{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:31:17Z","timestamp":1790339477708,"version":"4.1.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Alzheimers Dis Other Demen"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:p>Relationship between late-life hypertension and Alzheimer\u2019s disease (AD) remains less clear. Both cross-sectional and longitudinal methods were used to examine whether systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP), mean arterial pressure (MAP), and self-reported hypertension (S-HTN) in late life were associated with having and developing AD. The cross-sectional examination included 1768 individuals with AD and 818 nondemented individuals, and AD was not significantly associated with S-HTN or any of blood pressure measures (S-HTN: P = .236; SBP: P = .095; DBP: P = .429; PP: P = .145; MAP: P = .162). In the longitudinal examination, 594 nondemented individuals, 171 with and 423 without S-HTN at entry, were included. Diastolic blood pressure was significantly related to the development of AD ( P = .030) but not S-HTN ( P = .251), SBP ( P = .294) PP ( P = .919), and MAP ( P = .060). The association underscores the necessity of further investigation to outline the detailed mechanisms and biological relevance, if any, of late-life DBP to later AD.<\/jats:p>","DOI":"10.1177\/1533317511421779","type":"journal-article","created":{"date-parts":[[2011,9,16]],"date-time":"2011-09-16T06:12:22Z","timestamp":1316153542000},"page":"457-462","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["Relationship Between Late-Life Hypertension, Blood Pressure, and Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"26","author":[{"given":"Yuan-Han","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan"},{"name":"Department of and Master\u2019s Program in Neurology, Kaohsiung Medical University, Kaohsiung, Taiwan"},{"name":"Charles F. and Joanne Knight Alzheimer\u2019s Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine M.","family":"Roe","sequence":"additional","affiliation":[{"name":"Charles F. and Joanne Knight Alzheimer\u2019s Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA"},{"name":"Departments of Neurology, Washington University School of Medicine, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Morris","sequence":"additional","affiliation":[{"name":"Charles F. and Joanne Knight Alzheimer\u2019s Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA"},{"name":"Departments of Neurology, Washington University School of Medicine, St. Louis, MO, USA"},{"name":"Departments of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, 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