{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T01:07:50Z","timestamp":1784855270638,"version":"3.55.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Alzheimers Dis Other Demen"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p>Although neuropathologic studies showed that early-onset Alzheimer's disease (EAD) and \u201csenile dementia\u201d were indistinguishable, clinical studies suggested that EAD and late-onset Alzheimer's disease (LAD) were cognitively distinct. We sought to investigate whether EAD and LAD are cognitively different by comparing patients at the extremes of the ages of onset in order to maximize features that might separate them. We compared 44 men with EAD (age of onset less than 65 years) with 44 men with LAD (age of onset 84 years or older) on an intake cognitive screening examination on initial presentation. The EAD and LAD groups did not differ on dementia or most cognitive variables. Compared with EAD, the LAD group had worse verbal fluency and motor-executive functions. These differences disappeared when age differences were taken into account. We conclude that Alzheimer's disease is a clinically heterogeneous disorder whose manifestations can vary with age of onset. These differences indicate age-related vulnerabilities in this disease.<\/jats:p>","DOI":"10.1177\/1533317506299156","type":"journal-article","created":{"date-parts":[[2007,7,2]],"date-time":"2007-07-02T12:03:06Z","timestamp":1183377786000},"page":"218-222","source":"Crossref","is-referenced-by-count":48,"title":["Cognitive Differences between Early- and Late-Onset Alzheimer's Disease"],"prefix":"10.1177","volume":"22","author":[{"given":"Eliot A.","family":"Licht","sequence":"first","affiliation":[{"name":"Neurobehavior Unit, VA Greater Los Angeles Healthcare System, Department of Neurology, University of California at Los Angeles, Los Angeles, California, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, eliotlicht@ sbcglobal.net"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron M.","family":"McMurtray","sequence":"additional","affiliation":[{"name":"Neurobehavior Unit, VA Greater Los Angeles Healthcare System, Department of Neurology, University of California at Los Angeles, Los Angeles, California, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald E.","family":"Saul","sequence":"additional","affiliation":[{"name":"David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario F.","family":"Mendez","sequence":"additional","affiliation":[{"name":"Neurobehavior Unit, VA Greater Los Angeles Healthcare System, Department of Neurology, University of California at Los Angeles, Los Angeles, California, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2007,6,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1976.00500040001001"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.35.4.453"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(85)90021-1"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1986.00520060038014"},{"key":"atypb5","first-page":"333","volume":"26","author":"Ishii K.","year":"2005","journal-title":"AJNR Am J Neuroradiol."},{"key":"atypb6","unstructured":"Mendez MF \t\t\t\t,  \t\t\t\t\tCummings JL Dementia: A Clinical Approach 3rd ed.  \t\t\t\t\tPhiladelphia: Butterworth-Heinemann \t\t\t\t; 2003:1-12."},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1995.00540340045012"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.11.2412-a"},{"key":"atypb10","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","volume":"12","author":"Folstein MF","year":"1975","journal-title":"J Psychiatr Res."},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.4.609"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-107-4-481"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.11.1621"},{"key":"atypb14","doi-asserted-by":"crossref","unstructured":"Gladsjo JA \t\t\t\t,  \t\t\t\t\tSchuman CC \t\t\t\t,  \t\t\t\t\tEvans JD \t\t\t\t,  \t\t\t\t\tPeavy GM \t\t\t\t,  \t\t\t\t\tMiller SW \t\t\t\t,  \t\t\t\t\tHeaton RK Norms for letter and category fluency: demographic corrections for age, education, and ethnicity. Assessment 1999;147-178.","DOI":"10.1177\/107319119900600204"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1983.04050030037006"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.7.1215"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1177\/089198879400700108"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1159\/000058331"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000140289.18472.15"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2003.029876"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.74.6.715"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(02)00114-4"},{"key":"atypb23","volume-title":"D'Elia LF. Handbook of Normative Data for Neuropsychological Assessment","author":"Mitrushina MN","year":"1999"}],"container-title":["American Journal of Alzheimer's Disease &amp; Other Dementias\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1533317506299156","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1533317506299156","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:21:50Z","timestamp":1777368110000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1533317506299156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["10.1177\/1533317506299156"],"URL":"https:\/\/doi.org\/10.1177\/1533317506299156","relation":{},"ISSN":["1533-3175","1938-2731"],"issn-type":[{"value":"1533-3175","type":"print"},{"value":"1938-2731","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6]]}}}