{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:36:01Z","timestamp":1777941361269,"version":"3.51.4"},"reference-count":44,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"},{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technol Cancer Res Treat"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p>\n                    We treat prostate and seminal vesicles (SV) to 45 Gy in 25 fractions (course 1) and boost prostate to 81 Gy in 20 more fractions (course 2) with Intensity Modulated Radiation Therapy (IMRT). This two-course IMRT with 45 fractions delivered a non-uniform dose to SV and required two plans and two QA procedures. We used Linear Quadratic (LQ) model to develop a single course IMRT plan to treat SV to a uniform dose, which has the same biological effective dose (BED) as that of 45 Gy in 25 fractions and prostate to 81 Gy, in 45 fractions. Single course IMRT plans were compared with two-course IMRT plans, retrospectively for 14 patients. With two-course IMRT, prescription to prostate and SV was 45 Gy in 25 fractions and to prostate only was 36 Gy in 20 fractions, at 1.8 Gy\/fraction. With 45-fraction single course IMRT plan, prescription to prostate was 81 Gy and to SV was 52 or 56 Gy for a \u03b1\/\u03b2 of 1 and 3, respectively. 52 Gy delivered in 45 fractions has the same BED of 72 Gy\n                    <jats:sub>3<\/jats:sub>\n                    as that of delivering 45 Gy in 25 fractions, and is called Matched Effective Dose (MED). LQ model was used to calculate the BED and MED to SV for \u03b1\/\u03b2 values of 1\u201310. Comparison between two-course and single course IMRT plans was in terms of MUs, dose-max, and dose volume constraints (DVC). DVC were: 95% PTV to be covered by at least 95% of prescription dose; and 70, 50, and 30% of bladder and rectum should not receive more than 40, 60, and 70% of 81 Gy. SV Volumes ranged from 2.9\u201330 cc. With two-course IMRT plans, mean dose to SV was non-uniform and varied between patients by 48% (54 to 80 Gy). With single-course IMRT plan, mean dose to SV was more uniform and varied between patients by only 9.6% (58.2 to 63.8 Gy), to deliver MED of 56 Gy for \u03b1\/\u03b2 \u2212 1. Single course IMRT plan MUs were slightly larger than those for two-course IMRT plans, but within the range seen for two-course plans (549\u2013959 MUs, n=51). Dose max for single-course plans were similar to two-course plans. Doses to PTV, rectum and bladder with single course plans were as per DVC and comparable to two-course plans. Single course IMRT plan reduces IMRT planning and QA time to half.\n                  <\/jats:p>","DOI":"10.1177\/153303460600500507","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:55:00Z","timestamp":1412348100000},"page":"503-511","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Single Course IMRT Plan to Deliver 45 Gy to Seminal Vesicles and 81 Gy to Prostate in 45 Fractions"],"prefix":"10.1177","volume":"5","author":[{"given":"Nandanuri M. S.","family":"Reddy","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology The New York Hospital Queens 56-45 Main Street Flushing, NY 11355, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brij Mohan","family":"Sood","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The New York Hospital Queens 56-45 Main Street Flushing, NY 11355, USA"},{"name":"Department of Radiation Oncology New York Presbyterian Hospital Weill-Cornell Medical Center 525 East 68th Street New York, NY 10021, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seshadri","family":"Sampath","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The New York Hospital Queens 56-45 Main Street Flushing, NY 11355, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrej","family":"Mazur","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The New York Hospital Queens 56-45 Main Street Flushing, NY 11355, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Osian","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The New York Hospital Queens 56-45 Main Street Flushing, NY 11355, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akkamma","family":"Ravi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The New York Hospital Queens 56-45 Main Street Flushing, NY 11355, USA"},{"name":"Department of Radiation Oncology New York Presbyterian Hospital Weill-Cornell Medical Center 525 East 68th Street New York, NY 10021, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaganmohan","family":"Poli","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The New York Hospital Queens 56-45 Main Street Flushing, NY 11355, USA"},{"name":"Department of Radiation Oncology New York Presbyterian Hospital Weill-Cornell Medical Center 525 East 68th Street New York, NY 10021, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dattatreyudu","family":"Nori","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The New York Hospital Queens 56-45 Main Street Flushing, NY 11355, USA"},{"name":"Department of Radiation Oncology New York Presbyterian Hospital Weill-Cornell Medical Center 525 East 68th Street New York, NY 10021, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2006,10,1]]},"reference":[{"key":"bibr1-153303460600500507","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.05.054"},{"key":"bibr2-153303460600500507","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(97)00458-6"},{"key":"bibr3-153303460600500507","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(99)00304-1"},{"key":"bibr4-153303460600500507","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(99)00438-1"},{"key":"bibr5-153303460600500507","doi-asserted-by":"publisher","DOI":"10.1120\/jacmp.v2i2.2614"},{"key":"bibr6-153303460600500507","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(03)01569-4"},{"key":"bibr7-153303460600500507","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.04.007"},{"key":"bibr8-153303460600500507","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(99)00101-7"},{"key":"bibr9-153303460600500507","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.11.034"},{"key":"bibr10-153303460600500507","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(99)00454-X"},{"key":"bibr11-153303460600500507","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(01)02676-1"},{"key":"bibr12-153303460600500507","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/66104316"},{"key":"bibr13-153303460600500507","doi-asserted-by":"publisher","DOI":"10.1120\/jacmp.v3i4.2551"},{"key":"bibr14-153303460600500507","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(04)01893-0"},{"key":"bibr15-153303460600500507","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(82)90459-X"},{"key":"bibr16-153303460600500507","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2003.12.031"},{"key":"bibr17-153303460600500507","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(01)01650-9"},{"key":"bibr18-153303460600500507","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(02)03051-1"},{"key":"bibr19-153303460600500507","first-page":"211","volume-title":"Radiobiology for the Radiologist","author":"Hall E. 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An Evaluation of Pd-103 Versus I-125 Based on Radiobiological Effectiveness and Dosimetry."},{"key":"bibr32-153303460600500507","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(03)01456-1"},{"key":"bibr33-153303460600500507","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(96)00617-7"},{"key":"bibr34-153303460600500507","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(00)00640-3"},{"key":"bibr35-153303460600500507","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(00)00793-8"},{"key":"bibr36-153303460600500507","doi-asserted-by":"publisher","DOI":"10.1177\/153303460400300403"},{"key":"bibr37-153303460600500507","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2003.12.028"},{"key":"bibr38-153303460600500507","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.01.042"},{"key":"bibr39-153303460600500507","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(02)02901-2"},{"key":"bibr40-153303460600500507","volume-title":"Fractionation in Radiotherapy.","author":"Thames H. 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