{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:56:13Z","timestamp":1777380973383,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2012,10,4]],"date-time":"2012-10-04T00:00:00Z","timestamp":1349308800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Alzheimers Dis Other Demen"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:p>Apolipoprotein E ( ApoE) gene polymorphisms are thought to be the most important genetic risk factor in the pathogenesis of late onset and sporadic Alzheimer\u2019s disease (AD). Moreover, interleukin-1\u03b1 ( IL-1\u03b1) is found to be associated with the pathogenesis of AD. In this research, \u220a2, \u220a3, and \u220a4 polymorphisms of ApoE gene and C889T polymorphism of IL-1\u03b1 gene were genotyped in patients with AD and controls. Genotyping was performed by real-time polymerase chain reaction. \u220a3\/\u220a3 and \u220a3\/\u220a4 genotype frequencies were significantly higher in control and case groups, respectively. While \u220a3 allele frequencies were significantly higher in the control group, \u220a2 and \u220a4 allele frequencies were significantly higher among the cases with AD. No difference was found between the groups according to C889T polymorphism of IL-1\u03b1. In conclusion, we demonstrated that there was a strong association between ApoE \u220a4 allele and AD, while there was no relation with IL-1\u03b1 C889T polymorphisms for this study.<\/jats:p>","DOI":"10.1177\/1533317512461557","type":"journal-article","created":{"date-parts":[[2012,10,4]],"date-time":"2012-10-04T21:24:33Z","timestamp":1349385873000},"page":"756-761","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Association of Alzheimer's Disease With\n                    <i>APOE<\/i>\n                    and\n                    <i>IL-1\u03b1<\/i>\n                    Gene Polymorphisms"],"prefix":"10.1177","volume":"30","author":[{"given":"Saliha Handan","family":"Yildiz","sequence":"first","affiliation":[{"name":"Department of Medical Genetics, Afyon Kocatepe University, Afyonkarahisar, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mujgan Ozdemir","family":"Erdogan","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Afyon Kocatepe University, Afyonkarahisar, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sevilhan","family":"Artan","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Eskisehir Osmangazi University, Eskisehir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Solak","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Afyon Kocatepe University, Afyonkarahisar, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Yaman","sequence":"additional","affiliation":[{"name":"Department of Neurology, Afyon Kocatepe University, Afyonkarahisar, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belgin Demet","family":"Ozbabalik","sequence":"additional","affiliation":[{"name":"Department of Neurology, Eskisehir Osmangazi University, Eskisehir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evrim Suna Arikan","family":"Terzi","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Afyon Kocatepe University, Afyonkarahisar, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,10,4]]},"reference":[{"key":"bibr1-1533317512461557","volume":"8","author":"Koivisto A.","year":"2006","journal-title":"Department of Neurology Series of Reports"},{"key":"bibr2-1533317512461557","doi-asserted-by":"publisher","DOI":"10.1385\/JMN:17:2:101"},{"key":"bibr3-1533317512461557","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.26.043002.094919"},{"key":"bibr4-1533317512461557","doi-asserted-by":"publisher","DOI":"10.1007\/s10048-003-0157-9"},{"key":"bibr5-1533317512461557","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70159-9"},{"key":"bibr6-1533317512461557","doi-asserted-by":"publisher","DOI":"10.1126\/science.3513311"},{"key":"bibr7-1533317512461557","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2006.08.048"},{"key":"bibr8-1533317512461557","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)34443-6"},{"key":"bibr9-1533317512461557","doi-asserted-by":"publisher","DOI":"10.1385\/JMN:23:3:157"},{"key":"bibr10-1533317512461557","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03550160069041"},{"key":"bibr11-1533317512461557","doi-asserted-by":"publisher","DOI":"10.1126\/science.8346443"},{"key":"bibr12-1533317512461557","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91705-Q"},{"key":"bibr13-1533317512461557","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)03367-4"},{"key":"bibr14-1533317512461557","doi-asserted-by":"publisher","DOI":"10.1172\/JCI36663"},{"key":"bibr15-1533317512461557","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4026-09.2009"},{"key":"bibr16-1533317512461557","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)01661-1"},{"key":"bibr17-1533317512461557","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-002-0819-9"},{"key":"bibr18-1533317512461557","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/59.6.471"},{"key":"bibr19-1533317512461557","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2000.0740143.x"},{"key":"bibr20-1533317512461557","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-004-0148-5"},{"key":"bibr21-1533317512461557","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200003)47:3<361::AID-ANA12>3.0.CO;2-N"},{"key":"bibr22-1533317512461557","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200003)47:3<365::AID-ANA13>3.0.CO;2-G"},{"key":"bibr23-1533317512461557","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.47.1.387"},{"key":"bibr24-1533317512461557","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.8.1467"},{"key":"bibr25-1533317512461557","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2007.00130.x"},{"key":"bibr26-1533317512461557","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2011.03405.x"},{"key":"bibr27-1533317512461557","doi-asserted-by":"publisher","DOI":"10.1038\/ng0694-180"},{"key":"bibr28-1533317512461557","doi-asserted-by":"publisher","DOI":"10.1038\/ng0194-29"},{"key":"bibr29-1533317512461557","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.9.1416"},{"key":"bibr30-1533317512461557","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2011007500151"},{"key":"bibr31-1533317512461557","doi-asserted-by":"publisher","DOI":"10.1159\/000334607"},{"key":"bibr32-1533317512461557","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2000000500007"},{"key":"bibr33-1533317512461557","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2003000700013"},{"key":"bibr34-1533317512461557","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-011-6381-6"},{"key":"bibr35-1533317512461557","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1067"},{"key":"bibr36-1533317512461557","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.10.1566"},{"key":"bibr37-1533317512461557","doi-asserted-by":"publisher","DOI":"10.1159\/000063603"},{"key":"bibr38-1533317512461557","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(03)00333-1"},{"key":"bibr39-1533317512461557","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-200304000-00007"}],"container-title":["American Journal of Alzheimer's Disease &amp; Other Dementias\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1533317512461557","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1533317512461557","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1533317512461557","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:19:31Z","timestamp":1777367971000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1533317512461557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,4]]},"references-count":39,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1177\/1533317512461557"],"URL":"https:\/\/doi.org\/10.1177\/1533317512461557","relation":{},"ISSN":["1533-3175","1938-2731"],"issn-type":[{"value":"1533-3175","type":"print"},{"value":"1938-2731","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,4]]}}}