{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T12:39:16Z","timestamp":1791031156879,"version":"4.1.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Alzheimers Dis Other Demen"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:p>Objective: We conducted a case\u2013control study to investigate whether clusterin polymorphism (rs11136000) was associated with late-onset Alzheimer\u2019s disease in Chinese Han population. Methods: Polymerase chain reaction\u2013restriction fragment length polymorphism (PCR-RFLP) assay was performed on genotype rs11136000 and APOE\u03b54 in 127 patients with late-onset Alzheimer\u2019s disease and 143 control individuals. Previous published data from other Chinese samples was also included for further meta-analysis. Results: APOE\u03b54 was demonstrated to increase the risk of Alzheimer\u2019s disease in Chinese population (odds ratio = 2.35, 95% confidence interval: 1.40-3.96). There is no significant association between clusterin rs11136000 with late-onset sporadic AD in our small cohort. However, meta-analysis revealed significant allele and genotype differences between Alzheimer\u2019s disease and controls following a recessive model. Conclusion: Clusterin (rs11136000) was associated with Alzheimer\u2019s disease in Chinese Han population.<\/jats:p>","DOI":"10.1177\/1533317511432735","type":"journal-article","created":{"date-parts":[[2012,2,2]],"date-time":"2012-02-02T12:13:52Z","timestamp":1328184832000},"page":"627-630","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":33,"title":["Association Study of\n                    <i>Clusterin<\/i>\n                    Polymorphism rs11136000 With Late Onset Alzheimer\u2019s Disease in Chinese Han Population"],"prefix":"10.1177","volume":"26","author":[{"given":"Jian-Fang","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Neurology & Institute of Neurology, Ruijin Hospital affiliated to the Shanghai Jiao Tong University School of Medicine, Shanghai, 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Ruijin Hospital affiliated to the Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Jing","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Neurology & Institute of Neurology, Ruijin Hospital affiliated to the Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Zhou","family":"Fei","sequence":"additional","affiliation":[{"name":"Department of Neurology & Institute of Neurology, Ruijin Hospital affiliated to the Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Qing","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Neurology & Institute of Neurology, Ruijin Hospital affiliated to the Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Lab of 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