{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T07:46:59Z","timestamp":1778658419344,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T00:00:00Z","timestamp":1429833600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technol Cancer Res Treat"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:p>Lung cancer is a common malignant tumor with high morbidity and mortality. Here we compared the effects and outcome between central and peripheral stage I lung cancer using image-guided stereotactic body radiotherapy. From June 2011 to July 2013, a total of 33 patients with stage I lung cancer were enrolled. A total of 50 Gy in 10 fractions or 60 Gy in 10 fractions was delivered in the central arm (n = 18), while 50 Gy in 5 fractions in the peripheral arm (n = 15). Statistical analyses were performed using logistic regression analysis and Kaplan-Meier method. The mean follow-up time was 38.1 months. Three-month, 1-, 2-, and 3-year overall response rates were 66.7%, 83.3%, 61.1%, and 72.2% and 66.7%, 80%, 80%, and 80% in the central and peripheral arms, respectively. Three-year local control rates (94.4% vs 93.3%, P = .854), regional control rates (94.4% vs 86.7%, P = .412), and distant control rates (64.2% vs 61.7%, P = .509) had no differences between the central and the peripheral arms. Grade 2 radiation pneumonitis was observed in 6 of 18 patients in the central arm and in 1 of 15 patients in the peripheral arm ( P = .92). Grade 2 radiation esophagitis was 5.7% in the central arm, while none occurred in the peripheral arm ( P = .008). Five (15.1%) of all patients felt slight fatigue during radiotherapy. Other major complications were not observed. In conclusion, helical image-guided stereotactic body radiotherapy for central stage I lung cancer is safe and effective compared to peripheral stage I lung cancer.<\/jats:p>","DOI":"10.1177\/1533034615583206","type":"journal-article","created":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T22:31:24Z","timestamp":1429914684000},"page":"701-707","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Comparison of Effects Between Central and Peripheral Stage I Lung Cancer Using Image-Guided Stereotactic Body Radiotherapy via Helical Tomotherapy"],"prefix":"10.1177","volume":"14","author":[{"given":"Jian","family":"He","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiming","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaochong","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,4,24]]},"reference":[{"issue":"1","key":"bibr1-1533034615583206","first-page":"4","volume":"15","author":"Rami-Porta R","year":"2009","journal-title":"Ann Thorac Cardiovasc Surg"},{"key":"bibr2-1533034615583206","doi-asserted-by":"publisher","DOI":"10.1378\/chest.121.4.1155"},{"key":"bibr3-1533034615583206","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.03.005"},{"key":"bibr4-1533034615583206","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.07.1751"},{"key":"bibr5-1533034615583206","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24759"},{"key":"bibr6-1533034615583206","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-010-2072-y"},{"key":"bibr7-1533034615583206","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2008.06.006"},{"key":"bibr8-1533034615583206","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.02.038"},{"key":"bibr9-1533034615583206","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059729"},{"key":"bibr10-1533034615583206","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.10.059"},{"key":"bibr11-1533034615583206","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059729"},{"key":"bibr12-1533034615583206","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.261"},{"key":"bibr13-1533034615583206","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2011.03.003"},{"key":"bibr14-1533034615583206","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.04.013"},{"key":"bibr15-1533034615583206","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-012-0159-3"},{"key":"bibr16-1533034615583206","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70242-5"},{"key":"bibr17-1533034615583206","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2009.12.008"},{"key":"bibr18-1533034615583206","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.06.2003"},{"key":"bibr19-1533034615583206","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt026"},{"key":"bibr20-1533034615583206","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-0265"},{"key":"bibr21-1533034615583206","doi-asserted-by":"publisher","DOI":"10.1172\/JCI61931"},{"key":"bibr22-1533034615583206","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.09.034"},{"key":"bibr23-1533034615583206","doi-asserted-by":"publisher","DOI":"10.1667\/RR1931.1"},{"key":"bibr24-1533034615583206","doi-asserted-by":"publisher","DOI":"10.1080\/09553000701481816"},{"key":"bibr25-1533034615583206","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/52\/1\/016"},{"key":"bibr26-1533034615583206","doi-asserted-by":"publisher","DOI":"10.1080\/02841860600907329"},{"key":"bibr27-1533034615583206","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2012.06.005"},{"key":"bibr28-1533034615583206","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.11.051"},{"key":"bibr29-1533034615583206","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2013.01.004"}],"container-title":["Technology in Cancer Research &amp; 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