{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T23:49:18Z","timestamp":1781135358606,"version":"3.54.1"},"reference-count":74,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2008,3,28]],"date-time":"2008-03-28T00:00:00Z","timestamp":1206662400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Alzheimers Dis Other Demen"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:p>The aim of this study is to systematically review the published literature on pharmacotherapy for inappropriate sexual behaviors in dementia. Literature search of the 5 databases (PubMed, MEDLINE, EMBASE, PsychINFO, and COCHRANE collaboration) and the analysis of the data available for the pharmacotherapeutic treatments of inappropriate sexual behaviors in dementia were carried out.There are no published randomized controlled trials of pharmacotherapy for inappropriate sexual behaviors in dementia, but available data from uncontrolled trials, case series, and individual case reports suggest efficacy for antidepressants, antipsychotics, mood stabilizers, hormonal agents, cimetidine, and pindolol for the treatment of these behaviors. Although there are no controlled data for the treatment of inappropriate sexual behaviors in dementia, available data suggest efficacy for some commonly used pharmacotherapeutic agents.<\/jats:p>","DOI":"10.1177\/1533317508318369","type":"journal-article","created":{"date-parts":[[2008,5,28]],"date-time":"2008-05-28T21:36:36Z","timestamp":1212010596000},"page":"344-354","source":"Crossref","is-referenced-by-count":41,"title":["Pharmacotherapy for Inappropriate Sexual Behaviors in Dementia: A Systematic Review of Literature"],"prefix":"10.1177","volume":"23","author":[{"given":"Banu","family":"Ozkan","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Wilkins","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunanda","family":"Muralee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh R.","family":"Tampi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2008,3,28]]},"reference":[{"key":"atypb1","unstructured":"Mortimer JA Alzheimer's disease and senile dementia: prevalence and incidence . In: Reisberg B, ed. Alzheimer's Disease: The Standard Reference. New York, NY: Free Press; 1983:141-148."},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-956757"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852900024317"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1177\/0891988705277541"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-8610(04)70093-6"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.157.1.86"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1983.tb03715.x"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1999.tb04583.x"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-199903000-00009"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2004.028043"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1177\/070674370104600104"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.57.11.1012"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022099026059"},{"key":"atypb14","first-page":"433","volume":"81","author":"Potocnik F.","year":"1992","journal-title":"S Afr Med J"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.158.2.280"},{"key":"atypb16","first-page":"368","volume":"48","author":"Cooper AJ","year":"1987","journal-title":"J Clin Psychiatry"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.2466\/pr0.1994.74.2.647"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.9.1141"},{"key":"atypb19","first-page":"415","volume":"67","author":"Monga TN","year":"1986","journal-title":"Arch Phys Med Rehabil"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1177\/07067437720176S211"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1977.00500200014003"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.49.8.867"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.12.1.71"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1097\/01.jcp.0000222518.01885.db"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1177\/070674379103600233"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-198510000-00010"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.139.7.913"},{"key":"atypb28","first-page":"171","volume":"65","author":"Akil M.","year":"1995","journal-title":"Adv Neurol"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.127.12.1691"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.135.12.1552"},{"key":"atypb31","unstructured":"Mc Lean PD Special award lecture: new findings on brain function and sociosexual behavior . In: Zubin J, Money J, eds. Contemporary Sexual Behaviors: Critical Issues in the 1970s. Baltimore, MD: Johns Hopkins University Press; 1973:53-74."