{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:25:26Z","timestamp":1792074326357,"version":"4.4.0"},"reference-count":12,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Technol Cancer Res Treat"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:p>Single-photon emission computed tomography (SPECT) can provide specific functional information while magnetic resonance imaging (MRI) can provide high-spatial resolution anatomical information as well as complementary functional information. In this study, we utilized a dual modality SPECT\/MRI (MRSPECT) system to investigate the integration of SPECT and MRI for improved image accuracy. The MRSPECT system consisted of a cadmiumzinc-telluride (CZT) nuclear radiation detector interfaced with a specialized radiofrequency (RF) coil that was placed within a whole-body 4 T MRI system. The importance of proper corrections for non-uniform detector sensitivity and Lorentz force effects was demonstrated. MRI data were utilized for attenuation correction (AC) of the nuclear projection data and optimized Wiener filtering of the SPECT reconstruction for improved image accuracy. Finally, simultaneous dual-imaging of a nude mouse was performed to demonstrated the utility of co-registration for accurate localization of a radioactive source.<\/jats:p>","DOI":"10.1177\/153303461000900103","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:55:00Z","timestamp":1412348100000},"page":"21-27","source":"Crossref","is-referenced-by-count":17,"title":["Initial Investigation of Preclinical Integrated SPECT and MR Imaging"],"prefix":"10.1177","volume":"9","author":[{"given":"Mark J.","family":"Hamamura","sequence":"first","affiliation":[{"name":"Tu & Yuen Center for Functional Onco-Imaging, University of California, 164 Irvine Hall Irvine, CA 92697-5020 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seunghoon","family":"Ha","sequence":"additional","affiliation":[{"name":"Tu & Yuen Center for Functional Onco-Imaging, University of California, 164 Irvine Hall Irvine, CA 92697-5020 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner W.","family":"Roeck","sequence":"additional","affiliation":[{"name":"Tu & Yuen Center for Functional Onco-Imaging, University of California, 164 Irvine Hall Irvine, CA 92697-5020 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas J.","family":"Wagenaar","sequence":"additional","affiliation":[{"name":"Gamma Medica-Ideas, Inc. 19355 Business Center Drive, Suite 8 Northridge, CA 91324 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Meier","sequence":"additional","affiliation":[{"name":"Gamma Medica-Ideas, Inc. 19355 Business Center Drive, Suite 8 Northridge, CA 91324 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley E.","family":"Patt","sequence":"additional","affiliation":[{"name":"Gamma Medica-Ideas, Inc. 19355 Business Center Drive, Suite 8 Northridge, CA 91324 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orhan","family":"Nalcioglu","sequence":"additional","affiliation":[{"name":"Tu & Yuen Center for Functional Onco-Imaging, University of California, 164 Irvine Hall Irvine, CA 92697-5020 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,2,1]]},"reference":[{"key":"bibr1-153303461000900103","doi-asserted-by":"publisher","DOI":"10.1177\/153303460600500406"},{"key":"bibr2-153303461000900103","doi-asserted-by":"publisher","DOI":"10.1016\/j.nima.2006.10.131"},{"key":"bibr3-153303461000900103","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.107.044313"},{"key":"bibr4-153303461000900103","doi-asserted-by":"crossref","unstructured":"Meng L. J., Tan J. W., Geng F. Design Study of an MRI Compatible Ultra-high Resolution SPECT for\n                      In Vivo\n                      Mice Brain Imaging.\n                      IEEE 2007 Nuc Sci Sym Conference Record\n                      , 2956\u20132960 (2007).","DOI":"10.1109\/NSSMIC.2007.4436754"},{"key":"bibr5-153303461000900103","unstructured":"Hamamura M. J., Ha S., Roeck W. W., Muftuler L. T., Wagenaar D. J., Meier D., Patt B. E., Nalcioglu O. Development of an MR-compatible SPECT System (MRSPECT) for Simultaneous Data Acquisition.\n                      Phys Med Biol\n                      (submitted)."},{"key":"bibr6-153303461000900103","doi-asserted-by":"crossref","unstructured":"Wagenaar D., Nalcioglu O., Muftuler L., Szawlowski M., Kapusta M., Pawlov N., Meier D., Maehlum G., Patt B. Development of MRI-compatible Nuclear Medicine Imaging Detectors.\n                      IEEE 2006 Nuc Sci Sym Conference Record\n                      , 1825\u20131828 (2006).","DOI":"10.1109\/NSSMIC.2006.354248"},{"key":"bibr7-153303461000900103","unstructured":"Nalcioglu O., Roeck W. W., Ha S-H. Multi-modality RF Coil. USA patent pending (2008)."},{"key":"bibr8-153303461000900103","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910340616"},{"key":"bibr9-153303461000900103","doi-asserted-by":"publisher","DOI":"10.1177\/153303460600500402"},{"key":"bibr10-153303461000900103","doi-asserted-by":"publisher","DOI":"10.1109\/TNS.1978.4329385"},{"key":"bibr11-153303461000900103","doi-asserted-by":"publisher","DOI":"10.1063\/1.3120522"},{"key":"bibr12-153303461000900103","unstructured":"Ha S., Hamamura M. J., Roeck W. W., Muftuler L. T., Nalcioglu O. Development of a New RF Coil and \u03b3-ray Radiation Shielding Assembly for a SPECT\/MRI System.\n                      Phys Med Biol\n                      (submitted)."}],"container-title":["Technology in Cancer Research &amp; Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/153303461000900103","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/153303461000900103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T06:23:14Z","timestamp":1777702994000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/153303461000900103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["10.1177\/153303461000900103"],"URL":"https:\/\/doi.org\/10.1177\/153303461000900103","relation":{},"ISSN":["1533-0346","1533-0338"],"issn-type":[{"value":"1533-0346","type":"print"},{"value":"1533-0338","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2]]}}}