{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:55:39Z","timestamp":1790942139123,"version":"4.1.0"},"reference-count":25,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Shanghai Pudong New Area Peak and Plateau Discipline Development Program for Clinical Medicine Innovative Specialty","award":["(2025-PWXZ-11)"],"award-info":[{"award-number":["(2025-PWXZ-11)"]}]},{"name":"The Scientific Research Project of Shanghai Municipal Health Commission","award":["(202340056)"],"award-info":[{"award-number":["(202340056)"]}]},{"name":"The Discipline Construction Project of Pudong New Area Health Commission, Shanghai","award":["(PWZxk2022-09)"],"award-info":[{"award-number":["(PWZxk2022-09)"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technol Cancer Res Treat"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Cell membrane\u2013coated nanoparticles are emerging as promising biomimetic platforms for targeted cancer drug delivery, owing to their homotypic tumor-targeting ability and favorable biocompatibility. In this study, we fabricated a biomimetic DOX@Mem-HMnO\n                      <jats:sub>2<\/jats:sub>\n                      nanosystem based on hollow mesoporous manganese dioxide (HMnO\n                      <jats:sub>2<\/jats:sub>\n                      ) coated with A549 lung adenocarcinoma cell membrane (Mem) and loaded with doxorubicin (DOX), and evaluated its in vitro biological performance using the A549 cell model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Monodisperse silica nanoparticles were synthesized via a modified St\u00f6ber method as sacrificial templates to prepare hollow mesoporous HMnO\n                      <jats:sub>2<\/jats:sub>\n                      . DOX was loaded into HMnO\n                      <jats:sub>2<\/jats:sub>\n                      , and native A549 cell membrane was isolated by differential centrifugation and wrapped onto DOX-loaded HMnO\n                      <jats:sub>2<\/jats:sub>\n                      . SEM and TEM characterized morphology and membrane coating; UV-Vis spectrophotometry confirmed DOX loading; particle size and zeta potential were measured, and colloidal stability was monitored over 72 h in deionized water and DMEM. CCK-8 and Transwell assays evaluated anti-proliferative and anti-migratory effects (\u22653 independent replicates).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      DOX@Mem-HMnO\n                      <jats:sub>2<\/jats:sub>\n                      was successfully prepared as spherical, relatively monodisperse nanoparticles with an observable membrane-like outer layer and retained DOX characteristic absorbance. Zeta potential shifted from \u221242.1 \u00b1 1.8 mV (bare HMnO\n                      <jats:sub>2<\/jats:sub>\n                      ) to \u221223.8 \u00b1 1.5 mV after membrane coating and \u221230.2 \u00b1 1.6 mV after DOX loading. The nanosystem remained stable without aggregation over 72 h. All DOX-containing groups inhibited A549 proliferation in a concentration-dependent manner; DOX@Mem-HMnO\n                      <jats:sub>2<\/jats:sub>\n                      produced significantly stronger anti-proliferative and anti-migratory effects than free DOX and DOX@HMnO\n                      <jats:sub>2<\/jats:sub>\n                      (P &lt; 0.05), while empty carriers showed low intrinsic cytotoxicity. This study is limited to in vitro A549 experiments; direct evidence for homotypic targeting and in vivo performance is absent.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      DOX@Mem-HMnO\n                      <jats:sub>2<\/jats:sub>\n                      can be readily synthesized with uniform morphology, favorable colloidal stability, and enhanced in vitro anti-proliferative and anti-migratory activity against A549 cells, providing a proof-of-concept basis for further biological validation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15330338261494055","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:24:06Z","timestamp":1790717046000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Preparation and In Vitro Evaluation of the DOX@Mem-HMnO2 Bioinspired Nanosystem: A Proof-of-Concept Study"],"prefix":"10.1177","volume":"25","author":[{"given":"Jiangang","family":"Chen","sequence":"first","affiliation":[{"name":"Ningxia Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ao","family":"Xu","sequence":"additional","affiliation":[{"name":"Ningxia Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusheng","family":"Tang","sequence":"additional","affiliation":[{"name":"Ningxia Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Yang","sequence":"additional","affiliation":[{"name":"Shanghai University of Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shibo","family":"Gao","sequence":"additional","affiliation":[{"name":"Shanghai University of Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8903-7966","authenticated-orcid":false,"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Gongli Hospital Pudong New Area"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26072945"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202414100"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.121977"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02167-1"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202106511"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2026.123993"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2025.139170"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2026.115505"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2025.115088"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2025.114759"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2023.102888"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jncc.2023.08.004"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2025.108531"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.iecr.5c01564"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rineng.2026.109819"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2009.12.016"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2015.11.033"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.inoche.2004.11.004"},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcc.8b02617"},{"key":"e_1_3_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2020.102321"},{"key":"e_1_3_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jallcom.2019.153186"},{"key":"e_1_3_7_23_2","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2022.2149897"},{"key":"e_1_3_7_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202503057"},{"key":"e_1_3_7_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02301-z"},{"key":"e_1_3_7_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202407245"}],"container-title":["Technology in Cancer Research &amp; 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