{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:16:32Z","timestamp":1777382192208,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2012,8,17]],"date-time":"2012-08-17T00:00:00Z","timestamp":1345161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Alzheimers Dis Other Demen"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The aim was to examine the gene environment (GxE) interaction with reference to APO E genotypes, serum lipids and organochlorine pesticides (OCPs) as one of the factors in the etiology of Alzheimer\u2019s disease (AD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A case control study was used to examine, APOE HhaI polymorphism by polymerase chain reaction (PCR)\/PCRrestriction fragment length polymorphism method, serum lipids by autoanalyser and OCPs by gas chromatography (GC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>APOE \u220a4 allele frequency was significantly high (p=0.000, OR=5.73, CI=2.68-12.50) in AD as compared to controls. The serum cholesterol, \u03b2- hexachlorocyclohexane and dieldrin are risk factors for AD independent of the APOE \u220a4 risk allele, recording an odds ratio of 1.16, 11.38 and 10.45 respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>GxE interactions exist with APOE \u220a4 allele status that need to be considered for the study design and analysis of such data in future studies of AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1533317512456067","type":"journal-article","created":{"date-parts":[[2012,8,17]],"date-time":"2012-08-17T20:26:00Z","timestamp":1345235160000},"page":"496-503","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Gene\u2013Environment Interaction in Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"27","author":[{"given":"Neeraj Kumar","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Neurochemistry, Institute of Human Behaviour and Allied Sciences, Dilshad Garden, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neelam","family":"Chhillar","sequence":"additional","affiliation":[{"name":"Department of Neurochemistry, Institute of Human Behaviour and Allied Sciences, Dilshad Garden, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. D.","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Environmental Biochemistry Laboratory, UCMS & G.T.B. Hospital (University of Delhi), Dilshad Garden, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiran","family":"Bala","sequence":"additional","affiliation":[{"name":"Department of Neurology, Institute of Human Behaviour and Allied Sciences, Dilshad Garden, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajit Kumar","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Division of Reproductive and Child Health, ICMR, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. D.","family":"Mustafa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Environmental Biochemistry Laboratory, UCMS & G.T.B. Hospital (University of Delhi), Dilshad Garden, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Mitrabasu","sequence":"additional","affiliation":[{"name":"Health Centre, Institute of Nuclear Medicine and Allied Sciences, DRDO, Timarpur, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,8,17]]},"reference":[{"key":"bibr1-1533317512456067","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM2003ra020003"},{"key":"bibr2-1533317512456067","doi-asserted-by":"publisher","DOI":"10.1159\/000117083"},{"key":"bibr3-1533317512456067","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70325-2"},{"key":"bibr4-1533317512456067","doi-asserted-by":"publisher","DOI":"10.1126\/science.8346443"},{"key":"bibr5-1533317512456067","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/155.6.487"},{"key":"bibr6-1533317512456067","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000194507.39504.17"},{"key":"bibr7-1533317512456067","doi-asserted-by":"publisher","DOI":"10.1006\/enrs.2001.4254"},{"key":"bibr8-1533317512456067","first-page":"859101","volume":"2010","author":"Chouliaras L","year":"2010","journal-title":"Int J Alzheimers Dis"},{"key":"bibr9-1533317512456067","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2010.01.002"},{"key":"bibr10-1533317512456067","doi-asserted-by":"publisher","DOI":"10.1016\/j.crvi.2007.02.018"},{"key":"bibr11-1533317512456067","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-200005000-00009"},{"key":"bibr12-1533317512456067","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2008.10.061"},{"key":"bibr13-1533317512456067","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"bibr14-1533317512456067","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/16.3.1215"},{"key":"bibr15-1533317512456067","doi-asserted-by":"publisher","DOI":"10.1159\/000105483"},{"key":"bibr16-1533317512456067","doi-asserted-by":"publisher","DOI":"10.1007\/s00128-008-9459-9"},{"key":"bibr17-1533317512456067","doi-asserted-by":"publisher","DOI":"10.1007\/BF01056331"},{"key":"bibr18-1533317512456067","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)88963-3"},{"key":"bibr19-1533317512456067","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(87)90639-9"},{"issue":"2","key":"bibr20-1533317512456067","first-page":"118","volume":"7","author":"Kapur S","year":"2006","journal-title":"JIACM"},{"key":"bibr21-1533317512456067","doi-asserted-by":"publisher","DOI":"10.1353\/hub.2001.0012"},{"key":"bibr22-1533317512456067","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2012-111385"},{"key":"bibr23-1533317512456067","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2004-6602"},{"key":"bibr24-1533317512456067","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2007.10.005"},{"key":"bibr25-1533317512456067","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.2001.0422"},{"key":"bibr26-1533317512456067","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.297"},{"key":"bibr27-1533317512456067","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00-0815fje"},{"key":"bibr28-1533317512456067","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-9-128"},{"key":"bibr29-1533317512456067","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5170-04.2005"},{"key":"bibr30-1533317512456067","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)31529-6"},{"key":"bibr31-1533317512456067","doi-asserted-by":"publisher","DOI":"10.1097\/00041433-199906000-00003"},{"key":"bibr32-1533317512456067","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M304814200"},{"key":"bibr33-1533317512456067","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2009.12.007"},{"key":"bibr34-1533317512456067","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/60.8.759"},{"key":"bibr35-1533317512456067","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.89"},{"key":"bibr36-1533317512456067","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410360119"},{"key":"bibr37-1533317512456067","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2006.12.020"},{"key":"bibr38-1533317512456067","doi-asserted-by":"publisher","DOI":"10.1186\/1756-6606-1-12"}],"container-title":["American Journal of Alzheimer's Disease &amp; 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