{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T05:30:41Z","timestamp":1781760641521,"version":"3.54.5"},"reference-count":27,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2012,9,23]],"date-time":"2012-09-23T00:00:00Z","timestamp":1348358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Alzheimers Dis Other Demen"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p>The aims were to assess dysautonomia in Alzheimer\u2019s Disease (AD), clinically and electrophysiologically, using sympathetic skin response (SSR) test and R-R interval variation (RRIV) test and to analyze the relationship between symptoms of dysautonomia and SSR\/RRIV results. A tota of 54 patients with AD and 37 controls were evaluated using Autonomic Symptoms Questionnaire and SSR\/RRIV test. Clinical dysautonomia was observed in 66% of patients (eg, orthostatic hypotension in 34.5%, constipation in 17.2%, urinary incontinence in 13.8%). The SSR test was abnormal in 26%, but the RRIV test was abnormal in 97.7% of cases; there was significant difference in RRIV test results between AD and controls (R mean 8.05% and 14.6%, respectively). In AD, clinical dysautonomia occurs at a various degree, and the abnormal SSR and RRIV test results were not always related to the presence of clinical dysautonomia; this observation points that the tests could be used as a useful tool in the assessment of subclinical dysautonomia.<\/jats:p>","DOI":"10.1177\/1533317512459792","type":"journal-article","created":{"date-parts":[[2012,9,24]],"date-time":"2012-09-24T20:24:55Z","timestamp":1348518295000},"page":"592-599","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Clinical and Functional Assessment of Dysautonomia and Its Correlation in Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"27","author":[{"given":"Beata","family":"Zakrzewska-Pniewska","sequence":"first","affiliation":[{"name":"Department of Neurology, Medical University of Warsaw, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata","family":"Gawel","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical University of Warsaw, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elzbieta","family":"Szmidt-Salkowska","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical University of Warsaw, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Kepczynska","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical University of Warsaw, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Nojszewska","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical University of Warsaw, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,9,23]]},"reference":[{"key":"bibr1-1533317512459792","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"bibr2-1533317512459792","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1166(1998110)13:11<785::AID-GPS872>3.0.CO;2-U"},{"issue":"9","key":"bibr3-1533317512459792","first-page":"1020","volume":"30","author":"Yamamoto T","year":"1990","journal-title":"Rinsho Shinkeigaku"},{"key":"bibr4-1533317512459792","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2009.01.011"},{"key":"bibr5-1533317512459792","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0594.2008.00456.x"},{"key":"bibr6-1533317512459792","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1995.tb05836.x"},{"key":"bibr7-1533317512459792","doi-asserted-by":"publisher","DOI":"10.1007\/BF03160569"},{"key":"bibr8-1533317512459792","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(93)90233-4"},{"key":"bibr9-1533317512459792","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/23.5.400"},{"issue":"40","key":"bibr10-1533317512459792","first-page":"180","volume":"7","author":"Paradowski B","year":"1999","journal-title":"Pol Merkuriusz Lek"},{"key":"bibr11-1533317512459792","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"bibr12-1533317512459792","first-page":"3","volume-title":"Clinical Autonomic Disorders. 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