},{"key":"atypb32","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/28.8.955"},{"key":"atypb33","first-page":"631","volume":"8","author":"Hashmi FH","year":"2000","journal-title":"Clin Geriatr"},{"key":"atypb34","doi-asserted-by":"publisher","DOI":"10.1080\/01614576.1986.11074859"},{"key":"atypb35","doi-asserted-by":"publisher","DOI":"10.1097\/00019442-200407000-00002"},{"key":"atypb36","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003945.pub2"},{"key":"atypb37","first-page":"422","volume":"43","author":"Sheldon LJ","year":"1998","journal-title":"Can J Psychiatry"},{"key":"atypb38","doi-asserted-by":"publisher","DOI":"10.1097\/00045391-200405000-00013"},{"key":"atypb39","doi-asserted-by":"publisher","DOI":"10.1345\/aph.10217"},{"key":"atypb40","doi-asserted-by":"publisher","DOI":"10.1023\/B:UROL.0000020338.21912.c2"},{"key":"atypb41","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-864127"},{"key":"atypb42","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjopharm.2006.12.007"},{"key":"atypb43","unstructured":"Tampi RR, van Dyck CH In: Miao-Kun Sun, ed. Chapter 11; Behavioral and Psychological Symptoms of Alzheimer's Disease. Research Progress in Alzheimer's Disease and Dementia. Hauppauge, NY: Blanchette Rockefeller Neuro-sciences Institute, Nova Publishers ; 2006:251-272."},{"key":"atypb44","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610207006540"},{"key":"atypb45","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2005.07.003"},{"key":"atypb46","doi-asserted-by":"publisher","DOI":"10.1097\/00019442-200303000-00004"},{"key":"atypb47","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2003.514204.x"},{"key":"atypb48","first-page":"78","volume":"10","author":"Chemali Z.","year":"2003","journal-title":"Prim Psychiatry"},{"key":"atypb49","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003154.pub3"},{"key":"atypb50","first-page":"191","volume":"47","author":"Simpson DM","year":"1986","journal-title":"J Clin Psychiatry"},{"key":"atypb51","doi-asserted-by":"publisher","DOI":"10.1177\/089198879500800210"},{"key":"atypb52","first-page":"169","volume":"52","author":"Perilstein RD","year":"1991","journal-title":"J Clin Psychiatry"},{"key":"atypb53","first-page":"33","volume":"55","author":"McElroy SL","year":"1994","journal-title":"J Clin Psychiatry."},{"key":"atypb54","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(98)00070-5"},{"key":"atypb55","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.154.10.1474a"},{"key":"atypb56","first-page":"81","volume":"8","author":"Raji M.","year":"2000","journal-title":"Ann Long Term Care"},{"key":"atypb57","doi-asserted-by":"publisher","DOI":"10.4088\/PCC.v08n0208b"},{"key":"atypb58","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4943(02)00026-2"},{"issue":"8","key":"atypb59","first-page":"29","volume":"60","author":"Maixner SM","year":"1999","journal-title":"J Clin Psychiatry"},{"key":"atypb60","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2000.tb04737.x"},{"key":"atypb61","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-8301.2004.00060.x"},{"key":"atypb62","doi-asserted-by":"publisher","DOI":"10.1177\/070674378603100116"},{"key":"atypb63","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.145.8.1037a"},{"key":"atypb64","first-page":"132","volume":"31","author":"Light SA","year":"2006","journal-title":"J Psychiatry Neurosci"},{"key":"atypb65","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)90723-G"},{"key":"atypb66","first-page":"609","volume":"612","author":"Lothstein LM","year":"1997","journal-title":"Conn Med"},{"key":"atypb67","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1991.tb02878.x"},{"key":"atypb68","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-199510000-00007"},{"key":"atypb69","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870090317"},{"key":"atypb70","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.10.2024"},{"key":"atypb71","volume-title":"Goodman & Gilman's Pharmacological Basis of Therapeutics","author":"Brunton LL","year":"2008"},{"key":"atypb72","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1989.tb02278.x"},{"key":"atypb73","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1166(199703)12:3<331::AID-GPS495>3.0.CO;2-J"},{"key":"atypb74","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1177\/002383099200500108","volume":"5","author":"O'Donnell BF","year":"1992","journal-title":"J Geriatr Psychiatry Neurol"}],"container-title":["American Journal of Alzheimer's Disease &amp; Other Dementias\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1533317508318369","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1533317508318369","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:22:05Z","timestamp":1777368125000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1533317508318369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,28]]},"references-count":74,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["10.1177\/1533317508318369"],"URL":"https:\/\/doi.org\/10.1177\/1533317508318369","relation":{},"ISSN":["1533-3175","1938-2731"],"issn-type":[{"value":"1533-3175","type":"print"},{"value":"1938-2731","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,28]]}}}