{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T20:27:27Z","timestamp":1780345647750,"version":"3.54.1"},"reference-count":27,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2012,12,21]],"date-time":"2012-12-21T00:00:00Z","timestamp":1356048000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Alzheimers Dis Other Demen"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p>Background: Restless legs syndrome (RLS) is a neurological disorder characterized by the urge to move the legs associated with peculiar unpleasant sensations during periods of rest and inactivity that are relieved by movement. A few studies analyzed RLS in neurodegenerative diseases such as Alzheimer's Disease (AD). The aim of our study was to assess the prevalence and the clinical characteristics of RLS in a cohort of AD patients. Methods: Three hundred and thirty-nine subjects with a diagnosis of AD were recruited. Cognitive, functional, and neuropsychiatric measures were collected at baseline and six-monthly for a 2-years follow-up Results: Fourteen subjects met the RLS criteria. RLS subjects were more frequently male (p:0,006) and younger than AD subject without RLS (p:0,029). MMSE, ADL and IADL were not significantly different. NPI total scores did not differ significantly, however, AD patients with RLS were found to be more apathetic (p:0,001) than AD subjects without RLS. Conclusion: RLS prevalence in our AD cohort was estimated to be about 4%. RLS appeared to be associated with neuropsychiatric symptoms such as apathy. RLS and apathy might share a common pathophysiological basis represented by a dysfunction of the central dopaminergic system<\/jats:p>","DOI":"10.1177\/1533317512470208","type":"journal-article","created":{"date-parts":[[2012,12,22]],"date-time":"2012-12-22T22:38:41Z","timestamp":1356215921000},"page":"165-170","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Restless Legs Syndrome in a Group of Patients With Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"28","author":[{"given":"Giuseppina","family":"Talarico","sequence":"first","affiliation":[{"name":"Memory Clinic, Department of Neurology and Psychiatry, University \u201cSapienza\u201d, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Canevelli","sequence":"additional","affiliation":[{"name":"Memory Clinic, Department of Neurology and Psychiatry, University \u201cSapienza\u201d, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Tosto","sequence":"additional","affiliation":[{"name":"Memory Clinic, Department of Neurology and Psychiatry, University \u201cSapienza\u201d, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Vanacore","sequence":"additional","affiliation":[{"name":"Epidemiology Center, National Institute of Health, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Letteri","sequence":"additional","affiliation":[{"name":"Memory Clinic, Department of Neurology and Psychiatry, University \u201cSapienza\u201d, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Prastaro","sequence":"additional","affiliation":[{"name":"Memory Clinic, Department of Neurology and Psychiatry, University \u201cSapienza\u201d, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Troili","sequence":"additional","affiliation":[{"name":"Memory Clinic, Department of Neurology and Psychiatry, University \u201cSapienza\u201d, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gasparini","sequence":"additional","affiliation":[{"name":"Memory Clinic, Department of Neurology and Psychiatry, University \u201cSapienza\u201d, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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