{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:10:14Z","timestamp":1777381814906,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Alzheimers Dis Other Demen"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:p>Rationale: To compare and contrast structural and functional imaging in primary progressive aphasia (PPA). Methods: A cohort of 8 patients diagnosed with PPA presenting with nonfluency were prospectively evaluated. All patients had structural imaging in the form of MRI and in 1 patient CAT scanning on account of a cardiac pacemaker. All patients had single-photon emission computed tomography (SPECT) and positron emission tomography (PET) imaging. Results: SPECT and PET imaging had 100% correlation. Anatomical imaging was abnormal in only 6 of the 8 patients. Wernicke's area showed greater peak Z score reduction and extent of area affected than Broca's area (McNemar paired test: P = .008 for Z score reduction; P = .0003 for extent). PET scanning revealed significant involvement of the anterior cingulum. Conclusion: Functional imaging in PPA: ( a) identified more patients correctly than anatomic imaging highlighting the importance of SPECT and PET in the diagnosis; and ( b) demonstrated the heterogeneous involvement of disordered linguistic networks in PPA suggesting its syndromic nature.<\/jats:p>","DOI":"10.1177\/1533317507312621","type":"journal-article","created":{"date-parts":[[2008,1,11]],"date-time":"2008-01-11T20:55:08Z","timestamp":1200084908000},"page":"184-191","source":"Crossref","is-referenced-by-count":12,"title":["Correlative Studies of Structural and Functional Imaging in Primary Progressive Aphasia"],"prefix":"10.1177","volume":"23","author":[{"given":"P.K.","family":"Panegyres","sequence":"first","affiliation":[{"name":"Neurosciences Unit, Health Department of Western Australia, Mt Claremont, Neurodegenerative Disorders Research, Subiaco Western Australia, 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