{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:14:04Z","timestamp":1787019244115,"version":"build-2736575974"},"reference-count":18,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2013,10,27]],"date-time":"2013-10-27T00:00:00Z","timestamp":1382832000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Alzheimers Dis Other Demen"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p>Alterations in DNA methylation have implicated as an epigenetic event in the pathogenesis of late-onset Alzheimer\u2019s disease (LOAD). The objective of this work was to evaluate global DNA methylation levels for long interspersed nuclear element 1 (LINE-1) repetitive sequences in Colombian patients with LOAD and controls. The LINE-1 DNA methylation levels in peripheral blood samples from 28 Colombian patients with LOAD and 30 healthy participants were assessed using a methylation-sensitive high-resolution melting (MS-HRM) quantitative assay. We did not find differences in LINE-1 methylation levels between patients with Alzheimer\u2019s disease (AD; median 76.2%, interquartile range [IQR]: 69.8-81.9) and control participants (median 79.8%, IQR: 73.2-83.8; P = .3). Additional stratified analyses did not show differences in LINE-1 methylation levels for male or female patients versus controls nor for apolipoprotein E4 carriers and noncarriers. This is the first report of LINE-1 methylation levels in patients with LOAD using the cost-effective MS-HRM technique, and this is the first global DNA methylation study in Latin American patients with AD.<\/jats:p>","DOI":"10.1177\/1533317513505132","type":"journal-article","created":{"date-parts":[[2013,10,28]],"date-time":"2013-10-28T20:40:36Z","timestamp":1382992836000},"page":"50-53","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":55,"title":["Global Long Interspersed Nuclear Element 1 DNA Methylation in a Colombian Sample of Patients With Late-Onset Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"29","author":[{"given":"Hern\u00e1n G.","family":"Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Laboratory of Neuropsychiatric Genetics, Biomedical Sciences Research Group, School of Medicine, Universidad Antonio Nari\u00f1o, Bogot\u00e1, Colombia"},{"name":"Neurosciences Research Group, School of Medicine and Institute of Genetics, Universidad Nacional de Colombia, Bogot\u00e1, Colombia"},{"name":"Biomedical Sciences Doctoral Program, School of Medicine, Universidad Nacional de Colombia, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda F.","family":"Mahecha","sequence":"additional","affiliation":[{"name":"Neurosciences Research Group, School of Medicine and Institute of Genetics, Universidad Nacional de Colombia, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Mej\u00eda","sequence":"additional","affiliation":[{"name":"Neurosciences Research Group, School of Medicine and Institute of Genetics, Universidad Nacional de Colombia, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humberto","family":"Arboleda","sequence":"additional","affiliation":[{"name":"Neurosciences Research Group, School of Medicine and Institute of Genetics, Universidad Nacional de Colombia, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego A.","family":"Forero","sequence":"additional","affiliation":[{"name":"Laboratory of Neuropsychiatric Genetics, Biomedical Sciences Research Group, School of Medicine, Universidad Antonio Nari\u00f1o, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,10,27]]},"reference":[{"key":"bibr1-1533317513505132","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-100303"},{"key":"bibr2-1533317513505132","doi-asserted-by":"publisher","DOI":"10.1159\/000165363"},{"key":"bibr3-1533317513505132","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2010.01.010"},{"key":"bibr4-1533317513505132","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(01)01829-8"},{"key":"bibr5-1533317513505132","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2012.55"},{"key":"bibr6-1533317513505132","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki987"},{"key":"bibr7-1533317513505132","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-4-565"},{"key":"bibr8-1533317513505132","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2011.01.017"},{"key":"bibr9-1533317513505132","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm013"},{"key":"bibr10-1533317513505132","doi-asserted-by":"publisher","DOI":"10.2144\/000114087"},{"key":"bibr11-1533317513505132","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2006.04.006"},{"key":"bibr12-1533317513505132","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-101518"},{"key":"bibr13-1533317513505132","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-006-0623-2"},{"key":"bibr14-1533317513505132","doi-asserted-by":"publisher","DOI":"10.4161\/epi.6.7.16500"},{"key":"bibr15-1533317513505132","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002698"},{"key":"bibr16-1533317513505132","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.191"},{"key":"bibr17-1533317513505132","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2012-111223"},{"key":"bibr18-1533317513505132","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2006.tb00439.x"}],"container-title":["American Journal of Alzheimer's Disease &amp; 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