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The underlying pathology is often considered heterogeneous, but we propose that, in fact, this syndrome has a characteristic underlying neurobiology related to Pick's disease and frontotemporal dementia. The authors reviewed the literature of PPA and found 58 cases with autopsy. The majority of the cases had related underlying pathology, termed \u201cPick complex,\u201d a form of non-Alzheimer's dementia. This includes Pick's disease, corticobasal degeneration, dementia lacking distinctive histology, and motor neuron disease inclusions. Several of the cases described with focal Alzheimer's pathology do not fulfill the criteria of PPA, but have Alzheimer's disease with a major aphasic component.<\/jats:p>","DOI":"10.1177\/153331750201700105","type":"journal-article","created":{"date-parts":[[2006,5,12]],"date-time":"2006-05-12T03:30:46Z","timestamp":1147404646000},"page":"30-36","source":"Crossref","is-referenced-by-count":24,"title":["Primary progressive aphasia: A review of the neourobiology of a common presentation of Pick complex"],"prefix":"10.1177","volume":"17","author":[{"given":"Andrew","family":"Kertesz","sequence":"first","affiliation":[{"name":"Department of Clinical Neurological Sciences, St. Joseph's Health Care, London, Ontario; University of Western Ontario, London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Munoz","sequence":"additional","affiliation":[{"name":"Department of Pathology and Clinical Neurological Sciences, University of Western Ontario, London, Ontario, Canada; Servicio de Neurologia Hospital Universitario \u201cDoce de Octubre,\u201d Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2002,1,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410110607"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410220414"},{"key":"atypb3","first-page":"115","volume":"14","author":"Rosenfeld M","year":"1909","journal-title":"Die partielle Grosshirnatrophie. 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