positive classifications. A sensitivity analysis restricted to one nodule per patient showed the same overall pattern.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Transverse- and longitudinal-plane S-Detect assessments showed similar diagnostic performance, although interplane discordance occurred in a subset of nodules. The parallel strategy favored sensitivity, whereas the serial strategy favored specificity and fewer false-positive classifications. No imaging plane or combination rule was consistently superior across all diagnostic measures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15330338261489053","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:32:06Z","timestamp":1788870726000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating Diagnostic Strategies for Thyroid Nodule Assessment Using S-Detect in Transverse and Longitudinal Ultrasound Planes"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2765-5002","authenticated-orcid":false,"given":"Ziman","family":"Chen","sequence":"first","affiliation":[{"name":"The Hong Kong Polytechnic University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengting","family":"Ye","sequence":"additional","affiliation":[{"name":"The Fifth Affiliated Hospital of Sun Yat-sen University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieyi","family":"Liang","sequence":"additional","affiliation":[{"name":"The Fifth Affiliated Hospital of Sun Yat-sen University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Chen","sequence":"additional","affiliation":[{"name":"The Fifth Affiliated Hospital of Sun Yat-sen University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Tin Cheung","family":"Ying","sequence":"additional","affiliation":[{"name":"The Hong Kong Polytechnic University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12081676"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16020311"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacr.2017.01.046"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0020"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2020.0578"},{"key":"e_1_3_8_7_2","doi-asserted-by":"publisher","DOI":"10.1530\/ETJ-23-0067"},{"key":"e_1_3_8_8_2","doi-asserted-by":"publisher","DOI":"10.1530\/ETJ-22-0134"},{"key":"e_1_3_8_9_2","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2003.22.10.1027"},{"key":"e_1_3_8_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-025-13917-3"},{"key":"e_1_3_8_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-025-11386-7"},{"key":"e_1_3_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2024.02.013"},{"key":"e_1_3_8_13_2","doi-asserted-by":"publisher","DOI":"10.2147\/JMDH.S439629"},{"key":"e_1_3_8_14_2","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgae277"},{"key":"e_1_3_8_15_2","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2018.19.4.665"},{"key":"e_1_3_8_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-022-09378-y"},{"key":"e_1_3_8_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1098031"},{"key":"e_1_3_8_18_2","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S348463"},{"key":"e_1_3_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2024.08.005"},{"key":"e_1_3_8_20_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.909277"},{"key":"e_1_3_8_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39335.541782.AD"},{"key":"e_1_3_8_22_2","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.931957"},{"key":"e_1_3_8_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10278-016-9929-2"},{"key":"e_1_3_8_24_2","doi-asserted-by":"publisher","DOI":"10.1109\/JPROC.2021.3054390"},{"key":"e_1_3_8_25_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1137700"},{"key":"e_1_3_8_26_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2010.0372"}],"container-title":["Technology in Cancer Research &amp; Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15330338261489053","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15330338261489053","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15330338261489053","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T08:18:06Z","timestamp":1789114686000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15330338261489053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":25,"alternative-id":["10.1177\/15330338261489053"],"URL":"https:\/\/doi.org\/10.1177\/15330338261489053","relation":{},"ISSN":["1533-0346","1533-0338"],"issn-type":[{"value":"1533-0346","type":"print"},{"value":"1533-0338","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"article-number":"15330338261489053"}}