{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:57:02Z","timestamp":1777381022279,"version":"3.51.4"},"reference-count":52,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Alzheimers Dis Other Demen"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p>\n                    Low level of vitamin B\n                    <jats:sub>12<\/jats:sub>\n                    and folic acid has been reported to play an important role in the pathogenesis of Alzheimer\u2019s disease (AD) and vascular dementia (VaD). Serum folic acid and vitamin B\n                    <jats:sub>12<\/jats:sub>\n                    were assayed in 80 AD and 50 VaD cases and in 120 healthy controls. The reduced folate carrier ( RFC1) gene, rs1051266, which encodes the RFC 1, protein was analyzed for polymorphism by polymerase chain reaction\u2013restriction fragment length polymorphism. It was observed that the patients having folic acid &lt;8.45 ng\/mL had 2.4 (95% confidence interval [CI]: 1.4-4.5) times higher odds of having AD and 2.1 (95% CI: 1.1-4.2) times higher odds of having VaD than patients having folic acid \u22658.45 ng\/mL. Serum vitamin B\n                    <jats:sub>12<\/jats:sub>\n                    level did not show any such statistically significant effect in altering the odds. No direct association was found between variant (G) allele or genotype of rs1051266 with AD and VaD cases. On serum folate level no association was observed with gene polymorphism.\n                  <\/jats:p>","DOI":"10.1177\/1533317513505131","type":"journal-article","created":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T06:33:18Z","timestamp":1392791598000},"page":"38-44","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Serum Folic Acid and\n                    <i>RFC A80G<\/i>\n                    Polymorphism in Alzheimer\u2019s Disease and Vascular Dementia"],"prefix":"10.1177","volume":"29","author":[{"given":"Nasim","family":"Mansoori","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manjari","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Department of Neurology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rizwan","family":"Alam","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalpana","family":"Luthra","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumit","family":"Sharma","sequence":"additional","affiliation":[{"name":"Link\u00f6ping University, Link\u00f6ping, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramakrishnan","family":"Lakshmy","sequence":"additional","affiliation":[{"name":"Department of Cardiac Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mani","family":"Kalaivani","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asok K.","family":"Mukhopadhyay","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,2,19]]},"reference":[{"key":"bibr1-1533317513505131","unstructured":"Edmonds ZV. 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