{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:11:29Z","timestamp":1777381889917,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2009,6,26]],"date-time":"2009-06-26T00:00:00Z","timestamp":1245974400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Alzheimers Dis Other Demen"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:p>We describe a 64-year-old male who presented with a 2-year history of behavioral and cognitive decline. Brain imaging showed nonenhancing hemispheric white matter lesions. Blood work revealed elevated thyroglobulin and thyroperoxidase antibody levels. Cerebrospinal fluid (CSF) analysis was largely negative, except for an elevated protein and immunoglobulin G (IgG) level. Because of the absence of stroke, central nervous system (CNS) tumor, or infection, this patient fits into criteria of Hashimoto\u2019s encephalopathy. His Mini-Mental State Examination score improved from 10 to 29 after initial immunotherapy. The patient remained stable over 6 months with monthly outpatient total plasma exchange, but symptoms recurred within 3 months when the outpatient therapy was discontinued. A follow-up CSF IgG level was found to be increased and the treatment was repeated with partial clinical improvement and decline in CSF IgG level. He then underwent high dose steroid treatment after which patients\u2019 clinical condition stabilized and CSF analysis showed even further IgG decline.<\/jats:p>","DOI":"10.1177\/1533317509339162","type":"journal-article","created":{"date-parts":[[2009,6,26]],"date-time":"2009-06-26T22:24:37Z","timestamp":1246055077000},"page":"373-376","source":"Crossref","is-referenced-by-count":6,"title":["Cerebrospinal Immunoglobulin Level Changes and Clinical Response to Treatment of Hashimoto\u2019s Encephalopathy"],"prefix":"10.1177","volume":"24","author":[{"given":"Gediminas","family":"Gliebus","sequence":"first","affiliation":[{"name":"Department of Neurology, Drexel University College of Medicine, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol F.","family":"Lippa","sequence":"additional","affiliation":[{"name":"Department of Neurology, Drexel University College of Medicine, Philadelphia, Pennsylvania,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,6,26]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(66)92876-5"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(00)00302-6"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.18.1.14"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1007\/BF00900946"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1089\/105072502760043477"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.70.1.132"},{"issue":"2","key":"atypb7","first-page":"80","volume":"104","author":"Nieuwenhuis L.","year":"2004","journal-title":"Acta Neurol Belg"},{"issue":"10","key":"atypb8","doi-asserted-by":"crossref","first-page":"799","DOI":"10.2165\/00023210-200721100-00002","volume":"21","author":"Mocellin R.","year":"2007","journal-title":"CNS Drugs"},{"issue":"3","key":"atypb9","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","volume":"12","author":"Folstein MF","year":"1975","journal-title":"J Psychiat Res"},{"issue":"19","key":"atypb10","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.2174\/0929867033456945","volume":"10","author":"Chaudhuri A.","year":"2003","journal-title":"Curr Med Chem"},{"issue":"2","key":"atypb11","first-page":"191","volume":"32","author":"Shibata N.","year":"1992","journal-title":"Rinsho Shinkeigaku"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.2.197"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2004.00542.x"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000048660.71390.C6"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2005.02.004"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2007.01.018"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.68.5.681"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1080\/00207450490422731"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1984.61.5.0901"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2005.04.007"}],"container-title":["American Journal of Alzheimer's Disease &amp; Other Dementias\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1533317509339162","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1533317509339162","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:22:17Z","timestamp":1777368137000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1533317509339162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6,26]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["10.1177\/1533317509339162"],"URL":"https:\/\/doi.org\/10.1177\/1533317509339162","relation":{},"ISSN":["1533-3175","1938-2731"],"issn-type":[{"value":"1533-3175","type":"print"},{"value":"1938-2731","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6,26]]}}}