{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:12:38Z","timestamp":1777381958027,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2010,6,17]],"date-time":"2010-06-17T00:00:00Z","timestamp":1276732800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Alzheimers Dis Other Demen"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:p>The aim of this 12-week, open-label study was to determine the safety and efficacy of donepezil in participants with Alzheimer\u2019s disease (AD) residing in assisted living facilities (ALFs). Participants received 5 mg donepezil daily for 6 weeks followed by 10 mg daily for 6 weeks. Primary and secondary outcomes were change from baseline in Mini-Mental State Examination (MMSE) and Neuropsychiatric Inventory 8 (NPI-8) scores, respectively. Safety was assessed by adverse events (AEs) and laboratory tests. Of the 97 participants, 76 completed the study. Mean MMSE score (18.7 at baseline) improved 1.8 points (P &lt; .0001) at study end. Total NPI-8 score improved 1.8 points (P = .043). The most frequent AEs were nausea and diarrhea. Donepezil improved cognition and behavior and was safe and well tolerated. The results suggest a need for proactive screening and diagnosis of AD and support the value of treatment and use of donepezil in participants residing in ALFs.<\/jats:p>","DOI":"10.1177\/1533317510372923","type":"journal-article","created":{"date-parts":[[2010,6,17]],"date-time":"2010-06-17T23:37:51Z","timestamp":1276817871000},"page":"483-489","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy and Safety of Donepezil in Patients With Alzheimer\u2019s Disease in Assisted Living Facilities"],"prefix":"10.1177","volume":"25","author":[{"given":"Adam","family":"Rosenblatt","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins School of Medicine, Baltimore, MD, USA,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeff","family":"Gao","sequence":"additional","affiliation":[{"name":"Eisai Inc, Woodcliff Lake, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Mackell","sequence":"additional","affiliation":[{"name":"Pfizer Inc, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Richardson","sequence":"additional","affiliation":[{"name":"Eisai Inc, Woodcliff Lake, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,6,17]]},"reference":[{"key":"atypb1","volume-title":"Assisted living in the United States","author":"Wright B.","year":"2009"},{"key":"atypb2","volume-title":"State assisted living policy 2002","author":"Mollica R.","year":"2009"},{"key":"atypb3","volume-title":"Resident profile. 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