{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T13:09:35Z","timestamp":1793279375879,"version":"4.5.0"},"reference-count":34,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2013,5,17]],"date-time":"2013-05-17T00:00:00Z","timestamp":1368748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Alzheimers Dis Other Demen"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>\n                      Efficacy and safety of Cistanche tubulosa glycoside capsules (CTG capsule, Memoregain\n                      <jats:sup>\u00ae<\/jats:sup>\n                      ) for treating Alzheimer\u2019s disease (AD) were studied.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A total of 18 patients with AD administered with Memoregain\n                      <jats:sup>\u00ae<\/jats:sup>\n                      for 48 weeks were assessed for drug efficacy by Alzheimer\u2019s Disease Assessment Scale\u2013cognitive subscale (ADAS-cog), Mini-Mental State Examination (MMSE), Activities of Daily Living (ADLs), Blessed Behavioral Scale, and Clinical Global Impression (CGI) scales.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The MMSE score was 14.78 \u00b1 2.51 at baseline and 14.06 \u00b1 4.26 at study completion. While changes in ADAS-cog score before and after 48 weeks of treatment were statistically insignificant, the score improved, deteriorated, and remained unchanged in 10, 7, and 1 patients, respectively. The ADL and CGI scores showed no significant difference from baseline. All adverse reactions were mild.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      After Memoregain\n                      <jats:sup>\u00ae<\/jats:sup>\n                      treatment, patients with AD showed no obvious aggravation of cognitive function, independent living ability, and overall conditions but were stable throughout the study. Comparison with other long-term medications with acetylcholinesterase inhibitors suggests that Memoregain\n                      <jats:sup>\u00ae<\/jats:sup>\n                      has a potential to be a possible treatment option for mild to moderate AD. Large trials with bigger population are required to confirm.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1533317513488907","type":"journal-article","created":{"date-parts":[[2013,5,17]],"date-time":"2013-05-17T23:11:19Z","timestamp":1368832279000},"page":"363-370","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":50,"title":["An Open-Label, Nonplacebo-Controlled Study on\n                    <i>Cistanche tubulosa<\/i>\n                    Glycoside Capsules (Memoregain\n                    <sup>\u00ae<\/sup>\n                    ) for Treating Moderate Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"28","author":[{"given":"Qihao","family":"Guo","sequence":"first","affiliation":[{"name":"Institute of Neurology, Fudan University Huashan Affiliated Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Neurology, Fudan University Huashan Affiliated Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Jih","family":"Wang","sequence":"additional","affiliation":[{"name":"Research & Development Center, Sinphar Pharmaceutical Co., Ltd., Sinphar Group, Taiwan, Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Ming","family":"Huang","sequence":"additional","affiliation":[{"name":"Research & Development Center, Sinphar Pharmaceutical Co., Ltd., Sinphar Group, Taiwan, Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ta","family":"Lee","sequence":"additional","affiliation":[{"name":"Research & Development Center, Sinphar Pharmaceutical Co., Ltd., Sinphar Group, Taiwan, Republic of 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