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In this study, we found that miR-155 was upregulated in both uveal melanoma cells and tissues. Transfection of miR-155 mimic into uveal melanoma cells led to an increase in cell growth and invasion; in contrast, inhibition of miR-155 resulted in opposite effects. Also, we identified Nedd4-family interacting protein 1 as a direct target of miR-155, and the expression of Nedd4-family interacting protein 1 was inhibited by miR-155. Furthermore, ectopic expression of Nedd4-family interacting protein 1 restored the effects of miR-155 on cell proliferation and invasion of uveal melanoma cells. In conclusion, miR-155 acts as a tumor promotor in uveal melanoma through increasing cell proliferation and invasion. Thus, miR-155 might serve as a potential therapeutic target in patients with uveal melanoma.<\/jats:p>","DOI":"10.1177\/1533034617737923","type":"journal-article","created":{"date-parts":[[2017,11,2]],"date-time":"2017-11-02T00:08:14Z","timestamp":1509581294000},"page":"1160-1167","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":44,"title":["MiR-155 Promotes Uveal Melanoma Cell Proliferation and Invasion by Regulating NDFIP1 Expression"],"prefix":"10.1177","volume":"16","author":[{"given":"Jing","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Xi\u2019an No. 4 Hospital, Shanxi Ophthalmology Medical Center, Xi\u2019an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Honglei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Xi\u2019an No. 4 Hospital, Shanxi Ophthalmology Medical Center, Xi\u2019an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuihong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Xi\u2019an No. 4 Hospital, Shanxi Ophthalmology Medical Center, Xi\u2019an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,11,1]]},"reference":[{"key":"bibr1-1533034617737923","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2016.05.04"},{"key":"bibr2-1533034617737923","doi-asserted-by":"publisher","DOI":"10.3109\/08820538.2016.1154175"},{"key":"bibr3-1533034617737923","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29727"},{"key":"bibr4-1533034617737923","doi-asserted-by":"publisher","DOI":"10.4274\/tjo.37431"},{"key":"bibr5-1533034617737923","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2016-309034"},{"key":"bibr6-1533034617737923","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2016.08.003"},{"key":"bibr7-1533034617737923","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.10962"},{"key":"bibr8-1533034617737923","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-016-5141-8"},{"key":"bibr9-1533034617737923","doi-asserted-by":"publisher","DOI":"10.1186\/gm516"},{"key":"bibr10-1533034617737923","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2012.04.020"},{"key":"bibr11-1533034617737923","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.3523"},{"key":"bibr12-1533034617737923","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.24.0317"},{"key":"bibr13-1533034617737923","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgp220"},{"key":"bibr14-1533034617737923","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.14320"},{"key":"bibr15-1533034617737923","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.13022"},{"key":"bibr16-1533034617737923","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.06.006"},{"key":"bibr17-1533034617737923","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26157"},{"key":"bibr18-1533034617737923","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11206"},{"key":"bibr19-1533034617737923","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.12155"},{"key":"bibr20-1533034617737923","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2016.2529"},{"key":"bibr21-1533034617737923","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201105009"},{"key":"bibr22-1533034617737923","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjv020"},{"key":"bibr23-1533034617737923","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-016-0101-6"},{"key":"bibr24-1533034617737923","doi-asserted-by":"publisher","DOI":"10.1007\/112_2016_3"},{"key":"bibr25-1533034617737923","doi-asserted-by":"publisher","DOI":"10.3402\/jev.v5.31292"},{"key":"bibr26-1533034617737923","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2016.87"},{"key":"bibr27-1533034617737923","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-013-2230-5"},{"key":"bibr28-1533034617737923","doi-asserted-by":"publisher","DOI":"10.4161\/cc.24987"},{"key":"bibr29-1533034617737923","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-12-0686"},{"key":"bibr30-1533034617737923","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.08.098"},{"key":"bibr31-1533034617737923","doi-asserted-by":"publisher","DOI":"10.1177\/1947601911407325"},{"key":"bibr32-1533034617737923","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.2418"}],"container-title":["Technology in Cancer Research &amp; 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