{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:10:33Z","timestamp":1777381833386,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2008,2,7]],"date-time":"2008-02-07T00:00:00Z","timestamp":1202342400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Alzheimers Dis Other Demen"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:p>To date there are no conclusive reports on the usefulness of determining amyloid peptides in the serum of patients with Alzheimer's disease (AD). Only anecdotal works deal with the changes in the peptides produced by cholinesterase inhibitors. In this study, the authors investigated and studied the clinical significance of plasmatic A\u03b2-40 and A\u03b2-42 peptide levels in a series of 34 consecutive patients with AD. The baseline levels of the A\u03b2-40 peptide correlated negatively with the Mini Examen Cognoscitivo (Spanish version of the Mini-Mental test) score. Complete follow-up was possible in 22 patients. After 6 months of treatment with galantamine, the mean A\u03b2-40 peptide levels decreased from 31.86 to 24.22 pg\/mL. The baseline levels of A\u03b2-40 were predictive of response to treatment in the Alzheimer's Disease Assessment Scale\u2014Cognitive Subscale. The authors conclude that determining plasmatic A\u03b2-40 peptide levels could be useful in predicting and monitoring response to treatment in AD.<\/jats:p>","DOI":"10.1177\/1533317507313675","type":"journal-article","created":{"date-parts":[[2008,6,30]],"date-time":"2008-06-30T17:44:21Z","timestamp":1214847861000},"page":"286-290","source":"Crossref","is-referenced-by-count":3,"title":["The Clinical Significance of Plasmatic Amyloid A\u03b2-40 Peptide Levels in Alzheimer's Disease Patients Treated With Galantamine"],"prefix":"10.1177","volume":"23","author":[{"given":"Pedro J.","family":"Modrego","sequence":"first","affiliation":[{"name":"Neurology Department, Miguel Servet University Hospital,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inmaculada","family":"Monleon","sequence":"additional","affiliation":[{"name":"Araclon Biotech University of Zaragoza"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Sarasa","sequence":"additional","affiliation":[{"name":"Laboratory of Neurobiology, University of Zaragoza, Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,2,7]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70501-4"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.3.354"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(96)00143-8"},{"key":"atypb4","doi-asserted-by":"crossref","first-page":"117","DOI":"10.55782\/ane-2005-1544","volume":"65","author":"Sobow T.","year":"2005","journal-title":"Acta Neurobiol Exp"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.7.958"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e31803d3ae4"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(96)01363-7"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.57.1.100"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000191403.95453.6a"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1159\/000063605"},{"key":"atypb11","first-page":"340","volume":"43","author":"Sobow T.","year":"2005","journal-title":"Folia Neuropathol"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"atypb13","first-page":"189","volume":"7","author":"Lobo A.","year":"1979","journal-title":"Actas Luso Esp Neurol Psiquiatr Cienc Afines"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.141.11.1356"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.12.2308"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.5014\/ajot.53.5.471"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.6.1318"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2005.05.020"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000091890.32140.8F"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.04.067"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.08.036"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.105.090365"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(98)00236-8"},{"key":"atypb24","doi-asserted-by":"crossref","first-page":"131","DOI":"10.55782\/ane-2007-1640","volume":"67","author":"Sobow T.","year":"2007","journal-title":"Acta Neurobiol Exp (Wars)"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.0552"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200012)48:6<913::AID-ANA12>3.0.CO;2-S"}],"container-title":["American Journal of Alzheimer's Disease &amp; Other Dementias\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1533317507313675","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1533317507313675","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:22:02Z","timestamp":1777368122000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1533317507313675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2,7]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["10.1177\/1533317507313675"],"URL":"https:\/\/doi.org\/10.1177\/1533317507313675","relation":{},"ISSN":["1533-3175","1938-2731"],"issn-type":[{"value":"1533-3175","type":"print"},{"value":"1938-2731","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2,7]]}}}