{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:11:29Z","timestamp":1777381889695,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2009,4,21]],"date-time":"2009-04-21T00:00:00Z","timestamp":1240272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Alzheimers Dis Other Demen"],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:p>Objectives: To evaluate the efficacy and tolerability of donepezil in patients with Binswanger type subcortical vascular dementia. Methods: Patients (n = 34, mean age = 71.8 + 7.12) with Binswanger type subcortical vascular dementia from 8 multicenter, according to clinical and neuroradiological working criteria, were selected to receive donepezil 5 mg\/day (n = 2) or donepezil 10 mg\/day (n = 32, after 5 mg\/day) for 24 weeks. Our primary endpoints were change from baseline to weeks 12 and 24 in the Seoul Neuropsychological Screening Battery-Dementia version (SNSB-D) and the Korean version of neuropsychiatric inventory (K-NPI). Results: A total of 24 patients received donepezil completed the study (mean age = 72.0 + 7.5 K-Mini-Mental State Examination [MMSE] = 21.0 + 5.1). After 12 weeks and 24 weeks, patients showed improvements in cognitive function on the SNSB-D compared baseline of 16.29 points at 12 weeks (P &lt; .05) and 12.44 points at 24 weeks (P &lt; .05). Significant improvements were shown in only memory domain, immediate verbal recall and delayed recall tests. Subgroup with better cognitive function (SNSB-D &gt; 100) were more effective in frontal and memory domains than the other subgroup (SNSB-D &lt; 100). Withdrawal rates due to adverse events were very low (4.16%). Conclusions: Donepezil-treated patients with Binswanger type subcortical vascular dementia demonstrated significant improvement in cognition compared with baseline, and donepezil was well tolerated.<\/jats:p>","DOI":"10.1177\/1533317509334960","type":"journal-article","created":{"date-parts":[[2009,4,21]],"date-time":"2009-04-21T23:44:45Z","timestamp":1240357485000},"page":"293-301","source":"Crossref","is-referenced-by-count":9,"title":["A Multicenter, Open-Label, 24-Week Follow-Up Study for Efficacy on Cognitive Function of Donepezil in Binswanger-Type Subcortical Vascular Dementia"],"prefix":"10.1177","volume":"24","author":[{"family":"Jay Cheol Kwon","sequence":"first","affiliation":[{"name":"Department of Neurology, Changwon Fatima Hospital, Changwon,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Eung Gyu Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Inje University Pusan Paik Hospital, Busan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Jae Woo Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Dong-A University Medical Center, Busan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Oh Dae Kwon","sequence":"additional","affiliation":[{"name":"Department of Radiology, Daegu Catholic University Medical Center, Daegu"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Bong Goo Yoo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kosin University Gospel Hospital, Busan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Hyon Ah Yi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Keimyung University Dongsan Medical Center, Daegu"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Nack Cheon Choi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Gyeongsang National University Hospital, Jinju"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Seon Young Ahn","sequence":"additional","affiliation":[{"name":"Department of Neurology, Changwon Fatima Hospital, Changwon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Byung Hwa Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, School of Medicine, Sung Kyun Kwon University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Myong Jin Kang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Dong-A University Medical Center, Busan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Dae Seob Choi","sequence":"additional","affiliation":[{"name":"Department of Radiology, , Gyeongsang National University Hospital, Jinju"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"BKVD Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,4,21]]},"reference":[{"key":"atypb1","unstructured":"Meyer JS, Rauch GM Classification of subtypes of vascular dementia including subcortical versus cortical dementias. In: Meyer JS , Rauch GM, Lechner H, Loeb C, Toole JF , eds. Vascular Dementia. Armonk, NY : Futura Publishing Co, Inc; 2001 :203-207."},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1159\/000049152"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.3.695"},{"key":"atypb4","first-page":"23","volume":"59","author":"T. Erkinjuntti","year":"2000","journal-title":"J Neural Transm"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/121.12.2249"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.3.489"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.4.613"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb04854.x"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb04859.x"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000091396.95360.E1"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000078943.50032.FC"},{"key":"atypb12","unstructured":"Mendez MF, Cummings JL Dementia: significance, definition, and epidemiology. In Dementia-A clinical approach. 3rd edn. Philadelphia, PA: Butterworth-Heinemann Publishers ; 2003: 1-12."},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1990.00530020047013"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/16.1.19"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.8.1614"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13616-1"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.069120"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000168877.06011.15"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1159\/000078625"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1016\/S1098-3597(01)90047-X"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.11.1626"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1080\/13854040490507136"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.55.9.1217"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.3.473"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1007\/BF01271206"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1159\/000084553"}],"container-title":["American Journal of Alzheimer's Disease &amp; Other Dementias\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1533317509334960","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1533317509334960","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:22:16Z","timestamp":1777368136000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1533317509334960"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4,21]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["10.1177\/1533317509334960"],"URL":"https:\/\/doi.org\/10.1177\/1533317509334960","relation":{},"ISSN":["1533-3175","1938-2731"],"issn-type":[{"value":"1533-3175","type":"print"},{"value":"1938-2731","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,21]]}}}