{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:57:02Z","timestamp":1777381022690,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Alzheimers Dis Other Demen"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p>Hippocampal sclerosis (HS) and mesial temporal sclerosis (MTS) may occur with frontotemporal lobar degeneration (FTLD) and Alzheimer\u2019s disease (AD) as well as with normal aging. Prior studies suggest that HS\/MTS may be more closely associated with FTLD but have not directly compared the prevalence and clinical characteristics of HS\/MTS between neuropathologically confirmed early-onset (age \u2264 65) cohorts of FTLD and AD. We identified patients with early-onset FTLD (n = 136) and AD (n = 267) from National Alzheimer\u2019s Center Consortium databases and compared neuropathological and clinical data between these 2 groups. The FTLD group had a significantly higher prevalence of HS\/MTS than that of the AD group. However, HS\/MTS was associated with increasing age and memory impairment in the AD group but not in the FTLD group. These findings are consistent with the hypothesis that HS\/MTS in FTLD occurs as part of the primary pathological process, rather than as a secondary, nonspecific effect of aging on memory and hippocampal function.<\/jats:p>","DOI":"10.1177\/1533317513505134","type":"journal-article","created":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T22:45:19Z","timestamp":1380667519000},"page":"45-49","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Hippocampal and Mesial Temporal Sclerosis in Early-Onset Frontotemporal Lobar Degeneration Versus Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"29","author":[{"given":"Simantini J.","family":"Karve","sequence":"first","affiliation":[{"name":"Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmond","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA"},{"name":"V. A. Greater Los Angeles Healthcare System, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanida","family":"Tassniyom","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Khon Kaen University, Khon Kaen, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario F.","family":"Mendez","sequence":"additional","affiliation":[{"name":"Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA"},{"name":"V. A. Greater Los Angeles Healthcare System, Los Angeles, CA, USA"},{"name":"Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,10,1]]},"reference":[{"key":"bibr1-1533317513505134","doi-asserted-by":"publisher","DOI":"10.1007\/BF00293396"},{"key":"bibr2-1533317513505134","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-008-0057-3"},{"key":"bibr3-1533317513505134","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr053"},{"key":"bibr4-1533317513505134","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.11.1632"},{"key":"bibr5-1533317513505134","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e31820f8f50"},{"key":"bibr6-1533317513505134","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-010-0765-z"},{"key":"bibr7-1533317513505134","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.3323"},{"key":"bibr8-1533317513505134","doi-asserted-by":"publisher","DOI":"10.1097\/01.wad.0000213865.09806.92"},{"key":"bibr9-1533317513505134","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.11.2412-a"},{"key":"bibr10-1533317513505134","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.12.2.233"},{"key":"bibr11-1533317513505134","doi-asserted-by":"publisher","DOI":"10.1159\/000289231"},{"key":"bibr12-1533317513505134","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000133008.89613.82"},{"key":"bibr13-1533317513505134","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000129543.46734.C0"},{"key":"bibr14-1533317513505134","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-007-0262-1"},{"key":"bibr15-1533317513505134","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.66"},{"key":"bibr16-1533317513505134","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-012-1050-0"},{"key":"bibr17-1533317513505134","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-012-1048-7"},{"key":"bibr18-1533317513505134","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-013-1123-8"},{"key":"bibr19-1533317513505134","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.80.7_supplement.P05.099"},{"key":"bibr20-1533317513505134","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.80.7_supplement.P05.100"},{"key":"bibr21-1533317513505134","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21154"}],"container-title":["American Journal of Alzheimer's Disease &amp; Other Dementias\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1533317513505134","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1533317513505134","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1533317513505134","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:19:46Z","timestamp":1777367986000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1533317513505134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,1]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1177\/1533317513505134"],"URL":"https:\/\/doi.org\/10.1177\/1533317513505134","relation":{},"ISSN":["1533-3175","1938-2731"],"issn-type":[{"value":"1533-3175","type":"print"},{"value":"1938-2731","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,1]]}}}