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As individuals with DLB are predisposed to psychotic symptoms that might be exacerbated by dopaminergic stimulation, modafinil is considered to be an attractive option for the treatment of EDS in DLB. We describe 2 cases in which administration of modafinil exacerbated agitation and hallucinations in DLB, and we also review data that may explain the mechanisms underlying this effect. In both cases, psychotic symptoms emerged concomitantly with modafinil administration and remitted following its discontinuation. Although definitive data regarding the benefits and adverse effects of modafinil for the treatment of EDS in DLB await controlled prospective randomized studies, our observations warrant caution regarding its use in this context.<\/jats:p>","DOI":"10.1177\/1533317512456450","type":"journal-article","created":{"date-parts":[[2012,8,14]],"date-time":"2012-08-14T22:04:34Z","timestamp":1344981874000},"page":"468-473","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Agitation and Psychosis Associated With Dementia With Lewy Bodies Exacerbated by Modafinil Use"],"prefix":"10.1177","volume":"27","author":[{"given":"Eduardo","family":"Prado","sequence":"first","affiliation":[{"name":"Department of Psychiatry, State University of Londrina, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pongsatorn","family":"Paholpak","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Srinagarind Hospital, Khon Kaen University, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myha","family":"Ngo","sequence":"additional","affiliation":[{"name":"Mary S. 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