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The purpose of this study was to test the feasibility and efficacy of many hours of intensive cognitive training with adults in the early stages of AD. Twenty-one adults with very mild or mild AD participated in cognitive training for 10 days over 2 weeks with 4 to 5 hours of training each day. Participants significantly improved in practiced computer-based tasks including those involving working memory, sustained attention, and switching attention. Outcome measures that improved included the Mini-Mental State Examination, letter fluency, and 3 of 5 Trail-Making Tests. Gains in outcome measures were maintained at 2- and 4-month follow-up. Adults in early-stage AD can participate in intensive cognitive training and make modest gains in both practiced and unpracticed cognitive tasks.<\/jats:p>","DOI":"10.1177\/1533317513506775","type":"journal-article","created":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T08:01:35Z","timestamp":1395734495000},"page":"150-158","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Feasibility and Efficacy of Intensive Cognitive Training in Early-Stage Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"29","author":[{"given":"Saddam F.","family":"Kanaan","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Sciences, Jordan University of Science and Technology, Al Ramtha, Irbid, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan M.","family":"McDowd","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Missouri-Kansas City, Kansas City, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Colgrove","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences, Jordan University of Science and Technology, Al Ramtha, Irbid, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffery M.","family":"Burns","sequence":"additional","affiliation":[{"name":"Department of Neurology and University of Kansas Alzheimer\u2019s Disease Center, University of Kansas Medical Center, Kansas City, KS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byron","family":"Gajewski","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Kansas Medical Center, Kansas City, KS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia S.","family":"Pohl","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, The Sage Colleges, Troy, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,3,25]]},"reference":[{"key":"bibr1-1533317513506775","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.8.1119"},{"key":"bibr2-1533317513506775","doi-asserted-by":"publisher","DOI":"10.1097\/JGP.0b013e3181c37ce9"},{"key":"bibr3-1533317513506775","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2006.00789.x"},{"issue":"4","key":"bibr4-1533317513506775","first-page":"CD003260","author":"Clare L","year":"2003","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr5-1533317513506775","doi-asserted-by":"publisher","DOI":"10.1017\/S104161020700631X"},{"key":"bibr6-1533317513506775","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.18.2271"},{"key":"bibr7-1533317513506775","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.23.2805"},{"key":"bibr8-1533317513506775","doi-asserted-by":"publisher","DOI":"10.1207\/s15324826an1004_3"},{"key":"bibr9-1533317513506775","doi-asserted-by":"publisher","DOI":"10.1080\/1360786031000101175"},{"key":"bibr10-1533317513506775","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-200101000-00001"},{"key":"bibr11-1533317513506775","doi-asserted-by":"publisher","DOI":"10.1159\/000096316"},{"key":"bibr12-1533317513506775","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2012.04.012"},{"key":"bibr13-1533317513506775","doi-asserted-by":"publisher","DOI":"10.1080\/09602011.2012.691044"},{"key":"bibr14-1533317513506775","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2005.12.003"},{"key":"bibr15-1533317513506775","volume-title":"Motor Control And Learning: A Behavioral Emphasis","author":"Schmidt R","year":"2005","edition":"4"},{"key":"bibr16-1533317513506775","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.17.2095"},{"key":"bibr17-1533317513506775","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.7.1621"},{"issue":"5","key":"bibr18-1533317513506775","first-page":"CR243","volume":"14","author":"Szaflarski JP","year":"2008","journal-title":"Med Sci Monit"},{"key":"bibr19-1533317513506775","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7007-2-20"},{"key":"bibr20-1533317513506775","doi-asserted-by":"publisher","DOI":"10.1080\/09602010244000390"},{"key":"bibr21-1533317513506775","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.58.3.397"},{"key":"bibr22-1533317513506775","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"bibr23-1533317513506775","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.11.2412-a"},{"key":"bibr24-1533317513506775","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.55.3.326"},{"key":"bibr25-1533317513506775","doi-asserted-by":"crossref","unstructured":"McDowd JM, Filion DL, Pohl PS, Richards LG, Stiers W. 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