{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:36:18Z","timestamp":1792787778939,"version":"4.5.0"},"reference-count":34,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Shanghai Songjiang District Key Medical Discipline Construction Project","award":["24SJYYZDA03"],"award-info":[{"award-number":["24SJYYZDA03"]}]},{"name":"Songjiang Hospital Affiliated to Shanghai Jiaotong University School of Medicine","id":[{"id":"https:\/\/ror.org\/0220qvk04","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technol Cancer Res Treat"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Visceral fat is associated with cancer risk. Intrapancreatic fat deposition (IPFD) has been associated with pancreatic diseases, but its role in extra-pancreatic malignancies remains unclear. This case-control study aimed to investigate the association between IPFD and prostate cancer risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 143 patients with newly diagnosed, treatment-na\u00efve prostate cancer and 286 age-matched controls without malignancy were enrolled in this retrospective study. IPFD was assessed using unenhanced computed tomography (CT) by two markers: pancreatic CT attenuation (PanCT) and pancreatic-to-spleen attenuation ratio (P\/S). Multivariable logistic regression was performed to evaluate the association between IPFD and prostate cancer risk, with sequential adjustment for demographic, metabolic, and hepatic parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The risk of prostate cancer decreases as PanCT (p &lt; 0.01) and P\/S increases (p = 0.05). Participants with prostate cancer had lower pancreatic CT attenuation compared to controls. In fully adjusted models, higher PanCT quartiles were associated with progressively lower odds of prostate cancer (Q2: OR 0.32, 95% CI 0.15\u20130.69; Q3: OR 0.21, 95% CI 0.08\u20130.52; Q4: OR 0.11, 95% CI 0.04\u20130.29; all p &lt; 0.01). Similar inverse associations were observed for P\/S ratio quartiles (Q3: OR 0.30, 95% CI 0.13\u20130.68; Q4: OR 0.31, 95% CI 0.13\u20130.75).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Intrapancreatic fat deposition is independently associated with an increased risk of prostate cancer, regardless of hepatic fat and body mass index.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15330338261500542","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:21:14Z","timestamp":1792110074000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Intrapancreatic Fat Deposition and Prostate Cancer Risk: A Primary Case-Control Study"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4072-1191","authenticated-orcid":false,"given":"Hui","family":"Wang","sequence":"first","affiliation":[{"name":"Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6171-1078","authenticated-orcid":false,"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0497-7961","authenticated-orcid":false,"given":"Kui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of 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