{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:51:23Z","timestamp":1792651883243,"version":"4.5.0"},"reference-count":43,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2010,5,19]],"date-time":"2010-05-19T00:00:00Z","timestamp":1274227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Alzheimers Dis Other Demen"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:p>This report examines the relation of upper and lower extremity motor performance to functional impairment among 371 persons with probable Alzheimer\u2019s disease (AD). Cognitive and motor performance tests were administered at 6-month intervals for up to 4 years. Motor performance was assessed using 3 lower extremity tests and 2 upper extremity tests. Functional impairment was measured at 3-month intervals using caregiver ratings of impairments in activities of daily living, mobility, and range of motion. Both lower and upper extremity performance were inversely related to functional impairments on all 3 scales (all Ps &lt; .001), after controlling for age, sex, and level of cognitive impairment. This suggests that motor performance contributes to functional impairments in AD, independent of cognitive impairment. It is important to preserve motor performance in individuals with AD because it influences physical function throughout the course of the disease.<\/jats:p>","DOI":"10.1177\/1533317510367636","type":"journal-article","created":{"date-parts":[[2010,5,19]],"date-time":"2010-05-19T23:46:12Z","timestamp":1274312772000},"page":"425-431","source":"Crossref","is-referenced-by-count":43,"title":["Upper and Lower Extremity Motor Performance and Functional Impairment in Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"25","author":[{"given":"Liesi E.","family":"Hebert","sequence":"first","affiliation":[{"name":"Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL, USA, , Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia L.","family":"Bienias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith J.","family":"McCann","sequence":"additional","affiliation":[{"name":"Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL, USA, College of Nursing, Rush University Medical Center, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Scherr","sequence":"additional","affiliation":[{"name":"National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA, Department of Behavorial Sciences, Rush University Medical Center, Chicago, IL, USA, Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis A.","family":"Evans","sequence":"additional","affiliation":[{"name":"Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL, USA, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,5,19]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.88.10.1452"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1159\/000051259"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1159\/000058355"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1002\/gps.930080709"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1995.tb07006.x"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1168"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1097\/01.wad.0000157065.43282.bc"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000154529.53488.30"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2007.00800.x"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.62.2.297"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1080\/03610730601006370"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1997.00550200033007"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.6.1284"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/54.4.M191"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1177\/153331750101600512"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000158423.05224.7F"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.2.226"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20723"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-006-0146-9"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.9.1689"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.12.2300"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000162054.15428.E9"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/50A.5.M235"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"issue":"3","key":"atypb25","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","volume":"12","author":"Folstein MF","year":"1975","journal-title":"J Psychiatr Res"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1992.tb01992.x"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2007.164.6.910"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000140488.65299.53"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/53A.4.M295"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/52A.6.M363"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/49.2.M85"},{"key":"atypb32","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/55.4.M221"},{"issue":"6","key":"atypb33","first-page":"410","volume":"6","author":"Guralnik JM","year":"1994","journal-title":"Aging (Milano)"},{"key":"atypb34","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/60.5.S263"},{"key":"atypb35","volume-title":"The Halstead-Reitan Neuropsychological Test Battery: Theory and Interpretation","author":"Reitan RM","year":"1985"},{"key":"atypb36","doi-asserted-by":"publisher","DOI":"10.1037\/h0061266"},{"key":"atypb37","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.74.3.266"},{"key":"atypb38","volume-title":"International classification of impairments, disabilities and handicaps","author":"World Health Organization.","year":"1980"},{"key":"atypb39","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/73.1.13"},{"key":"atypb40","doi-asserted-by":"publisher","DOI":"10.2307\/2531248"},{"key":"atypb41","volume-title":"SAS\/STAT(r) User\u2019s Guide, Version 8","author":"SAS Institute Inc.","year":"2000"},{"key":"atypb42","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-004-0033-9"},{"key":"atypb43","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.15.2015"}],"container-title":["American Journal of Alzheimer's Disease &amp; Other Dementias\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1533317510367636","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1533317510367636","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:22:29Z","timestamp":1777368149000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1533317510367636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,19]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["10.1177\/1533317510367636"],"URL":"https:\/\/doi.org\/10.1177\/1533317510367636","relation":{},"ISSN":["1533-3175","1938-2731"],"issn-type":[{"value":"1533-3175","type":"print"},{"value":"1938-2731","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,19]]}}}